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Ghassemi S, Martinez-Becerra FJ, Master AM, et al. Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Mol Ther Methods Clin Dev. 2020;18:595-606doi: 10.1016/j.omtm.2020.07.008.
Ghassemi, S., Martinez-Becerra, F. J., Master, A. M., Richman, S. A., Heo, D., Leferovich, J., Tu, Y., García-Cañaveras, J. C., Ayari, A., Lu, Y., Wang, A., Rabinowitz, J. D., Milone, M. C., June, C. H., & O'Connor, R. S. (2020). Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Molecular therapy. Methods & clinical development, 18595-606. https://doi.org/10.1016/j.omtm.2020.07.008
Ghassemi, Saba, et al. "Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design." Molecular therapy. Methods & clinical development vol. 18 (2020): 595-606. doi: https://doi.org/10.1016/j.omtm.2020.07.008
Ghassemi S, Martinez-Becerra FJ, Master AM, Richman SA, Heo D, Leferovich J, Tu Y, García-Cañaveras JC, Ayari A, Lu Y, Wang A, Rabinowitz JD, Milone MC, June CH, O'Connor RS. Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Mol Ther Methods Clin Dev. 2020 Jul 09;18:595-606. doi: 10.1016/j.omtm.2020.07.008. eCollection 2020 Sep 11. PMID: 32775494; PMCID: PMC7397397.
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Mol Ther Methods Clin Dev. 2020 Jul 09;18:595-606. doi: 10.1016/j.omtm.2020.07.008. eCollection 2020 Sep 11.

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design.

Molecular therapy. Methods & clinical development

Saba Ghassemi, Francisco J Martinez-Becerra, Alyssa M Master, Sarah A Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos García-Cañaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D Rabinowitz, Michael C Milone, Carl H June, Roddy S O'Connor

Affiliations

  1. Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
  3. Nucleus Biologics, LLC, San Diego, CA, USA.
  4. Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  5. Department of Biological Physics, University of Pennsylvania, Philadelphia, PA, USA.
  6. Department of Chemistry, Princeton University, Princeton, NJ, USA.
  7. Lewis-Singer Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

PMID: 32775494 PMCID: PMC7397397 DOI: 10.1016/j.omtm.2020.07.008

Abstract

Effective chimeric antigen receptor (CAR)-T cell therapy is dependent on optimal cell culture methods conducive to the activation and expansion of T cells

© 2020 The Author(s).

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