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Wang X, Wang H, Liu L, et al. Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors. iScience. 2020;23(7):101335doi: 10.1016/j.isci.2020.101335.
Wang, X., Wang, H., Liu, L., Li, S., Emery, G., & Chen, J. (2020). Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors. iScience, 23(7), 101335. https://doi.org/10.1016/j.isci.2020.101335
Wang, Xianping, et al. "Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors." iScience vol. 23,7 (2020): 101335. doi: https://doi.org/10.1016/j.isci.2020.101335
Wang X, Wang H, Liu L, Li S, Emery G, Chen J. Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors. iScience. 2020 Jul 24;23(7):101335. doi: 10.1016/j.isci.2020.101335. Epub 2020 Jul 01. PMID: 32682323; PMCID: PMC7366032.
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iScience. 2020 Jul 24;23(7):101335. doi: 10.1016/j.isci.2020.101335. Epub 2020 Jul 01.

Temporal Coordination of Collective Migration and Lumen Formation by Antagonism between Two Nuclear Receptors.

iScience

Xianping Wang, Heng Wang, Lin Liu, Sheng Li, Gregory Emery, Jiong Chen

Affiliations

  1. State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, 12 Xue-fu Road, Nanjing 210061, China.
  2. State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, 12 Xue-fu Road, Nanjing 210061, China. Electronic address: [email protected].
  3. Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Sciences and School of Life Sciences, South China Normal University, Guangzhou 510631, China.
  4. Institute for Research in Immunology and Cancer (IRIC) and Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, QC Canada.
  5. State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, 12 Xue-fu Road, Nanjing 210061, China. Electronic address: [email protected].

PMID: 32682323 PMCID: PMC7366032 DOI: 10.1016/j.isci.2020.101335

Abstract

During development, cells undergo multiple, distinct morphogenetic processes to form a tissue or organ, but how their temporal order and time interval are determined remain poorly understood. Here we show that the nuclear receptors E75 and DHR3 regulate the temporal order and time interval between the collective migration and lumen formation of a coherent group of cells named border cells during Drosophila oogenesis. We show that E75, in response to ecdysone signaling, antagonizes the activity of DHR3 during border cell migration, and DHR3 is necessary and sufficient for the subsequent lumen formation that is critical for micropyle morphogenesis. DHR3's lumen-inducing function is mainly mediated through βFtz-f1, another nuclear receptor and transcription factor. Furthermore, both DHR3 and βFtz-f1 are required for chitin secretion into the lumen, whereas DHR3 is sufficient for chitin secretion. Lastly, DHR3 and βFtz-f1 suppress JNK signaling in the border cells to downregulate cell adhesion during lumen formation.

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords: Biological Sciences; Developmental Biology; Organizational Aspects of Cell Biology

Conflict of interest statement

Declaration of Interests The authors declare no competing financial interests.

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