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Chen X, Zhou X, Xia X, et al. Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions. J Aerosol Sci. 2020;151:105626doi: 10.1016/j.jaerosci.2020.105626.
Chen, X., Zhou, X., Xia, X., Xie, X., Lu, P., & Feng, Y. (2021). Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions. Journal of aerosol science, 151105626. https://doi.org/10.1016/j.jaerosci.2020.105626
Chen, Xiaole, et al. "Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions." Journal of aerosol science vol. 151 (2021): 105626. doi: https://doi.org/10.1016/j.jaerosci.2020.105626
Chen X, Zhou X, Xia X, Xie X, Lu P, Feng Y. Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions. J Aerosol Sci. 2021 Jan;151:105626. doi: 10.1016/j.jaerosci.2020.105626. Epub 2020 Jul 24. PMID: 32836373; PMCID: PMC7378524.
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J Aerosol Sci. 2021 Jan;151:105626. doi: 10.1016/j.jaerosci.2020.105626. Epub 2020 Jul 24.

Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions.

Journal of aerosol science

Xiaole Chen, Xianguang Zhou, Xueying Xia, Xiaojian Xie, Ping Lu, Yu Feng

Affiliations

  1. School of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing, Jiangsu, 210046, China.
  2. Zhongda Hospital, Southeast University, Nanjing, Jiangsu, 210096, China.
  3. School of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.

PMID: 32836373 PMCID: PMC7378524 DOI: 10.1016/j.jaerosci.2020.105626

Abstract

Accurate predictions of the droplet transport, evolution, and deposition in human airways are critical for the quantitative analysis of the health risks due to the exposure to the airborne pollutant or virus transmission. The droplet/particle-vapor interaction, i.e., the evaporation or condensation of the multi-component droplet/particle, is one of the key mechanisms that need to be precisely modeled. Using a validated computational model, the transport, evaporation, hygroscopic growth, and deposition of multi-component droplets were simulated in a simplified airway geometry. A mucus-tissue layer is explicitly modeled in the airway geometry to describe mucus evaporation and heat transfer. Pulmonary flow and aerosol dynamics patterns associated with different inhalation flow rates are visualized and compared. Investigated variables include temperature distributions, relative humidity (RH) distributions, deposition efficiencies, droplet/particle distributions, and droplet growth ratio distributions. Numerical results indicate that the droplet/particle-vapor interaction and the heat and mass transfer of the mucus-tissue layer must be considered in the computational lung aerosol dynamics study, since they can significantly influence the precise predictions of the aerosol transport and deposition. Furthermore, the modeling framework in this study is ready to be expanded to predict transport dynamics of cough/sneeze droplets starting from their generation and transmission in the indoor environment to the deposition in the human respiratory system.

© 2020 Published by Elsevier Ltd.

Keywords: Airway; Deposition; Droplet; Hygroscopicity; Multi-component

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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