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J Clin Med. 2020 Aug 02;9(8). doi: 10.3390/jcm9082481.

Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy.

Journal of clinical medicine

Kirk Jensen, Shilpa Thakur, Aneeta Patel, Maria Cecilia Mendonca-Torres, John Costello, Cristiane Jeyce Gomes-Lima, Mary Walter, Leonard Wartofsky, Kenneth Dale Burman, Athanasios Bikas, Dorina Ylli, Vasyl V Vasko, Joanna Klubo-Gwiezdzinska

Affiliations

  1. Department of Pediatrics, Endocrine Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
  2. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
  3. MedStar Health Research Institute, MedStar Washington Hospital Center, Washington, DC 20010, USA.
  4. Endocrinology Division, University of Medicine, Tirana 1005, Albania.

PMID: 32748840 PMCID: PMC7464493 DOI: 10.3390/jcm9082481

Abstract

The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the

Keywords: BRAFV600E; COLD-PCR; digital PCR; liquid biopsy; papillary thyroid cancer

Conflict of interest statement

The authors declare no conflict of interest.

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