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Kodesh A, Goldberg Y, Rotstein A, et al. Risk of dementia and death in very-late-onset schizophrenia-like psychosis: A national cohort study. Schizophr Res. 2020;223:220-226doi: 10.1016/j.schres.2020.07.020.
Kodesh, A., Goldberg, Y., Rotstein, A., Weinstein, G., Reichenberg, A., Sandin, S., & Levine, S. Z. (2020). Risk of dementia and death in very-late-onset schizophrenia-like psychosis: A national cohort study. Schizophrenia research, 223220-226. https://doi.org/10.1016/j.schres.2020.07.020
Kodesh, Arad, et al. "Risk of dementia and death in very-late-onset schizophrenia-like psychosis: A national cohort study." Schizophrenia research vol. 223 (2020): 220-226. doi: https://doi.org/10.1016/j.schres.2020.07.020
Kodesh A, Goldberg Y, Rotstein A, Weinstein G, Reichenberg A, Sandin S, Levine SZ. Risk of dementia and death in very-late-onset schizophrenia-like psychosis: A national cohort study. Schizophr Res. 2020 Sep;223:220-226. doi: 10.1016/j.schres.2020.07.020. Epub 2020 Aug 14. PMID: 32807646.
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Schizophr Res. 2020 Sep;223:220-226. doi: 10.1016/j.schres.2020.07.020. Epub 2020 Aug 14.

Risk of dementia and death in very-late-onset schizophrenia-like psychosis: A national cohort study.

Schizophrenia research

Arad Kodesh, Yair Goldberg, Anat Rotstein, Galit Weinstein, Abraham Reichenberg, Sven Sandin, Stephen Z Levine

Affiliations

  1. Department of Community Mental Health, University of Haifa, Haifa, Israel; Meuhedet Health Services, Mental Health, Tel Aviv, Israel.
  2. Faculty of Industrial Engineering and Management, Israel Institute of Technology, Haifa,Israel.
  3. Department of Community Mental Health, University of Haifa, Haifa, Israel.
  4. School of Public Health, University of Haifa, Haifa, Israel.
  5. The Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
  6. The Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  7. Department of Community Mental Health, University of Haifa, Haifa, Israel. Electronic address: [email protected].

PMID: 32807646 DOI: 10.1016/j.schres.2020.07.020

Abstract

Knowledge is limited regarding the risks of death and dementia in very-late onset schizophrenia-like psychosis (VLOS). This study aims to scrutinize the associations between VLOS with the risks of death and dementia. Based on a prospective Israeli cohort study with national coverage, 94,120 persons without dementia or schizophrenia diagnoses aged 60 to 90 in 2012 were followed-up for the risks of dementia or death from 2013 to 2017. VLOS was classified as present from the age of the first ICD-9 diagnosis during follow-up, otherwise as absent. Hazard ratios (HR) with confidence intervals (95% CI) were computed with survival models to quantify the associations between VLOS and the risks of death and dementia, without and with adjustment for confounding. Nine sensitivity analyses were computed to examine the robustness of the results. The group with VLOS, compared to the group without, had higher death (n = 61, 18.5% vs. n = 7028, 7.5%, respectively) and dementia (n = 64, 19.5% vs. n = 5962, 6.4%, respectively) rates. In the primary analysis, the group with VLOS compared to the group without had increased risks of death (unadjusted HR = 3.10, 95% CI = 2.36, 4.06, P < .001; adjusted HR = 2.89, 95% CI = 2.15, 3.89; P < .001) and dementia (unadjusted HR = 3.81, 95% CI = 2.90, 4.99, P < .001; adjusted HR = 2.67, 95% CI = 1.82, 3.91; P < .001). The results remained statistically significant (P < .05) in all sensitivity analyses, including among persons without antipsychotic medication. The results may support notions of increased dementia risk and accelerated aging in VLOS, or that VLOS is a prodromal state of dementia.

Copyright © 2020 Elsevier B.V. All rights reserved.

Keywords: Accelerated aging; Dementia; Epidemiology; Mortality; Schizophrenia

Conflict of interest statement

Declaration of competing interest The authors have no conflicts of interest to report.

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