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Schroeder JC, Puntigam L, Hofmann L, et al. Circulating Exosomes Inhibit B Cell Proliferation and Activity. Cancers (Basel). 2020;12(8)doi: 10.3390/cancers12082110.
Schroeder, J. C., Puntigam, L., Hofmann, L., Jeske, S. S., Beccard, I. J., Doescher, J., Laban, S., Hoffmann, T. K., Brunner, C., Theodoraki, M. N., & Schuler, P. J. (2020). Circulating Exosomes Inhibit B Cell Proliferation and Activity. Cancers, 12(8), . https://doi.org/10.3390/cancers12082110
Schroeder, Jan C, et al. "Circulating Exosomes Inhibit B Cell Proliferation and Activity." Cancers vol. 12,8 (2020). doi: https://doi.org/10.3390/cancers12082110
Schroeder JC, Puntigam L, Hofmann L, Jeske SS, Beccard IJ, Doescher J, Laban S, Hoffmann TK, Brunner C, Theodoraki MN, Schuler PJ. Circulating Exosomes Inhibit B Cell Proliferation and Activity. Cancers (Basel). 2020 Jul 29;12(8). doi: 10.3390/cancers12082110. PMID: 32751214; PMCID: PMC7464446.
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Cancers (Basel). 2020 Jul 29;12(8). doi: 10.3390/cancers12082110.

Circulating Exosomes Inhibit B Cell Proliferation and Activity.

Cancers

Jan C Schroeder, Lisa Puntigam, Linda Hofmann, Sandra S Jeske, Inga J Beccard, Johannes Doescher, Simon Laban, Thomas K Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki, Patrick J Schuler

Affiliations

  1. Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University, 89075 Ulm, Germany.

PMID: 32751214 PMCID: PMC7464446 DOI: 10.3390/cancers12082110

Abstract

(1) Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by a distinctive suppression of the anti-tumor immunity, both locally in the tumor microenvironment (TME) and the periphery. Tumor-derived exosomes mediate this immune suppression by directly suppressing T effector function and by inducing differentiation of regulatory T cells. However, little is known about the effects of exosomes on B cells. (2) Methods: Peripheral B cells from healthy donors and HNSCC patients were isolated and checkpoint receptor expression was analyzed by flow cytometry. Circulating exosomes were isolated from the plasma of HNSCC patients (

Keywords: B cells; Bruton’s tyrosine kinase; Head and Neck Cancer; exosomes

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