Display options
Cite
Luo D, Li C, Wu L, et al. [Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer]. Zhongguo Fei Ai Za Zhi. 2020;23(11):999-1006doi: 10.3779/j.issn.1009-3419.2020.101.24.
Luo, D., Li, C., Wu, L., & Chen, Q. (2020). [Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer]. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 23(11), 999-1006. https://doi.org/10.3779/j.issn.1009-3419.2020.101.24
Luo, Dan, et al. "[Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer]." Zhongguo fei ai za zhi = Chinese journal of lung cancer vol. 23,11 (2020): 999-1006. doi: https://doi.org/10.3779/j.issn.1009-3419.2020.101.24
Luo D, Li C, Wu L, Chen Q. [Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer]. Zhongguo Fei Ai Za Zhi. 2020 Nov 20;23(11):999-1006. doi: 10.3779/j.issn.1009-3419.2020.101.24. Epub 2020 Aug 05. Chinese. PMID: 32752584; PMCID: PMC7679221.
Copy Download .nbib Format: NLM
Share it on

Zhongguo Fei Ai Za Zhi. 2020 Nov 20;23(11):999-1006. doi: 10.3779/j.issn.1009-3419.2020.101.24. Epub 2020 Aug 05.

[Advances of Exosomes Extraction and Its Mechanism in Early Diagnosis of Lung Cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer

[Article in Chinese]
Dan Luo, Chunlei Li, Lun Wu, Qinhua Chen

Affiliations

  1. Department of Medical Experimental Center, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan 442008, China.
  2. Hubei University of Medicine, College of Pharmacy, Shiyan 442000, China.
  3. Shenzhen Baoan Authentic Traditional Chinese Medicine Therapy Hospital, Shenzhen 518102, China.

PMID: 32752584 PMCID: PMC7679221 DOI: 10.3779/j.issn.1009-3419.2020.101.24

Abstract

Lung cancer is a malignant tumor with high incidence and mortality in the world, which seriously threatens people's safety and health. Early diagnosis of lung cancer is the key part in the process of prevention and treatment of lung cancer. It can improve the survival of patients with lung cancer. Exosomes are closely related to the invasion and metastasis process of tumor, it plays an important role in the development of lung cancer. Biomarkers based on exosomes have become a powerful diagnostic tool of lung cancer. Exosomes are lipid bilayer vesicles with uniform size and diameter of 30 nm-200 nm secreted by cells. Exosomes contain different types of nucleic acids and proteins. These nucleic acids and proteins are derived from their parent cells (including parent cancer cells), which have a wide range of physiological functions, including immune regulation, intercellular communication and other physiological activities. Biomacromolecules in exosomes, such as single-stranded RNA, long noncoding RNA, microRNA, protein and lipids, which can provide valuable genetic information for early clinical diagnosis of lung cancer. This review described the origin, structural characteristics, extraction methods, biological characteristics of exosomes and the relationships of exosomes in the early diagnosis of lung cancer.
.

Keywords: Early diagnosis; Exosomes; Lung neoplasms

References

  1. Biomicrofluidics. 2016 May 05;10(3):032902 - PubMed
  2. Methods. 2015 Oct 1;87:31-45 - PubMed
  3. Oncotarget. 2017 Feb 21;8(8):13048-13058 - PubMed
  4. J Lab Autom. 2016 Aug;21(4):599-608 - PubMed
  5. Biomed Pharmacother. 2019 Jun;114:108791 - PubMed
  6. Sci Rep. 2014 Aug 29;4:6232 - PubMed
  7. NPJ Precis Oncol. 2017 Oct 17;1(1):36 - PubMed
  8. Methods Mol Biol. 2015;1218:465-81 - PubMed
  9. Cancer Cell. 2017 Feb 13;31(2):172-179 - PubMed
  10. J Proteomics. 2016 Feb 5;133:161-169 - PubMed
  11. J Clin Med. 2019 Mar 18;8(3): - PubMed
  12. J Thorac Oncol. 2013 Sep;8(9):1156-62 - PubMed
  13. Biochem Biophys Res Commun. 2015 May 22;461(1):76-9 - PubMed
  14. Eur J Radiol. 2003 Jan;45(1):8-17 - PubMed
  15. N Engl J Med. 2017 Aug 31;377(9):849-861 - PubMed
  16. J Cell Mol Med. 2006 Apr-Jun;10(2):376-88 - PubMed
  17. Environ Health Prev Med. 2014 Nov;19(6):452-8 - PubMed
  18. Oncotarget. 2017 Jan 24;8(4):6513-6525 - PubMed
  19. Science. 2008 Feb 29;319(5867):1244-7 - PubMed
  20. Methods. 2015 Oct 1;87:46-58 - PubMed
  21. Scand J Immunol. 2015 Jan;81(1):2-10 - PubMed
  22. J Extracell Vesicles. 2014 Sep 08;3: - PubMed
  23. Cell Mol Life Sci. 2018 Oct;75(19):3539-3551 - PubMed
  24. Expert Rev Mol Diagn. 2019 May;19(5):419-427 - PubMed
  25. Ann Oncol. 2017 Mar 1;28(3):468-477 - PubMed
  26. Nature. 2015 Nov 19;527(7578):329-35 - PubMed
  27. Methods Mol Biol. 2008;484:97-109 - PubMed
  28. Eur J Neurosci. 2016 Aug;44(4):2114-9 - PubMed
  29. Zhongguo Fei Ai Za Zhi. 2018 Aug 20;21(8):620-627 - PubMed
  30. Science. 2020 Feb 7;367(6478): - PubMed
  31. Anal Bioanal Chem. 2018 Jun;410(16):3805-3814 - PubMed
  32. J Extracell Vesicles. 2019 Sep 18;8(1):1663666 - PubMed
  33. Mol Oncol. 2016 Dec;10(10):1595-1602 - PubMed
  34. Ann Transl Med. 2019 Feb;7(3):40 - PubMed
  35. J Extracell Vesicles. 2012 Apr 16;1: - PubMed
  36. ACS Nano. 2017 Nov 28;11(11):10712-10723 - PubMed
  37. J Mol Med (Berl). 2013 Apr;91(4):431-7 - PubMed
  38. Clin Biochem. 2014 Sep;47(13-14):1286-92 - PubMed
  39. Cancer Sci. 2019 Jan;110(1):433-442 - PubMed
  40. Methods. 2015 Oct 1;87:26-30 - PubMed
  41. Cancers (Basel). 2017 Jan 12;9(1): - PubMed
  42. PLoS One. 2015 Dec 21;10(12):e0145686 - PubMed
  43. Lung Cancer. 2014 Oct;86(1):78-84 - PubMed
  44. Am J Respir Crit Care Med. 2017 Dec 15;196(12):1510-1518 - PubMed
  45. J Immunol Methods. 2014 Sep;411:55-65 - PubMed
  46. Methods Mol Biol. 2015;1295:179-209 - PubMed
  47. Phytomedicine. 2019 May;58:152888 - PubMed
  48. Thorac Cancer. 2019 Apr;10(4):957-965 - PubMed
  49. Genomics Proteomics Bioinformatics. 2015 Feb;13(1):17-24 - PubMed
  50. Biofactors. 2019 May;45(3):393-400 - PubMed
  51. Nat Rev Clin Oncol. 2017 Sep;14(9):531-548 - PubMed
  52. Expert Rev Anticancer Ther. 2019 Jul;19(7):547-559 - PubMed
  53. Am J Cancer Res. 2019 Feb 01;9(2):406-414 - PubMed
  54. Chem Rev. 2018 Feb 28;118(4):1917-1950 - PubMed
  55. Tumour Biol. 2016 Aug;37(8):10703-14 - PubMed
  56. Annu Rev Cell Dev Biol. 2014;30:255-89 - PubMed
  57. Theranostics. 2017 Jan 26;7(3):789-804 - PubMed
  58. Clin Chem. 2015 Jan;61(1):112-23 - PubMed
  59. J Hematol Oncol. 2016 Apr 18;9:42 - PubMed
  60. Onco Targets Ther. 2019 Mar 12;12:1947-1956 - PubMed
  61. J Extracell Vesicles. 2015 Jul 17;4:27031 - PubMed
  62. J Thorac Oncol. 2016 Oct;11(10):1701-10 - PubMed
  63. Methods Mol Biol. 2011;728:235-46 - PubMed
  64. Oncotarget. 2016 Aug 23;7(34):54852-54866 - PubMed
  65. Molecules. 2014 Jan 27;19(2):1568-75 - PubMed
  66. Cancer Res. 2013 Nov 1;73(21):6384-8 - PubMed
  67. Lung Cancer Manag. 2016 Jun;5(2):91-104 - PubMed
  68. J Histochem Cytochem. 2015 Mar;63(3):181-9 - PubMed
  69. PLoS One. 2017 Jan 23;12(1):e0170628 - PubMed
  70. J Vet Med Sci. 2012 Nov;74(11):1523-5 - PubMed

MeSH terms

Publication Types