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van der Voort PHJ, Moser J, Zandstra DF, et al. Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon. 2020;6(8):e04696doi: 10.1016/j.heliyon.2020.e04696.
van der Voort, P. H. J., Moser, J., Zandstra, D. F., Muller Kobold, A. C., Knoester, M., Calkhoven, C. F., Hamming, I., & van Meurs, M. (2020). Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon, 6(8), e04696. https://doi.org/10.1016/j.heliyon.2020.e04696
van der Voort, Peter H J, et al. "Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue." Heliyon vol. 6,8 (2020): e04696. doi: https://doi.org/10.1016/j.heliyon.2020.e04696
van der Voort PHJ, Moser J, Zandstra DF, Muller Kobold AC, Knoester M, Calkhoven CF, Hamming I, van Meurs M. Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon. 2020 Aug;6(8):e04696. doi: 10.1016/j.heliyon.2020.e04696. Epub 2020 Aug 20. PMID: 32844126; PMCID: PMC7439829.
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Heliyon. 2020 Aug;6(8):e04696. doi: 10.1016/j.heliyon.2020.e04696. Epub 2020 Aug 20.

Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue.

Heliyon

Peter H J van der Voort, Jill Moser, Durk F Zandstra, Anneke C Muller Kobold, Marjolein Knoester, Cornelis F Calkhoven, Inge Hamming, Matijs van Meurs

Affiliations

  1. Department of Critical Care, University of Groningen, University Medical Center Groningen, 9700, RB, Groningen, the Netherlands.
  2. Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9700, RB, Groningen, the Netherlands.
  3. Department of Clinical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, 9700, RB, Groningen, the Netherlands.
  4. European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, 9700, AD, Groningen, the Netherlands.

PMID: 32844126 PMCID: PMC7439829 DOI: 10.1016/j.heliyon.2020.e04696

Abstract

Obesity is a risk factor for SARS-CoV-2 infected patients to develop respiratory failure. Leptin produced in visceral fat might play a role in the deterioration to mechanical ventilation. A cross sectional study was performed. The mean BMI was 31 kg/m

© 2020 The Author(s).

Keywords: ACE2; ARDS; COVID-19; Critical care; Fat; Intensive care medicine; Leptin; Microbiology; Respiratory system; SARS-CoV-2; Virology

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