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Cancers (Basel). 2020 Aug 24;12(9). doi: 10.3390/cancers12092397.

Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers.

Cancers

Eylem Kulkoyluoglu Cotul, Qianying Zuo, Ashlie Santaliz-Casiano, Ozan Berk Imir, Ayca Nazli Mogol, Elif Tunc, Kevin Duong, Jenna Kathryn Lee, Rithva Ramesh, Elijah Odukoya, Mrinali P Kesavadas, Monika Ziogaite, Brandi Patrice Smith, Chengjian Mao, David J Shapiro, Ben Ho Park, Benita S Katzenellenbogen, Drew Daly, Evelyn Aranda, John D O'Neill, Christopher Walker, Yosef Landesman, Zeynep Madak-Erdogan

Affiliations

  1. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  2. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  3. Department of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  4. Department of Human Development and Family Studies, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  5. Department of Interdisciplinary Health Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  6. Department of Informatics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  7. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  8. Cancer Center at Illinois, Urbana, IL 61801, USA.
  9. Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  10. Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  11. Xylyx Bio, Inc., Brooklyn, NY 11226, USA.
  12. Karyopharm Therapeutics, Newton, MA 02459, USA.
  13. Beckman Institute for Advanced Science and Technology, Urbana, IL 61801, USA.
  14. Carl R. Woese Institute of Genomic Biology, Urbana, IL 61801, USA.

PMID: 32847042 PMCID: PMC7563274 DOI: 10.3390/cancers12092397

Abstract

The majority of breast cancer specific deaths in women with estrogen receptor positive (ER

Keywords: ESR1 mutant models; breast cancer; combination therapies; glutamine; metabolic rewiring; selinexor; tamoxifen

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