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Gilca R, Carazo S, Amini R, et al. Relative Severity of Common Human Coronaviruses and Influenza in Patients Hospitalized With Acute Respiratory Infection: Results From 8-Year Hospital-Based Surveillance in Quebec, Canada. J Infect Dis. 2021;223(6):1078-1087doi: 10.1093/infdis/jiaa477.
Gilca, R., Carazo, S., Amini, R., Charest, H., & De Serres, G. (2021). Relative Severity of Common Human Coronaviruses and Influenza in Patients Hospitalized With Acute Respiratory Infection: Results From 8-Year Hospital-Based Surveillance in Quebec, Canada. The Journal of infectious diseases, 223(6), 1078-1087. https://doi.org/10.1093/infdis/jiaa477
Gilca, Rodica, et al. "Relative Severity of Common Human Coronaviruses and Influenza in Patients Hospitalized With Acute Respiratory Infection: Results From 8-Year Hospital-Based Surveillance in Quebec, Canada." The Journal of infectious diseases vol. 223,6 (2021): 1078-1087. doi: https://doi.org/10.1093/infdis/jiaa477
Gilca R, Carazo S, Amini R, Charest H, De Serres G. Relative Severity of Common Human Coronaviruses and Influenza in Patients Hospitalized With Acute Respiratory Infection: Results From 8-Year Hospital-Based Surveillance in Quebec, Canada. J Infect Dis. 2021 Mar 29;223(6):1078-1087. doi: 10.1093/infdis/jiaa477. PMID: 32761209; PMCID: PMC7454730.
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J Infect Dis. 2021 Mar 29;223(6):1078-1087. doi: 10.1093/infdis/jiaa477.

Relative Severity of Common Human Coronaviruses and Influenza in Patients Hospitalized With Acute Respiratory Infection: Results From 8-Year Hospital-Based Surveillance in Quebec, Canada.

The Journal of infectious diseases

Rodica Gilca, Sara Carazo, Rachid Amini, Hugues Charest, Gaston De Serres

Affiliations

  1. Direction des risques biologiques et de la santé au travail, Institut national de santé publique du Québec, Quebec City, Quebec, Canada.
  2. Centre de Recherche du CHU de Québec-Université Laval, Quebec City, Quebec, Canada.
  3. Laboratoire de Santé Publique du Québec, Institut national de santé publique du Québec, Montreal, Quebec, Canada.

PMID: 32761209 PMCID: PMC7454730 DOI: 10.1093/infdis/jiaa477

Abstract

BACKGROUND: Few data exist concerning the role of common human coronaviruses (HCoVs) in patients hospitalized for acute respiratory infection (ARI) and the severity of these infections compared with influenza.

METHODS: Prospective data on the viral etiology of ARI hospitalizations during the peaks of 8 influenza seasons (from 2011-2012 to 2018-2019) in Quebec, Canada, were used to compare patients with HCoV and those with influenza infections; generalized estimation equations models were used for multivariate analyses.

RESULTS: We identified 340 HCoV infections, which affected 11.6% of children (n = 136) and 5.2% of adults (n = 204) hospitalized with ARI. The majority of children (75%) with HCoV infections were also coinfected with other respiratory viruses, compared with 24% of the adults (P < .001). No deaths were recorded in children; 5.8% of adults with HCoV monoinfection died, compared with 4.2% of those with influenza monoinfection (P = .23). The risk of pneumonia was nonsignificantly lower in children with HCoV than in those with influenza, but these risks were similarly high in adults. Markers of severity (length of stay, intensive care unit admissions, and case-fatality ratio) were comparable between these infections in multivariate analyses, in both children and adults.

CONCLUSIONS: In children and adults hospitalized with ARI, HCoV infections were less frequent than influenza infections, but were as severe as influenza monoinfections.

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Keywords: adults; case-fatality ratio; children; coinfections; common coronaviruses; influenza; respiratory hospitalization; severity

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