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Kiseleva AA, Nikonova AS, Golemis EA. Patterns of Ciliation and Ciliary Signaling in Cancer. Rev Physiol Biochem Pharmacol. 2020;doi: 10.1007/112_2020_36.
Kiseleva, A. A., Nikonova, A. S., & Golemis, E. A. (2020). Patterns of Ciliation and Ciliary Signaling in Cancer. Reviews of physiology, biochemistry and pharmacology, . https://doi.org/10.1007/112_2020_36
Kiseleva, Anna A, et al. "Patterns of Ciliation and Ciliary Signaling in Cancer." Reviews of physiology, biochemistry and pharmacology vol. (2020). doi: https://doi.org/10.1007/112_2020_36
Kiseleva AA, Nikonova AS, Golemis EA. Patterns of Ciliation and Ciliary Signaling in Cancer. Rev Physiol Biochem Pharmacol. 2020 Aug 07; doi: 10.1007/112_2020_36. Epub 2020 Aug 07. PMID: 32761455.
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Rev Physiol Biochem Pharmacol. 2020 Aug 07; doi: 10.1007/112_2020_36. Epub 2020 Aug 07.

Patterns of Ciliation and Ciliary Signaling in Cancer.

Reviews of physiology, biochemistry and pharmacology

Anna A Kiseleva, Anna S Nikonova, Erica A Golemis

Affiliations

  1. Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA.
  2. Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA. [email protected].

PMID: 32761455 DOI: 10.1007/112_2020_36

Abstract

Among the factors that have been strongly implicated in regulating cancerous transformation, the primary monocilium (cilium) has gained increasing attention. The cilium is a small organelle extending from the plasma membrane, which provides a localized hub for concentration of transmembrane receptors. These receptors transmit signals from soluble factors (including Sonic hedgehog (SHH), platelet-derived growth factor (PDGF-AA), WNT, TGFβ, NOTCH, and others) that regulate cell growth, as well as mechanosensory cues provided by flow or extracellular matrix. Ciliation is regulated by cell cycle, with most cells that are in G0 (quiescent) or early G1 ciliation and cilia typically absent in G2/M cells. Notably, while most cells organized in solid tissues are ciliated, cancerous transformation induces significant changes in ciliation. Most cancer cells lose cilia; medulloblastomas and basal cell carcinomas, dependent on an active SHH pathway, rely on ciliary maintenance. Changes in cancer cell ciliation are driven by core oncogenic pathways (EGFR, KRAS, AURKA, PI3K), and importantly ciliation status regulates functionality of those pathways. Ciliation is both influenced by targeted cancer therapies and linked to therapeutic resistance; recent studies suggest ciliation may also influence cancer cell metabolism and stem cell identity. We review recent studies defining the relationship between cilia and cancer.

Keywords: Aurora-A; Cilium; Extracellular vesicle; NEDD9; Stroma; Targeted therapy

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