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Aldabain L, Camire L, Weisman DS. A rare case of spontaneous tumor lysis syndrome in multiple myeloma. J Community Hosp Intern Med Perspect. 2020;10(4):365-368doi: 10.1080/20009666.2020.1781748.
Aldabain, L., Camire, L., & Weisman, D. S. (2020). A rare case of spontaneous tumor lysis syndrome in multiple myeloma. Journal of community hospital internal medicine perspectives, 10(4), 365-368. https://doi.org/10.1080/20009666.2020.1781748
Aldabain, Louay, et al. "A rare case of spontaneous tumor lysis syndrome in multiple myeloma." Journal of community hospital internal medicine perspectives vol. 10,4 (2020): 365-368. doi: https://doi.org/10.1080/20009666.2020.1781748
Aldabain L, Camire L, Weisman DS. A rare case of spontaneous tumor lysis syndrome in multiple myeloma. J Community Hosp Intern Med Perspect. 2020 Aug 02;10(4):365-368. doi: 10.1080/20009666.2020.1781748. PMID: 32850100; PMCID: PMC7427459.
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J Community Hosp Intern Med Perspect. 2020 Aug 02;10(4):365-368. doi: 10.1080/20009666.2020.1781748.

A rare case of spontaneous tumor lysis syndrome in multiple myeloma.

Journal of community hospital internal medicine perspectives

Louay Aldabain, Lyn Camire, David S Weisman

Affiliations

  1. Department of Medicine, MedStar Health Internal Medicine Residency Program, Baltimore, MD, USA.
  2. School of Medicine, Georgetown University, Washington, DC, USA.

PMID: 32850100 PMCID: PMC7427459 DOI: 10.1080/20009666.2020.1781748

Abstract

Spontaneous tumor lysis syndrome is an uncommon oncologic emergency. It occurs when a massive number of malignant cells release their contents to the blood stream without previous cancer treatment. TLS carries a mortality rate exceeding 15%. Because of the high mortality rate, the key to the management of TLS continues to be early recognition of high-risk patients and using prophylactic measures to prevent its occurrence. However, it remains difficult to completely eradicate TLS, as a small proportion of patients with aggressive tumors develop spontaneous TLS prior to receiving any therapy. We present a case of 58-year-old male with recently diagnosed multiple myeloma. He was found to have hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia, elevated LDH levels, and acute renal failure, fulfilling the criteria of clinical TLS. He was treated with rasburicase, continuous renal replacement therapy, and dexamethasone.

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center.

Keywords: Spontaneous tumor lysis syndrome; hyperkalemia; hyperphosphatemia; hyperuricemia; hypocalcemia; multiple myeloma

Conflict of interest statement

No potential conflict of interest was reported by the authors.

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