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Chen R, Jäättelä M, Liu B. Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors. Cancers (Basel). 2020;12(9)doi: 10.3390/cancers12092437.
Chen, R., Jäättelä, M., & Liu, B. (2020). Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors. Cancers, 12(9), . https://doi.org/10.3390/cancers12092437
Chen, Ran, et al. "Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors." Cancers vol. 12,9 (2020). doi: https://doi.org/10.3390/cancers12092437
Chen R, Jäättelä M, Liu B. Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors. Cancers (Basel). 2020 Aug 27;12(9). doi: 10.3390/cancers12092437. PMID: 32867178; PMCID: PMC7565471.
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Cancers (Basel). 2020 Aug 27;12(9). doi: 10.3390/cancers12092437.

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors.

Cancers

Ran Chen, Marja Jäättelä, Bin Liu

Affiliations

  1. Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
  2. Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.

PMID: 32867178 PMCID: PMC7565471 DOI: 10.3390/cancers12092437

Abstract

Cancer cells generate large quantities of cytoplasmic protons as byproducts of aberrantly activated aerobic glycolysis and lactate fermentation. To avoid potentially detrimental acidification of the intracellular milieu, cancer cells activate multiple acid-removal pathways that promote cytosolic alkalization and extracellular acidification. Accumulating evidence suggests that in addition to the well-characterized ion pumps and exchangers in the plasma membrane, cancer cell lysosomes are also reprogrammed for this purpose. On the one hand, the increased expression and activity of the vacuolar-type H

Keywords: V-ATPase; lysosomal exocytosis; lysosome; pH regulation

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