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Batta V, Rao S, Wagh D, et al. Early neurodevelopmental outcomes of congenital gastrointestinal surgical conditions: a single-centre retrospective study. BMJ Paediatr Open. 2020;4(1):e000736doi: 10.1136/bmjpo-2020-000736.
Batta, V., Rao, S., Wagh, D., Tan, J. K. G., Gollow, I., Simmer, K., Bulsara, M. K., & Patole, S. (2020). Early neurodevelopmental outcomes of congenital gastrointestinal surgical conditions: a single-centre retrospective study. BMJ paediatrics open, 4(1), e000736. https://doi.org/10.1136/bmjpo-2020-000736
Batta, Vamsi, et al. "Early neurodevelopmental outcomes of congenital gastrointestinal surgical conditions: a single-centre retrospective study." BMJ paediatrics open vol. 4,1 (2020): e000736. doi: https://doi.org/10.1136/bmjpo-2020-000736
Batta V, Rao S, Wagh D, Tan JKG, Gollow I, Simmer K, Bulsara MK, Patole S. Early neurodevelopmental outcomes of congenital gastrointestinal surgical conditions: a single-centre retrospective study. BMJ Paediatr Open. 2020 Aug 11;4(1):e000736. doi: 10.1136/bmjpo-2020-000736. eCollection 2020. PMID: 32821861; PMCID: PMC7422631.
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BMJ Paediatr Open. 2020 Aug 11;4(1):e000736. doi: 10.1136/bmjpo-2020-000736. eCollection 2020.

Early neurodevelopmental outcomes of congenital gastrointestinal surgical conditions: a single-centre retrospective study.

BMJ paediatrics open

Vamsi Batta, Shripada Rao, Deepika Wagh, Jason Khay Ghim Tan, Ian Gollow, Karen Simmer, Max K Bulsara, Sanjay Patole

Affiliations

  1. Neonatal Directorate, Perth Children's Hospital and King Edward Memorial Hospital for Women, Perth, Western Australia, Australia.
  2. School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
  3. Paediatric Surgery, Perth Children's Hospital, Nedlands, Western Australia, Australia.
  4. Biostatistics, University of Notre Dame, Fremantle, Western Australia, Australia.

PMID: 32821861 PMCID: PMC7422631 DOI: 10.1136/bmjpo-2020-000736

Abstract

BACKGROUND: Evidence is emerging that surgery in the neonatal period is associated with increased risk of suboptimal neurodevelopmental outcomes (SNDO). The aim of this study was to describe neurodevelopmental outcomes (at 1 year) of neonatal surgery for congenital gastrointestinal surgical conditions (CGSC) and to explore risk factors.

METHODS: Retrospective study (2005-2014) of infants born ≥34 weeks gestation with CGSC and admitted to the surgical neonatal intensive care unit of Perth Children's Hospital, Western Australia. Clinical details and 1-year developmental outcomes based on Griffiths Mental Developmental Assessment Scales were collated from the database and by reviewing the medical records of study infants. SNDO was defined as one or more of the following: a general quotient less than 88 (ie, >1 SD below mean), cerebral palsy, blindness or sensorineural deafness. Univariable and multivariable logistic regression analyses were carried out to explore risk factors for SNDO. A total of 413 infants were included, of which 13 died. Median gestation was 37.6 weeks (IQR: 36.4-39.1). Information on developmental outcomes was available from 262 out of 400 survivors. A total of 43/262 (16.4%) had SNDO. On univariable analysis, lower z scores for birth weight, prolonged duration of antibiotics, increased episodes of general anaesthesia and prolonged duration of hospital stay were associated with SNDO. On multivariable analysis, lower z scores for birth weight and prolonged hospital stay were associated with increased risk of SNDO.

CONCLUSIONS: Late preterm and term infants undergoing neonatal surgery for CGSC may be at risk for SNDO. Studies with longer duration of follow-up are needed to further evaluate the role of potentially modifiable risk factors on their neurodevelopmental outcomes.

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: gastroenterology; neonatology

Conflict of interest statement

Competing interests: None declared.

References

  1. N Engl J Med. 2015 Feb 26;372(9):796-7 - PubMed
  2. Lancet. 2016 Jan 16;387(10015):239-50 - PubMed
  3. Epidemiology. 2007 Nov;18(6):805-35 - PubMed
  4. Arch Dis Child Fetal Neonatal Ed. 2013 May;98(3):F205-11 - PubMed
  5. JAMA. 2016 Jun 7;315(21):2312-20 - PubMed
  6. Fetal Diagn Ther. 2018;43(1):1-11 - PubMed
  7. J Pediatr Surg. 2010 Sep;45(9):1759-66 - PubMed
  8. J Paediatr Child Health. 2015 Dec;51(12):1221-5 - PubMed
  9. Dis Esophagus. 2014 May-Jun;27(4):330-4 - PubMed
  10. Psychol Bull. 2014 Sep;140(5):1332-60 - PubMed
  11. J Paediatr Child Health. 2014 Oct;50(10):E45-54 - PubMed
  12. J Hosp Infect. 2002 Dec;52(4):273-80 - PubMed
  13. Eur J Pediatr Surg. 2012 Feb;22(1):50-3 - PubMed
  14. Paediatr Anaesth. 2018 Jun;28(6):528-536 - PubMed
  15. Nat Rev Neurol. 2015 Apr;11(4):192-208 - PubMed
  16. Semin Pediatr Surg. 2016 Dec;25(6):347-370 - PubMed
  17. J Pediatr Surg. 2013 Oct;48(10):1995-2004 - PubMed
  18. J Pediatr. 2017 Aug;187:43-49.e1 - PubMed
  19. Eur J Clin Nutr. 2003 Apr;57(4):548-53 - PubMed
  20. Trends Mol Med. 2018 Sep;24(9):794-804 - PubMed
  21. J Pediatr Surg. 2016 May;51(5):743-7 - PubMed
  22. Early Hum Dev. 2013 Jun;89(6):393-400 - PubMed
  23. Anesthesiology. 2018 Jul;129(1):89-105 - PubMed
  24. Children (Basel). 2019 Dec 01;6(12): - PubMed
  25. Paediatr Anaesth. 2015 Jan;25(1):65-72 - PubMed
  26. J Pediatr Surg. 2015 Jul;50(7):1125-9 - PubMed
  27. J Infect Dis. 2015 Nov 1;212(9):1480-90 - PubMed
  28. Early Hum Dev. 2018 Feb;117:57-61 - PubMed
  29. J Pediatr Surg. 2005 Jan;40(1):36-45; discussion 45-6 - PubMed
  30. Ann Neurol. 2012 Apr;71(4):444-57 - PubMed

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