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de Marañón AM, Iannantuoni F, Abad-Jiménez Z, et al. Association between Proinflammatory Markers, Leukocyte-Endothelium Interactions, and Carotid Intima-Media Thickness in Type 2 Diabetes: Role of Glycemic Control. J Clin Med. 2020;9(8)doi: 10.3390/jcm9082522.
de Marañón, A. M., Iannantuoni, F., Abad-Jiménez, Z., Canet, F., Díaz-Pozo, P., López-Domènech, S., Roldán-Torres, I., Morillas, C., Rocha, M., & Víctor, V. M. (2020). Association between Proinflammatory Markers, Leukocyte-Endothelium Interactions, and Carotid Intima-Media Thickness in Type 2 Diabetes: Role of Glycemic Control. Journal of clinical medicine, 9(8), . https://doi.org/10.3390/jcm9082522
de Marañón, Aranzazu Martinez, et al. "Association between Proinflammatory Markers, Leukocyte-Endothelium Interactions, and Carotid Intima-Media Thickness in Type 2 Diabetes: Role of Glycemic Control." Journal of clinical medicine vol. 9,8 (2020). doi: https://doi.org/10.3390/jcm9082522
de Marañón AM, Iannantuoni F, Abad-Jiménez Z, Canet F, Díaz-Pozo P, López-Domènech S, Roldán-Torres I, Morillas C, Rocha M, Víctor VM. Association between Proinflammatory Markers, Leukocyte-Endothelium Interactions, and Carotid Intima-Media Thickness in Type 2 Diabetes: Role of Glycemic Control. J Clin Med. 2020 Aug 05;9(8). doi: 10.3390/jcm9082522. PMID: 32764458; PMCID: PMC7465892.
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J Clin Med. 2020 Aug 05;9(8). doi: 10.3390/jcm9082522.

Association between Proinflammatory Markers, Leukocyte-Endothelium Interactions, and Carotid Intima-Media Thickness in Type 2 Diabetes: Role of Glycemic Control.

Journal of clinical medicine

Aranzazu Martinez de Marañón, Francesca Iannantuoni, Zaida Abad-Jiménez, Francisco Canet, Pedro Díaz-Pozo, Sandra López-Domènech, Ildefonso Roldán-Torres, Carlos Morillas, Milagros Rocha, Víctor M Víctor

Affiliations

  1. Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain.
  2. Service of Cardiology, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain.
  3. Centro de Investigación Biomédica en Red (CIBERehd)-Department of Pharmacology, University of Valencia, 46010 Valencia, Spain.
  4. Department of Physiology, University of Valencia, 46010 Valencia, Spain.

PMID: 32764458 PMCID: PMC7465892 DOI: 10.3390/jcm9082522

Abstract

Glycated hemoglobin monitorization could be a tool for maintaining type 2 diabetes (T2D) under control and delaying the appearance of cardiovascular events. This cross-sectional study was designed to assess the role of glycemic control in modulating early-stage markers of cardiovascular complications. One hundred and eight healthy controls and 161 type 2 diabetic patients were recruited and distributed according to their glycemic control, setting the threshold at 6.5% (good control). Biochemical and anthropometrical parameters were registered during the initial visit, and peripheral blood was extracted to obtain polymorphonuclear cells and analyze inflammatory markers, adhesion molecules, leukocyte-endothelium interactions, and carotid intima-media thickness. Correlations between these parameters were explored. We found that inflammatory markers and adhesion molecules were augmented in type 2 diabetic subjects with poor glycemic control. Polymorphonuclear leukocytes interacted more with the endothelium in the diabetic population, and even more significantly in the poorly controlled subjects. In parallel, carotid intima-media thickness was also increased in the diabetic population, and the difference was greater among poorly controlled subjects. Finally, correlation measurement revealed that carotid intima-media thickness was related to glycemic control and lipid metabolism in diabetic patients. Our results suggest that glycemic control delays the onset of cardiovascular comorbidities in diabetic subjects.

Keywords: carotid intima–media thickness; endothelial function; glycated hemoglobin; inflammation; type 2 diabetes

References

  1. J Leukoc Biol. 2013 Oct;94(4):657-70 - PubMed
  2. Cell Mol Life Sci. 2013 Oct;70(20):3847-69 - PubMed
  3. N Engl J Med. 2008 Jun 12;358(24):2560-72 - PubMed
  4. Cardiovasc Diabetol. 2012 Jun 27;11:77 - PubMed
  5. Redox Biol. 2018 Apr;14:645-655 - PubMed
  6. Curr Pharm Des. 2009;15(26):2988-3002 - PubMed
  7. Atherosclerosis. 2017 May;260:34-40 - PubMed
  8. Biochem Pharmacol. 2019 Oct;168:452-464 - PubMed
  9. Nat Rev Endocrinol. 2018 Feb;14(2):88-98 - PubMed
  10. Stroke. 2014 Oct;45(10):2924-9 - PubMed
  11. Mediators Inflamm. 2015;2015:720457 - PubMed
  12. Oxid Med Cell Longev. 2018 Sep 30;2018:7514383 - PubMed
  13. PLoS One. 2011;6(7):e22480 - PubMed
  14. Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):238-251 - PubMed
  15. Eur J Intern Med. 2002 May;13(3):185-189 - PubMed
  16. J Diabetes Res. 2019 May 19;2019:1905194 - PubMed
  17. J Mol Endocrinol. 2004 Aug;33(1):59-72 - PubMed
  18. Oxid Med Cell Longev. 2017;2017:1249614 - PubMed
  19. PLoS One. 2019 Dec 17;14(12):e0226652 - PubMed
  20. J Cell Mol Med. 2018 Sep;22(9):4437-4448 - PubMed
  21. Lancet. 2014 Jun 7;383(9933):1999-2007 - PubMed
  22. Eur Heart J. 2020 Jan 7;41(2):255-323 - PubMed
  23. Hypertension. 2003 Jul;42(1):56-60 - PubMed
  24. J Clin Endocrinol Metab. 2006 Jan;91(1):336-40 - PubMed
  25. Diabetes. 2002 Oct;51(10):3069-76 - PubMed
  26. Clin Radiol. 2011 May;66(5):393-8 - PubMed
  27. Diabetologia. 2014 Oct;57(10):2030-7 - PubMed
  28. J Cell Biochem. 2017 Nov;118(11):3577-3585 - PubMed
  29. Heart Views. 2014 Oct-Dec;15(4):111-20 - PubMed
  30. Curr Diab Rep. 2013 Jun;13(3):435-44 - PubMed
  31. Diabetes Res Clin Pract. 2013 Feb;99(2):85-92 - PubMed
  32. Stroke. 2014 Nov;45(11):3226-30 - PubMed
  33. Annu Rev Immunol. 2009;27:165-97 - PubMed
  34. Int J Clin Pract. 2006 Sep;60(9):1138-45 - PubMed
  35. J Diabetes Res. 2019 Aug 8;2019:9051929 - PubMed
  36. J Biol Chem. 2013 Mar 8;288(10):6835-48 - PubMed
  37. Int J Vasc Med. 2012;2012:918267 - PubMed
  38. Cardiovasc Diabetol. 2012 Jul 16;11:51 - PubMed
  39. J Clin Neurol. 2013 Apr;9(2):97-102 - PubMed
  40. J Diabetes Metab Disord. 2015 Nov 10;14:84 - PubMed
  41. Diabetes Care. 2019 Mar;42(3):416-426 - PubMed
  42. Atherosclerosis. 2019 Aug;287:147-154 - PubMed
  43. Cardiovasc Diabetol. 2010 Aug 13;9:37 - PubMed
  44. Diabetes Obes Metab. 2010 Aug;12(8):641-7 - PubMed
  45. J Leukoc Biol. 2001 Jan;69(1):3-10 - PubMed
  46. Diabetes Care. 2011 Nov;34(11):2438-41 - PubMed
  47. Free Radic Biol Med. 2019 Feb 20;132:90-100 - PubMed
  48. Diabet Med. 2016 Jul;33(7):985-91 - PubMed
  49. J Atheroscler Thromb. 2016;23(1):18-31 - PubMed
  50. Diabetologia. 2020 Jan;63(1):21-33 - PubMed
  51. J Clin Med. 2019 Aug 28;8(9): - PubMed
  52. Nat Immunol. 2010 Feb;11(2):136-40 - PubMed
  53. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H37-47 - PubMed
  54. BMJ. 2011 Jul 26;343:d4169 - PubMed
  55. N Engl J Med. 1999 Jan 7;340(1):14-22 - PubMed
  56. Biochem Pharmacol. 2012 Sep 1;84(5):581-90 - PubMed
  57. Eur Heart J. 2002 Mar;23(5):376-83 - PubMed
  58. Circulation. 1986 Dec;74(6):1399-406 - PubMed
  59. Front Neurol. 2019 Jun 18;10:642 - PubMed
  60. Diabetes Care. 2013 Jun;36(6):1695-702 - PubMed
  61. Int J Cardiol. 2016 Feb 1;204:29-36 - PubMed
  62. Nat Rev Immunol. 2019 Dec;19(12):734-746 - PubMed
  63. Ann Intern Med. 2012 Mar 20;156(6):438-44 - PubMed
  64. Open Access Maced J Med Sci. 2016 Dec 15;4(4):630-635 - PubMed
  65. Lancet. 2016 Apr 9;387(10027):1513-1530 - PubMed
  66. Atherosclerosis. 2012 Mar;221(1):275-81 - PubMed
  67. Immunol Rev. 2000 Apr;174:160-71 - PubMed
  68. BMC Res Notes. 2016 May 23;9:281 - PubMed
  69. Front Physiol. 2018 Nov 01;9:1547 - PubMed
  70. Diabetologia. 2002 Feb;45(2):210-6 - PubMed
  71. Cardiovasc Endocrinol Metab. 2019 Sep 10;8(3):73-76 - PubMed
  72. Nat Rev Immunol. 2011 Feb;11(2):98-107 - PubMed
  73. Diabetes Care. 2008 Feb;31 Suppl 2:S215-21 - PubMed
  74. Cardiovasc Diabetol. 2019 Aug 23;18(1):109 - PubMed
  75. Int J Mol Sci. 2019 Sep 10;20(18): - PubMed
  76. Clin Cardiol. 2017 Sep;40(9):752-758 - PubMed
  77. Cardiovasc Diabetol. 2012 Aug 18;11:101 - PubMed
  78. J Diabetes Res. 2019 Feb 17;2019:2161085 - PubMed
  79. J Clin Med. 2019 Sep 04;8(9): - PubMed
  80. Oxid Med Cell Longev. 2015;2015:610813 - PubMed
  81. J Clin Invest. 2007 Jun;117(6):1718-26 - PubMed
  82. J Exp Med. 2011 Mar 14;208(3):519-33 - PubMed
  83. Cytokine. 2020 Jan;125:154832 - PubMed
  84. Innate Immun. 2017 May;23(4):345-372 - PubMed
  85. Free Radic Res. 2019 Jul;53(7):768-779 - PubMed
  86. Int Rev Immunol. 2018 May 4;37(3):129-143 - PubMed
  87. Br J Nutr. 2016 Jul;116(2):286-93 - PubMed
  88. Nat Clin Pract Cardiovasc Med. 2008 Dec;5(12):811-20 - PubMed
  89. Diabetes Care. 2018 Jan;41(Suppl 1):S55-S64 - PubMed
  90. Circ Res. 2018 Mar 16;122(6):877-902 - PubMed
  91. Diabetes Care. 2015 Oct;38(10):1921-9 - PubMed
  92. PLoS One. 2014 Aug 19;9(8):e104771 - PubMed
  93. Nature. 2011 Jan 13;469(7329):221-5 - PubMed
  94. Circulation. 1997 Apr 1;95(7):1783-90 - PubMed
  95. Swiss Med Wkly. 2012 Oct 25;142:w13705 - PubMed

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