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Novy Z, Lobaz V, Vlk M, et al. Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Nanomaterials (Basel). 2020;10(9)doi: 10.3390/nano10091690.
Novy, Z., Lobaz, V., Vlk, M., Kozempel, J., Stepanek, P., Popper, M., Vrbkova, J., Hajduch, M., Hruby, M., & Petrik, M. (2020). Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Nanomaterials (Basel, Switzerland), 10(9), . https://doi.org/10.3390/nano10091690
Novy, Zbynek, et al. "Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model." Nanomaterials (Basel, Switzerland) vol. 10,9 (2020). doi: https://doi.org/10.3390/nano10091690
Novy Z, Lobaz V, Vlk M, Kozempel J, Stepanek P, Popper M, Vrbkova J, Hajduch M, Hruby M, Petrik M. Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model. Nanomaterials (Basel). 2020 Aug 27;10(9). doi: 10.3390/nano10091690. PMID: 32867391; PMCID: PMC7558523.
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Nanomaterials (Basel). 2020 Aug 27;10(9). doi: 10.3390/nano10091690.

Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model.

Nanomaterials (Basel, Switzerland)

Zbynek Novy, Volodymyr Lobaz, Martin Vlk, Jan Kozempel, Petr Stepanek, Miroslav Popper, Jana Vrbkova, Marian Hajduch, Martin Hruby, Milos Petrik

Affiliations

  1. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 5, 779 00 Olomouc, Czech Republic.
  2. Institute of Macromolecular Chemistry AS CR, Heyrovskeho namesti 1888/2, 162 06 Prague 6, Czech Republic.
  3. Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Brehova 7, 115 19 Prague 1, Czech Republic.

PMID: 32867391 PMCID: PMC7558523 DOI: 10.3390/nano10091690

Abstract

Nanoparticles (NPs) represent an emerging platform for diagnosis and treatment of various diseases such as cancer, where they can take advantage of enhanced permeability and retention (EPR) effect for solid tumor accumulation. To improve their colloidal stability, prolong their blood circulation time and avoid premature entrapment into reticuloendothelial system, coating with hydrophilic biocompatible polymers is often essential. Most studies, however, employ just one type of coating polymer. The main purpose of this study is to head-to-head compare biological behavior of three leading polymers commonly used as "stealth" coating materials for biocompatibilization of NPs poly(ethylene oxide), poly(2-ethyl-2-oxazoline) and poly[

Keywords: animal model; hydroxyapatite; nanoparticles; poly(2-ethyl-2-oxazoline); poly(ethylene oxide); poly[N-(2-hydroxypropyl)methacrylamide]; solid tumor

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