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Calvo-Pinilla E, Marín-López A, Moreno S, et al. A protective bivalent vaccine against Rift Valley fever and bluetongue. NPJ Vaccines. 2020;5(1):70doi: 10.1038/s41541-020-00218-y.
Calvo-Pinilla, E., Marín-López, A., Moreno, S., Lorenzo, G., Utrilla-Trigo, S., Jiménez-Cabello, L., Benavides, J., Nogales, A., Blasco, R., Brun, A., & Ortego, J. (2020). A protective bivalent vaccine against Rift Valley fever and bluetongue. NPJ vaccines, 5(1), 70. https://doi.org/10.1038/s41541-020-00218-y
Calvo-Pinilla, Eva, et al. "A protective bivalent vaccine against Rift Valley fever and bluetongue." NPJ vaccines vol. 5,1 (2020): 70. doi: https://doi.org/10.1038/s41541-020-00218-y
Calvo-Pinilla E, Marín-López A, Moreno S, Lorenzo G, Utrilla-Trigo S, Jiménez-Cabello L, Benavides J, Nogales A, Blasco R, Brun A, Ortego J. A protective bivalent vaccine against Rift Valley fever and bluetongue. NPJ Vaccines. 2020 Jul 30;5(1):70. doi: 10.1038/s41541-020-00218-y. eCollection 2020. PMID: 32793399; PMCID: PMC7393076.
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NPJ Vaccines. 2020 Jul 30;5(1):70. doi: 10.1038/s41541-020-00218-y. eCollection 2020.

A protective bivalent vaccine against Rift Valley fever and bluetongue.

NPJ vaccines

Eva Calvo-Pinilla, Alejandro Marín-López, Sandra Moreno, Gema Lorenzo, Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Julio Benavides, Aitor Nogales, Rafael Blasco, Alejandro Brun, Javier Ortego

Affiliations

  1. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Centro de Investigación en Sanidad Animal (INIA-CISA), Madrid, Spain.
  2. Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT USA.
  3. Instituto de Ganadería de Montaña (CSIC-Universidad de León), León, Spain.
  4. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Departamento de Biotecnología, Madrid, Spain.

PMID: 32793399 PMCID: PMC7393076 DOI: 10.1038/s41541-020-00218-y

Abstract

Rift Valley fever (RVF) and bluetongue (BT) are two important ruminant diseases transmitted by arthropods. Both viruses have shown important geographic spread leading to endemicity of BT virus (BTV) in Africa and Europe. In this work, we report a dual vaccine that simultaneously induces protective immune responses against BTV and RVFV based on modified vaccinia Ankara virus (MVA) expressing BTV proteins VP2, NS1, or a truncated form of NS1 (NS1-Nt), and RVFV Gn and Gc glycoproteins. IFNAR

© The Author(s) 2020.

Keywords: Biotechnology; Immunology; Microbiology

Conflict of interest statement

Competing interestsThe authors declare no competing interests.

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