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Front Oncol. 2020 Jul 22;10:1174. doi: 10.3389/fonc.2020.01174. eCollection 2020.

Increased Dose to Organs in Urinary Tract Associates With Measures of Genitourinary Toxicity in Pooled Voxel-Based Analysis of 3 Randomized Phase III Trials.

Frontiers in oncology

Marco Marcello, James W Denham, Angel Kennedy, Annette Haworth, Allison Steigler, Peter B Greer, Lois C Holloway, Jason A Dowling, Michael G Jameson, Dale Roach, David J Joseph, Sarah L Gulliford, David P Dearnaley, Matthew R Sydes, Emma Hall, Martin A Ebert

Affiliations

  1. Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
  2. Department of Physics, University of Western Australia, Perth, WA, Australia.
  3. School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
  4. School of Physics, University of Sydney, Sydney, NSW, Australia.
  5. Prostate Cancer Trials Group, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
  6. School of Mathematical and Physical Sciences, University of Newcastle, Callaghan, NSW, Australia.
  7. Department of Radiation Oncology, Calvary Mater Newcastle, Waratah, NSW, Australia.
  8. Department of Medical Physics, Liverpool Cancer Centre, Liverpool, NSW, Australia.
  9. South Western Sydney Clinical School, University of New South Wales, Kensington, NSW, Australia.
  10. Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
  11. CSIRO, St Lucia, QLD, Australia.
  12. Cancer Research Team, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia.
  13. School of Surgery, University of Western Australia, Perth, WA, Australia.
  14. 5D Clinics, Claremont, WA, Australia.
  15. GenesisCare WA, Wembley, WA, Australia.
  16. Radiotherapy Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  17. Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
  18. Academic UroOncology Unit, The Institute of Cancer Research and the Royal Marsden NHS Trust, London, United Kingdom.
  19. MRC Clinical Trials Unit, Medical Research Council, London, United Kingdom.
  20. Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom.

PMID: 32793485 PMCID: PMC7387667 DOI: 10.3389/fonc.2020.01174

[No abstract available.]

Copyright © 2020 Marcello, Denham, Kennedy, Haworth, Steigler, Greer, Holloway, Dowling, Jameson, Roach, Joseph, Gulliford, Dearnaley, Sydes, Hall and Ebert.

Keywords: dose-toxicity relationships; external beam radiotherapy; prostate cancer; urinary toxicity; voxel-based analysis

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