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de Denus S, Mottet F, Korol S, et al. A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy. ESC Heart Fail. 2020;doi: 10.1002/ehf2.12934.
de Denus, S., Mottet, F., Korol, S., Feroz Zada, Y., Provost, S., Mongrain, I., Asselin, G., Oussaïd, E., Busseuil, D., Lettre, G., Rioux, J., Racine, N., O'Meara, E., White, M., Rouleau, J., Tardif, J. C., & Dubé, M. P. (2020). A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy. ESC heart failure, . https://doi.org/10.1002/ehf2.12934
de Denus, Simon, et al. "A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy." ESC heart failure vol. (2020). doi: https://doi.org/10.1002/ehf2.12934
de Denus S, Mottet F, Korol S, Feroz Zada Y, Provost S, Mongrain I, Asselin G, Oussaïd E, Busseuil D, Lettre G, Rioux J, Racine N, O'Meara E, White M, Rouleau J, Tardif JC, Dubé MP. A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy. ESC Heart Fail. 2020 Sep 01; doi: 10.1002/ehf2.12934. Epub 2020 Sep 01. PMID: 32869539; PMCID: PMC7754954.
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ESC Heart Fail. 2020 Sep 01; doi: 10.1002/ehf2.12934. Epub 2020 Sep 01.

A genetic association study of heart failure: more evidence for the role of BAG3 in idiopathic dilated cardiomyopathy.

ESC heart failure

Simon de Denus, Fannie Mottet, Sandra Korol, Yassamin Feroz Zada, Sylvie Provost, Ian Mongrain, Géraldine Asselin, Essaïd Oussaïd, David Busseuil, Guillaume Lettre, John Rioux, Normand Racine, Eileen O'Meara, Michel White, Jean Rouleau, Jean Claude Tardif, Marie-Pierre Dubé

Affiliations

  1. Montreal Heart Institute, 5000 Bélanger, Montreal, QC, H1T 1C8, Canada.
  2. Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.
  3. Université de Montreal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.
  4. Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.

PMID: 32869539 PMCID: PMC7754954 DOI: 10.1002/ehf2.12934

Abstract

AIMS: Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups.

METHODS AND RESULTS: We performed a case-control study to further investigate the potential impact of 14 previously reported candidate genes on the risk of HF and specific HF sub-types. We also performed an exploratory genome-wide study. We included 799 patients with HF and 1529 controls. After adjusting for age, sex, and genetic ancestry, we found that the C allele of rs2234962 in BAG3 was associated with a decreased risk of idiopathic dilated cardiomyopathy (odds ratio 0.42, 95% confidence interval 0.25-0.68, P = 0.0005), consistent with a previous report. No association for the other primary variants or exploratory genome-wide study was found.

CONCLUSIONS: Our findings provide independent replication for the association between a common coding variant (rs2234962) in BAG3 and the risk of idiopathic dilated cardiomyopathy.

© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

Keywords: B-cell lymphoma 2-associated anthanogene protein; Genetics; Heart failure

References

  1. Genet Epidemiol. 2008 May;32(4):361-9 - PubMed
  2. Nat Commun. 2020 Jan 9;11(1):163 - PubMed
  3. Circulation. 2020 Feb 4;141(5):387-398 - PubMed
  4. PLoS One. 2017 Mar 15;12(3):e0172995 - PubMed
  5. Nat Genet. 2014 Jun;46(6):629-34 - PubMed
  6. Circ Cardiovasc Genet. 2010 Apr;3(2):147-54 - PubMed
  7. ESC Heart Fail. 2020 Sep 1;: - PubMed
  8. N Engl J Med. 2006 Jul 13;355(2):138-47 - PubMed
  9. Circulation. 2019 Oct 15;140(16):1318-1330 - PubMed
  10. JACC Basic Transl Sci. 2018 Feb;3(1):122-131 - PubMed
  11. Eur Heart J. 2011 May;32(9):1065-76 - PubMed
  12. Heart Fail Rev. 2019 Dec 6;: - PubMed
  13. Pharmacogenomics J. 2017 Mar;17(2):192-200 - PubMed
  14. Hypertension. 1997 Nov;30(5):1025-8 - PubMed
  15. JAMA Cardiol. 2018 Oct 1;3(10):929-938 - PubMed
  16. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2456-61 - PubMed

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