Display options
Cite
Abad-Jiménez Z, López-Domènech S, Gómez-Abril SÁ, et al. Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study. Antioxidants (Basel). 2020;9(8)doi: 10.3390/antiox9080734.
Abad-Jiménez, Z., López-Domènech, S., Gómez-Abril, S. �. �., Periañez-Gómez, D., de Marañón, A. M., Bañuls, C., Morillas, C., Víctor, V. M., & Rocha, M. (2020). Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study. Antioxidants (Basel, Switzerland), 9(8), . https://doi.org/10.3390/antiox9080734
Abad-Jiménez, Zaida, et al. "Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study." Antioxidants (Basel, Switzerland) vol. 9,8 (2020). doi: https://doi.org/10.3390/antiox9080734
Abad-Jiménez Z, López-Domènech S, Gómez-Abril SÁ, Periañez-Gómez D, de Marañón AM, Bañuls C, Morillas C, Víctor VM, Rocha M. Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study. Antioxidants (Basel). 2020 Aug 11;9(8). doi: 10.3390/antiox9080734. PMID: 32796678; PMCID: PMC7464524.
Copy Download .nbib Format: NLM
Share it on

Antioxidants (Basel). 2020 Aug 11;9(8). doi: 10.3390/antiox9080734.

Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study.

Antioxidants (Basel, Switzerland)

Zaida Abad-Jiménez, Sandra López-Domènech, Segundo Ángel Gómez-Abril, Dolores Periañez-Gómez, Aranzazu M de Marañón, Celia Bañuls, Carlos Morillas, Víctor M Víctor, Milagros Rocha

Affiliations

  1. Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain.
  2. Department of General and Digestive System Surgery, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain.
  3. Department of Surgery, Faculty of Medicine and Dentistry, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain.
  4. CIBERehd-Department of Pharmacology, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain.
  5. Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.

PMID: 32796678 PMCID: PMC7464524 DOI: 10.3390/antiox9080734

Abstract

Little is known about the mechanisms underlying the cardioprotective effect of Roux en-Y gastric bypass (RYGB) surgery. Therefore, the aim of the present study was to investigate whether weight loss associated with RYGB improves the oxidative status of leukocytes and ameliorates subclinical atherosclerotic markers. This is an interventional study of 57 obese subjects who underwent RYGB surgery. We determined biochemical parameters and qualitative analysis of cholesterol, leukocyte and systemic oxidative stress markers -superoxide production, glutathione peroxidase 1 (GPX1), superoxide dismutase (SOD) activity and protein carbonylation-, soluble cellular adhesion molecules -sICAM-1 and sP-selectin-, myeloperoxidase (MPO) and leukocyte-endothelium cell interactions-rolling flux, velocity and adhesion. RYGB induced an improvement in metabolic parameters, including hsCRP and leukocyte count (

Keywords: atherosclerosis; bariatric surgery; leukocyte-endothelium interactions; obesity; oxidative stress

References

  1. Redox Biol. 2017 Aug;12:389-402 - PubMed
  2. Atherosclerosis. 2015 May;240(1):3-9 - PubMed
  3. Free Radic Biol Med. 2009 Nov 1;47(9):1254-66 - PubMed
  4. J Clin Endocrinol Metab. 2004 Jun;89(6):2595-600 - PubMed
  5. Diabetes Care. 2013 Jun;36(6):1695-702 - PubMed
  6. JAMA. 2012 Jan 4;307(1):56-65 - PubMed
  7. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1159-64 - PubMed
  8. Front Immunol. 2018 Mar 02;9:430 - PubMed
  9. Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1716-23 - PubMed
  10. Obes Surg. 2018 Jun;28(6):1611-1621 - PubMed
  11. N Engl J Med. 2002 Nov 14;347(20):1557-65 - PubMed
  12. Clin Biochem. 2002 Nov;35(8):627-31 - PubMed
  13. Diabetes. 2007 Apr;56(4):1010-3 - PubMed
  14. Obes Surg. 2016 Nov;26(11):2756-2763 - PubMed
  15. Eur J Clin Invest. 2018 Aug;48(8):e12985 - PubMed
  16. Diabetes Metab Syndr Obes. 2020 Feb 04;13:247-256 - PubMed
  17. Circulation. 2012 Sep 4;126(10):1301-13 - PubMed
  18. Int J Obes (Lond). 2019 Nov;43(11):2200-2209 - PubMed
  19. Endocrinol Metab Clin North Am. 2008 Sep;37(3):623-33, viii - PubMed
  20. Int J Mol Sci. 2017 Sep 22;18(10): - PubMed
  21. Hypertension. 2000 Sep;36(3):430-5 - PubMed
  22. JAMA. 2014 Sep 3;312(9):934-42 - PubMed
  23. Medicine (Baltimore). 2015 Oct;94(40):e1382 - PubMed
  24. J Physiol Pharmacol. 2006 Dec;57(4):505-28 - PubMed
  25. Int J Obes (Lond). 2016 Mar;40(3):395-402 - PubMed
  26. J Clin Med. 2019 Jul 26;8(8): - PubMed
  27. Circulation. 2004 Sep 21;110(12):1564-71 - PubMed
  28. JAMA. 2013 Jun 5;309(21):2240-9 - PubMed
  29. J Clin Lipidol. 2018 Jan - Feb;12(1):193-202 - PubMed
  30. Sci Rep. 2018 Oct 26;8(1):15862 - PubMed
  31. J Intern Med. 2007 Oct;262(4):408-14 - PubMed
  32. Blood. 2011 Jan 27;117(4):1350-8 - PubMed
  33. Eur J Clin Nutr. 2012 Aug;66(8):891-9 - PubMed
  34. Metabolism. 2017 Jun;71:153-162 - PubMed
  35. Clin Sci (Lond). 2017 Jun 30;131(14):1689-1700 - PubMed
  36. Curr Opin Lipidol. 2003 Aug;14(4):353-9 - PubMed
  37. Front Pharmacol. 2015 Oct 05;6:218 - PubMed
  38. Pharmacol Ther. 2006 Jul;111(1):16-26 - PubMed
  39. Mol Cell Biochem. 2015 Jan;399(1-2):95-103 - PubMed
  40. Lancet. 2009 Mar 28;373(9669):1083-96 - PubMed
  41. Obes Surg. 2010 Jan;20(1):42-9 - PubMed

Publication Types

Grant support