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Am J Physiol Lung Cell Mol Physiol. 2020 Oct 01;319(4):L710-L716. doi: 10.1152/ajplung.00360.2020. Epub 2020 Sep 02.

Recent advances in understanding the ecology of the lung microbiota and deciphering the gut-lung axis.

American journal of physiology. Lung cellular and molecular physiology

Kent A Willis, Justin D Stewart, Namasivayam Ambalavanan

Affiliations

  1. Division of Neonatology, Department of Pediatrics, College of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
  2. Department of Ecological Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  3. Department of Pathology, College of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
  4. Department of Cell, Developmental and Integrative Biology, College of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.

PMID: 32877224 PMCID: PMC7642895 DOI: 10.1152/ajplung.00360.2020

Abstract

A rapidly expanding new field of lung research has been produced by the emergence of culture-independent next-generation sequencing technologies. While pulmonary microbiome research lags behind the exploration of the microbiome in other organ systems, the field is maturing and has recently produced multiple exciting discoveries. In this mini-review, we will explore recent advances in our understanding of the lung microbiome and the gut-lung axis from an ecological perspective.

Keywords: bacteria; bronchopulmonary dysplasia; fungi; microbiome; mycobiome

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