Display options
Cite
Guru SR, Reddy KA, Rao RJ, et al. Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial. J Indian Soc Periodontol. 2020;24(3):244-252doi: 10.4103/jisp.jisp_207_19.
Guru, S. R., Reddy, K. A., Rao, R. J., Padmanabhan, S., Guru, R., & Srinivasa, T. S. (2020). Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial. Journal of Indian Society of Periodontology, 24(3), 244-252. https://doi.org/10.4103/jisp.jisp_207_19
Guru, Sanjeela Rakshith, et al. "Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial." Journal of Indian Society of Periodontology vol. 24,3 (2020): 244-252. doi: https://doi.org/10.4103/jisp.jisp_207_19
Guru SR, Reddy KA, Rao RJ, Padmanabhan S, Guru R, Srinivasa TS. Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial. J Indian Soc Periodontol. 2020 May-Jun;24(3):244-252. doi: 10.4103/jisp.jisp_207_19. Epub 2020 May 04. PMID: 32773975; PMCID: PMC7307465.
Copy Download .nbib Format: NLM
Share it on

J Indian Soc Periodontol. 2020 May-Jun;24(3):244-252. doi: 10.4103/jisp.jisp_207_19. Epub 2020 May 04.

Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial.

Journal of Indian Society of Periodontology

Sanjeela Rakshith Guru, K Adithya Reddy, Ravi J Rao, Shyam Padmanabhan, Rakshith Guru, T S Srinivasa

Affiliations

  1. Department of Periodontology, Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.
  2. Department of Periodontology, Bangalore Institute of Dental Science, Kalaburgi, Karnataka, India.
  3. Department of Prosthodontics, ESIC Dental College, Kalaburgi, Karnataka, India.
  4. Department of Periodontology, ESIC Dental College, Kalaburgi, Karnataka, India.

PMID: 32773975 PMCID: PMC7307465 DOI: 10.4103/jisp.jisp_207_19

Abstract

CONTEXT: Nanoparticles, owing to their smaller size, penetrate regions inaccessible to other delivery systems, such as periodontal pockets. Thus, the present study aimed to comparatively evaluate efficacy of 2% curcumin with nanocarrier and 1% chlorhexidine gel as a local drug delivery (LDD) in the treatment of periodontal pockets.

MATERIALS AND METHODS: Forty-five chronic periodontitis patients with pocket depth 5-7 mm in two or more teeth were selected. Full-mouth scaling and root planing (SRP) was done for all patients followed by random allocation to the three treatment groups, namely SRP group (Group 1), 2% curcumin with nanogel (Group 2), and 1% chlorhexidine gel (Group 3). Clinical parameter assessment and microbiological analysis of subgingival plaque samples for

RESULTS: The results showed that when the two LDD agents were used as an adjunct to SRP in chronic periodontitis, there was an improvement in all clinical parameters. Evaluation of microbiological parameters also showed a significant reduction in Aa, Pg, and Tf levels. Comparison of 2% turmeric extract with a nanocarrier system with 1% chlorhexidine gel showed that both the agents had a comparable antibacterial effect on the three selected periodontopathic bacteria.

CONCLUSION: The present study showed that both the LDD agents showed an effective improvement of clinical and microbiologic parameters. 2% curcumin delivered with a nanocarrier system showed results comparable to chlorhexidine gel and hence shows promising future as an LDD agent in the treatment of periodontal pockets.

Copyright: © 2020 Indian Society of Periodontology.

Keywords: Chlorhexidine; Pluronic F127; chronic periodontitis; curcumin; local drug delivery

Conflict of interest statement

There are no conflicts of interest.

References

  1. Int J Nanomedicine. 2016 Jan 18;11:285-97 - PubMed
  2. J Clin Diagn Res. 2014 Dec;8(12):ZC65-9 - PubMed
  3. J Clin Periodontol. 1998 Feb;25(2):134-44 - PubMed
  4. Mediators Inflamm. 2013;2013:329740 - PubMed
  5. J Indian Soc Periodontol. 2014 Sep;18(5):575-80 - PubMed
  6. ACS Nano. 2013 Sep 24;7(9):7442-7 - PubMed
  7. Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):341-353 - PubMed
  8. Nat Rev Drug Discov. 2002 Jan;1(1):77-84 - PubMed
  9. Periodontol 2000. 1997 Jun;14:9-11 - PubMed
  10. Curr Drug Targets. 2011 Mar 1;12(3):332-47 - PubMed
  11. J Clin Periodontol. 1997 May;24(5):324-34 - PubMed
  12. Saudi Pharm J. 2018 Jan;26(1):64-70 - PubMed
  13. J Periodontol. 1990 Sep;61(9):579-84 - PubMed
  14. J Agric Food Chem. 2011 Sep 14;59(17):9280-9 - PubMed
  15. J Contemp Dent Pract. 2011 Jul 01;12(4):221-4 - PubMed
  16. J Calif Dent Assoc. 2000 Mar;28(3):185-93 - PubMed
  17. Braz Dent J. 2001;12(3):209-13 - PubMed
  18. Oral Health Prev Dent. 2013;11(1):81-6 - PubMed
  19. Exp Mol Pathol. 2009 Jun;86(3):215-23 - PubMed
  20. Quintessence Int. 2015 Feb;46(2):133-7 - PubMed
  21. Food Funct. 2015 Mar;6(3):719-29 - PubMed
  22. Periodontol 2000. 2006;40:184-96 - PubMed
  23. J Periodontal Res. 2011 Apr;46(2):269-79 - PubMed
  24. J Indian Soc Periodontol. 2012 Jul;16(3):386-91 - PubMed
  25. Indian J Dent Res. 2017 Sep-Oct;28(5):560-565 - PubMed
  26. J Periodontol. 1999 Jun;70(6):574-80 - PubMed
  27. Periodontol 2000. 1996 Feb;10:5-11 - PubMed
  28. J Indian Soc Periodontol. 2011 Jan;15(1):35-8 - PubMed
  29. AAPS PharmSciTech. 2006 Sep 15;7(3):76 - PubMed
  30. J Control Release. 2002 Dec 13;85(1-3):51-9 - PubMed
  31. Pharmacogn Rev. 2015 Jul-Dec;9(18):87-92 - PubMed
  32. J Periodontol. 2000 May;71(5):803-9 - PubMed
  33. Periodontol 2000. 2018 Feb;76(1):85-96 - PubMed
  34. J Indian Soc Periodontol. 2013 Jul;17(4):439-43 - PubMed
  35. J Periodontol. 2016 Jan;87(1):83-90 - PubMed

Publication Types