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Barbeau LMO, Keulers TGH, Rouschop KMA. Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers. Cancers (Basel). 2020;12(9)doi: 10.3390/cancers12092463.
Barbeau, L. M. O., Keulers, T. G. H., & Rouschop, K. M. A. (2020). Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers. Cancers, 12(9), . https://doi.org/10.3390/cancers12092463
Barbeau, Lydie M O, et al. "Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers." Cancers vol. 12,9 (2020). doi: https://doi.org/10.3390/cancers12092463
Barbeau LMO, Keulers TGH, Rouschop KMA. Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers. Cancers (Basel). 2020 Aug 31;12(9). doi: 10.3390/cancers12092463. PMID: 32878084; PMCID: PMC7563256.
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Cancers (Basel). 2020 Aug 31;12(9). doi: 10.3390/cancers12092463.

Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers.

Cancers

Lydie M O Barbeau, Tom G H Keulers, Kasper M A Rouschop

Affiliations

  1. Department of Radiation Oncology (Maastro), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, 6200MD Maastricht, The Netherlands.

PMID: 32878084 PMCID: PMC7563256 DOI: 10.3390/cancers12092463

Abstract

Recent advances in cancer treatment modalities reveal the limitations of the prevalent "one-size-fits-all" therapies and emphasize the necessity to develop personalized approaches. In this perspective, identification of predictive biomarkers and intrinsic vulnerabilities are an important advancement for further therapeutic strategies. Autophagy is an important lysosomal degradation and recycling pathway that provides energy and macromolecular precursors to maintain cellular homeostasis. Although all cells require autophagy, several genetic and/or cellular changes elevate the dependence of cancer cells on autophagy for their survival and indicates that autophagy inhibition in these tumors could provide a favorable addition to current therapies. In this context, we review the current literature on tumor (sub)types with elevated dependence on autophagy for their survival and highlight an exploitable vulnerability. We provide an inventory of microenvironmental factors, genetic alterations and therapies that may be exploited with autophagy-targeted approaches to improve efficacy of conventional anti-tumor therapies.

Keywords: autophagy-addiction; biomarkers; cancer; personalized medicine

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