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Najjari A, Rahimi H, Nojoumi SA, et al. Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. Int J Mol Cell Med. 2020;9(1):90-103doi: 10.22088/IJMCM.BUMS.9.1.90.
Najjari, A., Rahimi, H., Nojoumi, S. A., & Omidinia, E. (2020). Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. International journal of molecular and cellular medicine, 9(1), 90-103. https://doi.org/10.22088/IJMCM.BUMS.9.1.90
Najjari, Abbas, et al. "Computational Approach for Rational Design of Fusion Uricase with PAS Sequences." International journal of molecular and cellular medicine vol. 9,1 (2020): 90-103. doi: https://doi.org/10.22088/IJMCM.BUMS.9.1.90
Najjari A, Rahimi H, Nojoumi SA, Omidinia E. Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. Int J Mol Cell Med. 2020;9(1):90-103. doi: 10.22088/IJMCM.BUMS.9.1.90. PMID: 32832488; PMCID: PMC7422847.
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Int J Mol Cell Med. 2020;9(1):90-103. doi: 10.22088/IJMCM.BUMS.9.1.90.

Computational Approach for Rational Design of Fusion Uricase with PAS Sequences.

International journal of molecular and cellular medicine

Abbas Najjari, Hamzeh Rahimi, Seyed Ali Nojoumi, Eskandar Omidinia

Affiliations

  1. Enzyme Technology Laboratory, Department of Biochemistry,Genetic and Metabolism Research Group, Pasteur Institute of Iran,Tehran, Iran.
  2. Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran.
  3. Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran.

PMID: 32832488 PMCID: PMC7422847 DOI: 10.22088/IJMCM.BUMS.9.1.90

Abstract

Tumor lysis syndrome is a life-threatening condition for humans due to the lack of urate oxidase. In this study, several variants of PASylated uricase from the

Keywords: Aspergillus flavus; PASylation; Tumor lysis syndrome; molecular dynamic; plasma half-life; uricase

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