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Vázquez Marrero VR, Berríos CP, Dios Rodríguez L, et al. In the Context of Polymorphism: Accurate Measurement, and Validation of Solubility Data. Cryst Growth Des. 2019;19(7):4101-4108doi: 10.1021/acs.cgd.9b00529.
Vázquez Marrero, V. R., Berríos, C. P., Dios Rodríguez, L., Stelzer, T., & López-Mejías, V. (2019). In the Context of Polymorphism: Accurate Measurement, and Validation of Solubility Data. Crystal growth & design, 19(7), 4101-4108. https://doi.org/10.1021/acs.cgd.9b00529
Vázquez Marrero, Víctor R, et al. "In the Context of Polymorphism: Accurate Measurement, and Validation of Solubility Data." Crystal growth & design vol. 19,7 (2019): 4101-4108. doi: https://doi.org/10.1021/acs.cgd.9b00529
Vázquez Marrero VR, Berríos CP, Dios Rodríguez L, Stelzer T, López-Mejías V. In the Context of Polymorphism: Accurate Measurement, and Validation of Solubility Data. Cryst Growth Des. 2019;19(7):4101-4108. doi: 10.1021/acs.cgd.9b00529. Epub 2019 Jun 07. PMID: 32863778; PMCID: PMC7453630.
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Cryst Growth Des. 2019;19(7):4101-4108. doi: 10.1021/acs.cgd.9b00529. Epub 2019 Jun 07.

In the Context of Polymorphism: Accurate Measurement, and Validation of Solubility Data.

Crystal growth & design

Víctor R Vázquez Marrero, Carmen Piñero Berríos, Luz De Dios Rodríguez, Torsten Stelzer, Vilmalí López-Mejías

Affiliations

  1. Department of Biology, University of Puerto Rico-Río Piedras Campus, San Juan, Puerto Rico 00931, United States.
  2. Crystallization Design Institute, Molecular Sciences Research Center, University of Puerto Rico, San Juan, Puerto Rico 00926, United States.
  3. Department of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan, Puerto Rico 00931, United States.
  4. Department of Pharmaceutical Sciences, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico 00936, United States.

PMID: 32863778 PMCID: PMC7453630 DOI: 10.1021/acs.cgd.9b00529

Abstract

Solubility measurements for polymorphic compounds are often accompanied by solvent-mediated phase transformations. In this study, solubility measurements from undersaturated solutions are employed to investigate the solubility of the two most stable polymorphs of flufenamic acid (FFA forms I and III), tolfenamic acid (TA forms I and II), and the only known form of niflumic acid (NA). The solubility was measured from 278.15 to 333.15 K in four alcohols of a homologous series (methanol, ethanol, 1-propanol,

Conflict of interest statement

The authors declare no competing financial interest.

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