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Polcz M, Hocking KM, Chang D, et al. A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model. JRSM Cardiovasc Dis. 2020;9:2048004020940857doi: 10.1177/2048004020940857.
Polcz, M., Hocking, K. M., Chang, D., Leisy, P., Sobey, J. H., Huston, J., Eagle, S., Brophy, C., & Alvis, B. D. (2020). A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model. JRSM cardiovascular disease, 92048004020940857. https://doi.org/10.1177/2048004020940857
Polcz, Monica, et al. "A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model." JRSM cardiovascular disease vol. 9 (2020): 2048004020940857. doi: https://doi.org/10.1177/2048004020940857
Polcz M, Hocking KM, Chang D, Leisy P, Sobey JH, Huston J, Eagle S, Brophy C, Alvis BD. A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model. JRSM Cardiovasc Dis. 2020 Aug 02;9:2048004020940857. doi: 10.1177/2048004020940857. eCollection 2020. PMID: 32864123; PMCID: PMC7430072.
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JRSM Cardiovasc Dis. 2020 Aug 02;9:2048004020940857. doi: 10.1177/2048004020940857. eCollection 2020.

A brief report on the effects of vasoactive agents on peripheral venous waveforms in a porcine model.

JRSM cardiovascular disease

Monica Polcz, Kyle M Hocking, Devin Chang, Philip Leisy, Jenna H Sobey, Jessica Huston, Susan Eagle, Colleen Brophy, Bret D Alvis

Affiliations

  1. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  2. Department of Bioengineering, Vanderbilt University, Nashville, TN, USA.
  3. Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  4. Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

PMID: 32864123 PMCID: PMC7430072 DOI: 10.1177/2048004020940857

Abstract

OBJECTIVES: Non-invasive venous waveform analysis (NIVA) is a recently described, novel technique to assess intravascular volume status. Waveforms are captured with a piezoelectric sensor; analysis in the frequency domain allows for calculation of a "NIVA value" that represents volume status. The aim of this report was to determine the effects of vasoactive agents on the venous waveform and calculated NIVA values.

DESIGN: Porcine experimental model.

SETTING: Operating theatre.

PARTICIPANTS: A piezoelectric sensor was secured over the surgically exposed saphenous vein in eight anesthetized pigs.

MAIN OUTCOME MEASURES: NIVA value, pulmonary capillary wedge pressure (PCWP), and mean arterial pressure prior to and post intravenous administration of 150-180 µg of phenylephrine or 100 µg of sodium nitroprusside.

RESULTS: Phenylephrine led to a decrease in NIVA value (mean 9.2 vs. 4.6,

CONCLUSIONS: Vasoactive agents lead to changes in non-invasively obtained venous waveforms in euvolemic pigs, highlighting a potential limitation in the ability to NIVA to estimate static volume in this setting. Further studies are indicated to understand the effects of vasoactive agents in the setting of hypovolemia and hypervolemia.

© The Author(s) 2020.

Keywords: Animal models of human disease; basic science research; cardiology; other vascular biology; vascular biology

References

  1. BMC Nephrol. 2020 May 24;21(1):194 - PubMed
  2. Shock. 2016 Oct;46(4):447-52 - PubMed
  3. J Card Fail. 2018 Aug;24(8):525-532 - PubMed
  4. Anesthesiology. 2008 Apr;108(4):735-48 - PubMed
  5. J Card Fail. 2020 Feb;26(2):136-141 - PubMed
  6. J Clin Anesth. 2020 May;61:109664 - PubMed
  7. Br J Anaesth. 2017 Dec 1;119(6):1135-1140 - PubMed

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