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Wercberger R, Basbaum AI. Spinal cord projection neurons: a superficial, and also deep, analysis. Curr Opin Physiol. 2019;11:109-115doi: 10.1016/j.cophys.2019.10.002.
Wercberger, R., & Basbaum, A. I. (2019). Spinal cord projection neurons: a superficial, and also deep, analysis. Current opinion in physiology, 11109-115. https://doi.org/10.1016/j.cophys.2019.10.002
Wercberger, Racheli, and Basbaum, Allan I. "Spinal cord projection neurons: a superficial, and also deep, analysis." Current opinion in physiology vol. 11 (2019): 109-115. doi: https://doi.org/10.1016/j.cophys.2019.10.002
Wercberger R, Basbaum AI. Spinal cord projection neurons: a superficial, and also deep, analysis. Curr Opin Physiol. 2019 Oct;11:109-115. doi: 10.1016/j.cophys.2019.10.002. Epub 2019 Oct 10. PMID: 32864531; PMCID: PMC7450810.
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Curr Opin Physiol. 2019 Oct;11:109-115. doi: 10.1016/j.cophys.2019.10.002. Epub 2019 Oct 10.

Spinal cord projection neurons: a superficial, and also deep, analysis.

Current opinion in physiology

Racheli Wercberger, Allan I Basbaum

Affiliations

  1. Department of Anatomy and Neuroscience Graduate Program, University California San Francisco, San Francisco, CA 94158.

PMID: 32864531 PMCID: PMC7450810 DOI: 10.1016/j.cophys.2019.10.002

Abstract

Today there are extensive maps of the molecular heterogeneity of primary afferents and dorsal horn interneurons, yet there is a dearth of molecular and functional information regarding the projection neurons that transmit pain and itch information to the brain. Additionally, most contemporary research into the spinal cord and medullary projection neurons focuses on neurons in the superficial dorsal horn; the contribution of deep dorsal horn and even ventral horn projection neurons to pain and itch processing is often overlooked. In the present review we integrate conclusions from classical as well as contemporary studies and provide a more balanced view of the diversity of projection neurons. A major question addressed is the extent to which labeled-lines are maintained in these different populations or whether the brain generates distinct pain and itch percepts by decoding complex convergent inputs that engage projection neurons.

Keywords: Dorsal horn; Itch; Labeled line; Pain; Parabrachial; Spinoreticular; Spinothalamic

Conflict of interest statement

Declaration of interest The authors declare no competing interests.

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