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Das KK, Hasak S, Elhanafi S, et al. Performance and Predictors of Migration of Partially and Fully Covered Esophageal Self-Expanding Metal Stents for Malignant Dysphagia. Clin Gastroenterol Hepatol. 2020;19(12):2656-2663.e2doi: 10.1016/j.cgh.2020.09.010.
Das, K. K., Hasak, S., Elhanafi, S., Visrodia, K. H., Ginsberg, G. G., Ahmad, N. A., Hollander, T., Lang, G., Kushnir, V. M., Mullady, D. K., Abu Dayyeh, B. K., Buttar, N. S., Wong Kee Song, L. M., Kochman, M. L., & Chandrasekhara, V. (2021). Performance and Predictors of Migration of Partially and Fully Covered Esophageal Self-Expanding Metal Stents for Malignant Dysphagia. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 19(12), 2656-2663.e2. https://doi.org/10.1016/j.cgh.2020.09.010
Das, Koushik K, et al. "Performance and Predictors of Migration of Partially and Fully Covered Esophageal Self-Expanding Metal Stents for Malignant Dysphagia." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association vol. 19,12 (2021): 2656-2663.e2. doi: https://doi.org/10.1016/j.cgh.2020.09.010
Das KK, Hasak S, Elhanafi S, Visrodia KH, Ginsberg GG, Ahmad NA, Hollander T, Lang G, Kushnir VM, Mullady DK, Abu Dayyeh BK, Buttar NS, Wong Kee Song LM, Kochman ML, Chandrasekhara V. Performance and Predictors of Migration of Partially and Fully Covered Esophageal Self-Expanding Metal Stents for Malignant Dysphagia. Clin Gastroenterol Hepatol. 2021 Dec;19(12):2656-2663.e2. doi: 10.1016/j.cgh.2020.09.010. Epub 2020 Sep 06. PMID: 32898705.
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Clin Gastroenterol Hepatol. 2021 Dec;19(12):2656-2663.e2. doi: 10.1016/j.cgh.2020.09.010. Epub 2020 Sep 06.

Performance and Predictors of Migration of Partially and Fully Covered Esophageal Self-Expanding Metal Stents for Malignant Dysphagia.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Koushik K Das, Stephen Hasak, Sherif Elhanafi, Kavel H Visrodia, Gregory G Ginsberg, Nuzhat A Ahmad, Thomas Hollander, Gabriel Lang, Vladimir M Kushnir, Daniel K Mullady, Barham K Abu Dayyeh, Navtej S Buttar, Louis Michel Wong Kee Song, Michael L Kochman, Vinay Chandrasekhara

Affiliations

  1. Division of Gastroenterology, Washington University, St. Louis, Missouri. Electronic address: [email protected].
  2. Division of Gastroenterology, Washington University, St. Louis, Missouri.
  3. Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, Texas.
  4. Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
  5. Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  6. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

PMID: 32898705 DOI: 10.1016/j.cgh.2020.09.010

Abstract

BACKGROUND & AIMS: Self-expanding metal stents (SEMS) are routinely used to palliate malignant dysphagia. However esophageal SEMS can migrate or obstruct due to epithelial hyperplasia. The aim of this study was to evaluate the rates and factors predicting migration and obstruction, and the nutritional outcomes in partially covered (pc) vs. fully covered (fc) SEMS vs. fcSEMS with antimigration fins (AF) placed for malignant dysphagia.

METHODS: A retrospective review of consecutive patients undergoing SEMS placement for malignant dysphagia at three academic medical centers.

RESULTS: Among 357 patients, there were 55 (15.4%) stent migrations, 45 (12.6%) obstructions from epithelial hyperplasia, and 20 (5.6%) food impactions. Median overall survival was 79 days (IQR 41,199). The percent weight change/change in albumin at 30 and 60 days after SEMS placement were -2.24%/-0.544 g/dL and -2.98%/-0.55 g/dL, respectively. Stent migration occurred significantly more often with fcSEMS than pcSEMS (25.3% vs 10.9%; P < .003), but there was no difference when either group was compared to fcSEMS-AF (19.3%). The overall rate of epithelial hyperplasia resulting in stent obstruction was low (12.6%) and not different between stent types. Factors associated with increased risk of SEMS migration on multivariable logistic regression included stricture traversability with a diagnostic endoscope (OR, 2.37; 95% CI, 1.29-4.35) and use of fcSEMS (OR, 2.56; 1.31-5.00) or fcSEMS-AF (OR, 2.30, 1.03-5.14).

CONCLUSIONS: Traversability of a malignant esophageal stenosis predicts SEMS migration. In these patients with a limited overall survival, pcSEMS are associated with lower rates of stent migration and similar rates of obstruction compared to fcSEMS.

Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

Keywords: Esophageal Obstruction Palliation; Esophageal Stent; Stent Migration; Traversability

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