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Lazzarino G, Amorini AM, Barnes NM, et al. Low Molecular Weight Dextran Sulfate (ILB. Antioxidants (Basel). 2020;9(9)doi: 10.3390/antiox9090850.
Lazzarino, G., Amorini, A. M., Barnes, N. M., Bruce, L., Mordente, A., Lazzarino, G., Pietro, V. D., Tavazzi, B., Belli, A., & Logan, A. (2020). Low Molecular Weight Dextran Sulfate (ILB. Antioxidants (Basel, Switzerland), 9(9), . https://doi.org/10.3390/antiox9090850
Lazzarino, Giacomo, et al. "Low Molecular Weight Dextran Sulfate (ILB." Antioxidants (Basel, Switzerland) vol. 9,9 (2020). doi: https://doi.org/10.3390/antiox9090850
Lazzarino G, Amorini AM, Barnes NM, Bruce L, Mordente A, Lazzarino G, Pietro VD, Tavazzi B, Belli A, Logan A. Low Molecular Weight Dextran Sulfate (ILB. Antioxidants (Basel). 2020 Sep 10;9(9). doi: 10.3390/antiox9090850. PMID: 32927770; PMCID: PMC7555574.
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Antioxidants (Basel). 2020 Sep 10;9(9). doi: 10.3390/antiox9090850.

Low Molecular Weight Dextran Sulfate (ILB.

Antioxidants (Basel, Switzerland)

Giacomo Lazzarino, Angela Maria Amorini, Nicholas M Barnes, Lars Bruce, Alvaro Mordente, Giuseppe Lazzarino, Valentina Di Pietro, Barbara Tavazzi, Antonio Belli, Ann Logan

Affiliations

  1. UniCamillus-Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.
  2. Department of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, Via S. Sofia 97, 95123 Catania, Italy.
  3. National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
  4. Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  5. Tikomed AB, 26303 Viken, Sweden.
  6. Department of Basic Biotechnological Sciences, Intensive and Perioperative Clinics, Catholic University of the Sacred Heart of Rome, Largo F. Vito 1, 00168 Rome, Italy.
  7. Department of Laboratory Sciences and Infectious Disease, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy.
  8. Neurotrauma and Ophthalmology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  9. Axolotl Consulting Ltd., Droitwich, Worcestershire WR9 0JS, UK.

PMID: 32927770 PMCID: PMC7555574 DOI: 10.3390/antiox9090850

Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability in people less than 40 years of age in Western countries. Currently, there are no satisfying pharmacological treatments for TBI patients. In this study, we subjected rats to severe TBI (sTBI), testing the effects of a single subcutaneous administration, 30 min post-impact, of a new low molecular weight dextran sulfate, named ILB

Keywords: HPLC; N-acetylaspartate; ascorbate; energy metabolism; low molecular weight dextran sulfate; mitochondrial dysfunction; nicotinic coenzymes; oxidative/nitrosative stress; reduced glutathione (GSH); severe traumatic brain injury

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