Display options
Cite
Biteghe FAN, Chalomie NET, Mungra N, et al. Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma. Biomedicines. 2020;8(9)doi: 10.3390/biomedicines8090327.
Biteghe, F. A. N., Chalomie, N. E. T., Mungra, N., Vignaux, G., Gao, N., Vergeade, A., Okem, A., Naran, K., Ndong, J. C., & Barth, S. (2020). Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma. Biomedicines, 8(9), . https://doi.org/10.3390/biomedicines8090327
Biteghe, Fleury Augustin Nsole, et al. "Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma." Biomedicines vol. 8,9 (2020). doi: https://doi.org/10.3390/biomedicines8090327
Biteghe FAN, Chalomie NET, Mungra N, Vignaux G, Gao N, Vergeade A, Okem A, Naran K, Ndong JC, Barth S. Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma. Biomedicines. 2020 Sep 03;8(9). doi: 10.3390/biomedicines8090327. PMID: 32899183; PMCID: PMC7555584.
Copy Download .nbib Format: NLM
Share it on

Biomedicines. 2020 Sep 03;8(9). doi: 10.3390/biomedicines8090327.

Antibody-Based Immunotherapy: Alternative Approaches for the Treatment of Metastatic Melanoma.

Biomedicines

Fleury Augustin Nsole Biteghe, Nyangone Ekome Toung Chalomie, Neelakshi Mungra, Guillaume Vignaux, Nan Gao, Aurelia Vergeade, Ambrose Okem, Krupa Naran, Jean De La Croix Ndong, Stefan Barth

Affiliations

  1. Department of Radiation Oncology and Biomedical Sciences, Cedars-Sinai Medical, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
  2. Zhongshan Medical School, Sun Yat-Sen University, Guangzhou 510275, China.
  3. Medical Biotechnology & Immunotherapy Research Unit, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7700, South Africa.
  4. Arctic Slope Regional Corporation (ASRC) Federal, Beltsville, MD 20705, USA.
  5. School of Arts and Science, Rutgers University, New Brunswick, NJ 08901, USA.
  6. Department of Clinics and Pharmacology, Vanderbilt Medical Center, Nashville, TN 37232, USA.
  7. Department of Anaesthesia, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg 2193, South Africa.
  8. Department of Orthopedic Surgery, School of Medicine, New York University, New York, NY 10003, USA.
  9. Cancer Biotechnology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town 7700, South Africa.

PMID: 32899183 PMCID: PMC7555584 DOI: 10.3390/biomedicines8090327

Abstract

Melanoma is the least common form of skin cancer and is associated with the highest mortality. Where melanoma is mostly unresponsive to conventional therapies (e.g., chemotherapy), BRAF inhibitor treatment has shown improved therapeutic outcomes. Photodynamic therapy (PDT) relies on a light-activated compound to produce death-inducing amounts of reactive oxygen species (ROS). Their capacity to selectively accumulate in tumor cells has been confirmed in melanoma treatment with some encouraging results. However, this treatment approach has not reached clinical fruition for melanoma due to major limitations associated with the development of resistance and subsequent side effects. These adverse effects might be bypassed by immunotherapy in the form of antibody-drug conjugates (ADCs) relying on the ability of monoclonal antibodies (mAbs) to target specific tumor-associated antigens (TAAs) and to be used as carriers to specifically deliver cytotoxic warheads into corresponding tumor cells. Of late, the continued refinement of ADC therapeutic efficacy has given rise to photoimmunotherapy (PIT) (a light-sensitive compound conjugated to mAbs), which by virtue of requiring light activation only exerts its toxic effect on light-irradiated cells. As such, this review aims to highlight the potential clinical benefits of various armed antibody-based immunotherapies, including PDT, as alternative approaches for the treatment of metastatic melanoma.

Keywords: antibody–drug conjugates (ADCs); photodynamic therapy (PDT); photoimmunotherapy (PIT); skin cancer (melanoma)

References

  1. Bone Marrow Res. 2011;2011:924058 - PubMed
  2. Semin Oncol. 1999 Oct;26(5 Suppl 14):74-8 - PubMed
  3. Proc Natl Acad Sci U S A. 1989 Dec;86(24):10029-33 - PubMed
  4. Theranostics. 2013 Apr 23;3(6):357-65 - PubMed
  5. Ann Transl Med. 2016 Jun;4(12):237 - PubMed
  6. Chem Commun (Camb). 2014 Nov 18;50(89):13735-8 - PubMed
  7. Hematol Oncol Clin North Am. 2014 Jun;28(3):585-600 - PubMed
  8. Cancer Res. 2016 Nov 1;76(21):6331-6339 - PubMed
  9. J Pharm Sci. 2016 Feb;105(2):417-430 - PubMed
  10. Immunotherapy. 2014;6(12):1265-78 - PubMed
  11. Cancer Lett. 2016 Oct 28;381(2):323-30 - PubMed
  12. Photodiagnosis Photodyn Ther. 2019 Jun;26:375-382 - PubMed
  13. Nat Med. 2000 Apr;6(4):443-6 - PubMed
  14. MAbs. 2010 May-Jun;2(3):233-55 - PubMed
  15. Int J Cancer. 2018 Jun 1;142(11):2363-2374 - PubMed
  16. J Immunother Cancer. 2019 Dec 16;7(1):350 - PubMed
  17. Nat Chem. 2016 Mar;8(3):281 - PubMed
  18. Neurosurg Focus. 2006 Apr 15;20(4):E20 - PubMed
  19. Cancer Immunol Immunother. 2018 Jun;67(6):917-924 - PubMed
  20. Exp Mol Med. 2018 Dec 13;50(12):1-11 - PubMed
  21. Br J Cancer. 2003 Jun 2;88(11):1772-9 - PubMed
  22. Nat Commun. 2016 Aug 17;7:12499 - PubMed
  23. Anticancer Res. 2008 Jul-Aug;28(4B):2033-8 - PubMed
  24. Pathol Res Pract. 2019 Dec;215(12):152691 - PubMed
  25. J Natl Cancer Inst. 1998 Jun 17;90(12):889-905 - PubMed
  26. N Engl J Med. 2012 Jul 12;367(2):107-14 - PubMed
  27. J Cancer Res Clin Oncol. 2016 May;142(5):1003-11 - PubMed
  28. Semin Oncol. 1999 Oct;26(5 Suppl 14):58-65 - PubMed
  29. Protein Eng Des Sel. 2006 Jul;19(7):309-16 - PubMed
  30. Biotechnol Lett. 2016 Oct;38(10):1655-64 - PubMed
  31. Lasers Surg Med. 2010 Dec;42(10):766-76 - PubMed
  32. Br J Dermatol. 2006 Dec;155(6):1287-92 - PubMed
  33. Bioconjug Chem. 2014 Apr 16;25(4):656-64 - PubMed
  34. Nat Commun. 2020 Apr 20;11(1):1897 - PubMed
  35. Laryngoscope. 1994 Dec;104(12):1471-6 - PubMed
  36. Chem Biol. 2008 Feb;15(2):128-36 - PubMed
  37. J Control Release. 2018 May 10;277:48-56 - PubMed
  38. Photochem Photobiol. 2008 Jan-Feb;84(1):120-7 - PubMed
  39. Melanoma Res. 2014 Aug;24(4):401-3 - PubMed
  40. J Neurosurg. 1996 Aug;85(2):329-34 - PubMed
  41. Exp Dermatol. 2018 Dec;27(12):1315-1321 - PubMed
  42. Cancers (Basel). 2017 Feb 18;9(2): - PubMed
  43. An Bras Dermatol. 2014 Mar-Apr;89(2):301-10 - PubMed
  44. Photodiagnosis Photodyn Ther. 2012 Dec;9(4):321-31 - PubMed
  45. Cancer Res. 2004 Mar 15;64(6):2120-6 - PubMed
  46. Cancer Immunol Immunother. 2015 Mar;64(3):287-97 - PubMed
  47. BMC Cancer. 2018 Jun 22;18(1):675 - PubMed
  48. PLoS One. 2015 Mar 23;10(3):e0121989 - PubMed
  49. Methods Mol Biol. 2019;1904:1-10 - PubMed
  50. Lancet. 2010 Feb 20;375(9715):673-85 - PubMed
  51. Folia Histochem Cytobiol. 2005;43(3):129-32 - PubMed
  52. Cancer Biol Ther. 2010 Dec 1;10(11):1081-7 - PubMed
  53. Int J Biol Sci. 2016 Jan 01;12(1):120-32 - PubMed
  54. Cancer Treat Rev. 2018 Jan;62:39-49 - PubMed
  55. Int J Mol Sci. 2010 Feb 04;11(2):562-94 - PubMed
  56. Nano Lett. 2016 Sep 14;16(9):5503-13 - PubMed
  57. J Clin Pharmacol. 2017 Oct;57 Suppl 10:S11-S25 - PubMed
  58. J Mol Biol. 1994 Jan 21;235(3):959-73 - PubMed
  59. J Biol Chem. 2003 Aug 22;278(34):32413-22 - PubMed
  60. Adv Cancer Res. 2014;124:235-56 - PubMed
  61. Ther Clin Risk Manag. 2018 Jul 26;14:1299-1313 - PubMed
  62. Curr Opin Immunol. 1999 Oct;11(5):548-57 - PubMed
  63. Front Immunol. 2019 Nov 08;10:2614 - PubMed
  64. Acta Pharmacol Sin. 2005 Jun;26(6):641-8 - PubMed
  65. Int J Biol Sci. 2019 Sep 7;15(12):2548-2560 - PubMed
  66. Technol Cancer Res Treat. 2005 Jun;4(3):283-93 - PubMed
  67. Curr Gene Ther. 2010 Apr;10(2):77-90 - PubMed
  68. Photodiagnosis Photodyn Ther. 2018 Dec;24:332-341 - PubMed
  69. Photochem Photobiol. 2001 Aug;74(2):164-71 - PubMed
  70. J Pharm Pharm Sci. 2014;17(1):154-68 - PubMed
  71. Cancer Biol Ther. 2016 Apr 2;17(4):346-54 - PubMed
  72. ACS Chem Biol. 2008 Jun 20;3(6):373-82 - PubMed
  73. Sci Rep. 2019 Jan 10;9(1):30 - PubMed
  74. J Photochem Photobiol B. 2009 Jul 17;96(1):1-8 - PubMed
  75. Oncotarget. 2016 Aug 23;7(34):54925-54936 - PubMed
  76. N Engl J Med. 2015 Jan 22;372(4):320-30 - PubMed
  77. Cell Death Dis. 2020 Jun 12;11(6):451 - PubMed
  78. Autophagy. 2014 Aug;10(8):1369-79 - PubMed
  79. PLoS One. 2013 Oct 25;8(10):e78745 - PubMed
  80. Pigment Cell Melanoma Res. 2009 Dec;22(6):740-9 - PubMed
  81. Onco Targets Ther. 2017 Jul 06;10:3313-3327 - PubMed
  82. Bioconjug Chem. 1999 Nov-Dec;10(6):1084-9 - PubMed
  83. Bioconjug Chem. 1997 Jul-Aug;8(4):510-9 - PubMed
  84. Photochem Photobiol Sci. 2002 Jan;1(1):1-21 - PubMed
  85. Photodiagnosis Photodyn Ther. 2012 Jun;9(2):156-63 - PubMed
  86. Oncotarget. 2017 May 23;8(21):35069-35075 - PubMed
  87. Adv Exp Med Biol. 2016;930:133-49 - PubMed
  88. Photodiagnosis Photodyn Ther. 2018 Dec;24:27-35 - PubMed
  89. Photodiagnosis Photodyn Ther. 2018 Dec;24:198-205 - PubMed
  90. J Manag Care Spec Pharm. 2017 Jun;23(6):653-664 - PubMed
  91. Lancet Oncol. 2014 Jun;15(7):e257-67 - PubMed
  92. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5357-63 - PubMed
  93. Biomater Res. 2018 Sep 26;22:25 - PubMed
  94. Clin Cancer Res. 2018 Jul 15;24(14):3377-3385 - PubMed
  95. Br J Cancer. 2009 Dec 15;101(12):2015-22 - PubMed
  96. Bioconjug Chem. 2013 Oct 16;24(10):1674-83 - PubMed
  97. PLoS One. 2012;7(4):e35487 - PubMed
  98. Pharm Res. 2010 May;27(5):811-22 - PubMed
  99. Oncol Res Treat. 2016;39(6):369-76 - PubMed
  100. Nat Biotechnol. 2003 Jan;21(1):86-9 - PubMed
  101. PLoS One. 2014 Feb 06;9(2):e88193 - PubMed
  102. Transfus Med Hemother. 2017 Sep;44(5):303-310 - PubMed
  103. Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3116-3136 - PubMed
  104. J Transl Med. 2014 Sep 23;12:262 - PubMed
  105. Biomaterials. 2017 Apr;122:188-200 - PubMed
  106. Biochim Biophys Acta. 2004 Sep 20;1704(2):59-86 - PubMed
  107. Chem Soc Rev. 2015 Mar 21;44(6):1449-78 - PubMed
  108. Oncotarget. 2016 Mar 22;7(12):14143-52 - PubMed
  109. Oncoimmunology. 2016 Jun 17;5(8):e1201625 - PubMed
  110. J Biol Chem. 2012 Jul 13;287(29):24082-91 - PubMed
  111. Curr Drug Discov Technol. 2014 Mar;11(1):74-84 - PubMed
  112. Acta Biomater. 2017 Apr 15;53:631-642 - PubMed
  113. Photodiagnosis Photodyn Ther. 2017 Sep;19:194-201 - PubMed
  114. Blood. 2014 Nov 20;124(22):3197-200 - PubMed
  115. Onco Targets Ther. 2018 Oct 17;11:7095-7107 - PubMed
  116. Pharmacol Rev. 2015 Oct;67(4):731-53 - PubMed
  117. J Immunother Cancer. 2018 Aug 22;6(1):80 - PubMed
  118. Curr Opin Chem Biol. 2009 Jun;13(3):235-44 - PubMed
  119. Trends Immunol. 2017 Aug;38(8):577-593 - PubMed
  120. FEBS Lett. 2005 Jan 3;579(1):185-90 - PubMed
  121. Bioconjug Chem. 2011 Dec 21;22(12):2487-95 - PubMed
  122. Nat Med. 2011 Nov 06;17(12):1685-91 - PubMed
  123. Photochem Photobiol Sci. 2009 Dec;8(12):1716-23 - PubMed
  124. MAbs. 2014 Jan-Feb;6(1):34-45 - PubMed
  125. NPJ Breast Cancer. 2019 Apr 10;5:13 - PubMed
  126. MAbs. 2019 Feb/Mar;11(2):219-238 - PubMed
  127. Cancers (Basel). 2020 Apr 22;12(4): - PubMed
  128. J Clin Oncol. 2018 Feb 1;36(4):391-398 - PubMed
  129. Int J Mol Sci. 2019 Dec 10;20(24): - PubMed
  130. Biomaterials. 2015 Jun;52:407-16 - PubMed
  131. Planta Med. 2002 Jul;68(7):658-60 - PubMed
  132. Biochem Pharmacol. 2011 Aug 1;82(3):201-9 - PubMed
  133. Bioconjug Chem. 2011 May 18;22(5):825-58 - PubMed
  134. J Neurooncol. 2008 May;87(3):255-61 - PubMed
  135. Laryngoscope. 2000 Aug;110(8):1312-6 - PubMed
  136. Mol Pharm. 2009 Nov-Dec;6(6):1775-89 - PubMed
  137. Lancet. 2009 Mar 21;373(9668):1033-40 - PubMed
  138. Cancer J. 2008 May-Jun;14(3):154-69 - PubMed
  139. J Photochem Photobiol B. 2015 Aug;149:249-56 - PubMed
  140. Int J Biochem Cell Biol. 2017 Jun;87:54-68 - PubMed
  141. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):552-60 - PubMed
  142. Curr Pharm Des. 2013;19(30):5406-13 - PubMed
  143. Front Pharmacol. 2017 Aug 23;8:561 - PubMed
  144. Nature. 1991 Jun 6;351(6326):501-2 - PubMed
  145. Sci Transl Med. 2011 Feb 9;3(69):69ra11 - PubMed
  146. Science. 2014 May 9;344(6184):641-5 - PubMed
  147. Biomol Ther (Seoul). 2015 Nov;23(6):493-509 - PubMed
  148. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24 - PubMed
  149. Front Immunol. 2017 Dec 04;8:1597 - PubMed
  150. Case Rep Oncol. 2018 Nov 27;11(3):769-776 - PubMed
  151. Eur J Surg Oncol. 2012 Apr;38(4):352-60 - PubMed
  152. Nat Rev Cancer. 2012 Dec;12(12):860-75 - PubMed
  153. Int J Biol Sci. 2016 Apr 28;12(6):718-29 - PubMed
  154. PLoS One. 2017 Mar 9;12(3):e0173241 - PubMed
  155. Photochem Photobiol. 1999 Oct;70(4):391-475 - PubMed
  156. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):503-9 - PubMed
  157. Bioconjug Chem. 2015 Aug 19;26(8):1678-86 - PubMed
  158. PLoS One. 2015 Jul 01;10(7):e0131177 - PubMed
  159. J Photochem Photobiol B. 2020 Oct;211:111982 - PubMed
  160. Mol Immunol. 1991 Apr-May;28(4-5):489-98 - PubMed
  161. Int J Dermatol. 2010 Sep;49(9):978-86 - PubMed
  162. Biol Chem. 2013 Feb;394(2):239-50 - PubMed
  163. Photochem Photobiol Sci. 2011 May;10(5):653-63 - PubMed
  164. J Photochem Photobiol B. 2011 May 3;103(2):98-104 - PubMed
  165. Wien Med Wochenschr. 2007;157(13-14):356-61 - PubMed
  166. Eur J Nucl Med Mol Imaging. 2010 Oct;37(10):1926-34 - PubMed
  167. Photochem Photobiol Sci. 2004 Aug;3(8):721-9 - PubMed
  168. Nat Biotechnol. 1996 Jul;14(7):845-51 - PubMed
  169. Melanoma Res. 2018 Jun;28(3):211-221 - PubMed
  170. Cell Biol Int. 2012;36(12):1261-6 - PubMed
  171. Mol Cancer Ther. 2006 Jun;5(6):1474-82 - PubMed
  172. Anticancer Drugs. 2017 Mar;28(3):307-315 - PubMed
  173. Photodiagnosis Photodyn Ther. 2012 Mar;9(1):32-9 - PubMed
  174. Future Oncol. 2017 Mar;13(7):625-636 - PubMed
  175. Neurosurg Focus. 2014 Dec;37(6):E12 - PubMed
  176. Protein Eng. 1996 Oct;9(10):895-904 - PubMed
  177. Oncology (Williston Park). 2009 May;23(6):488-96 - PubMed
  178. Health Sci Rep. 2019 Jan 08;2(2):e103 - PubMed
  179. Clin Cancer Res. 2008 Sep 1;14(17):5610-8 - PubMed
  180. Photochem Photobiol. 1998 Nov;68(5):603-32 - PubMed
  181. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4285-9 - PubMed
  182. Acta Biomater. 2019 Jan 1;83:400-413 - PubMed
  183. Mol Cancer Ther. 2017 Oct;16(10):2201-2214 - PubMed
  184. PLoS One. 2012;7(5):e36762 - PubMed
  185. J Physiol Pharmacol. 2012 Apr;63(2):109-18 - PubMed
  186. Am J Clin Pathol. 2003 Apr;119(4):472-85 - PubMed
  187. Oncoimmunology. 2014 Dec 21;3(11):e970027 - PubMed
  188. Int J Pharm. 2010 Apr 15;389(1-2):32-40 - PubMed
  189. Cancer Immunol Res. 2019 Mar;7(3):401-413 - PubMed
  190. Photodermatol Photoimmunol Photomed. 2004 Feb;20(1):21-6 - PubMed
  191. Clin Cancer Res. 2004 Oct 15;10(20):7063-70 - PubMed
  192. J Surg Res. 2015 Jul;197(1):5-11 - PubMed
  193. Biochem J. 2003 Oct 15;375(Pt 2):449-55 - PubMed
  194. Biochim Biophys Acta. 2016 Apr;1863(4):770-84 - PubMed
  195. PLoS One. 2014 Jul 30;9(7):e103762 - PubMed
  196. PLoS One. 2015 Aug 27;10(8):e0136829 - PubMed
  197. Photochem Photobiol Sci. 2014 Mar;13(3):474-87 - PubMed
  198. Oncol Rep. 2014 Sep;32(3):875-86 - PubMed
  199. Mol Cancer Res. 2017 Sep;15(9):1153-1162 - PubMed
  200. Photochem Photobiol. 2001 Aug;74(2):126-32 - PubMed
  201. Mol Immunol. 1994 Feb;31(3):169-217 - PubMed
  202. Eur Endocrinol. 2020 Apr;16(1):32-39 - PubMed
  203. Clin Cancer Res. 2013 Sep 1;19(17):4868-78 - PubMed
  204. Int J Cancer. 2016 Aug 15;139(4):916-27 - PubMed
  205. BMC Res Notes. 2014 Oct 10;7:710 - PubMed
  206. J Immunol. 1985 Aug;135(2):1530-5 - PubMed
  207. J Clin Invest. 2020 Feb 3;130(2):774-788 - PubMed
  208. Adv Immunol. 2004;84:131-79 - PubMed
  209. Lasers Med Sci. 2001;16(4):276-83 - PubMed
  210. Curr Pharm Des. 2013;19(30):5429-36 - PubMed
  211. Biotechnol Genet Eng Rev. 2013;29:175-86 - PubMed
  212. Nat Nanotechnol. 2009 Nov;4(11):710-1 - PubMed
  213. Cancers (Basel). 2016 Oct 04;8(10): - PubMed
  214. Nat Biotechnol. 2003 Jul;21(7):778-84 - PubMed
  215. Int J Radiat Biol. 2020 Sep;96(9):1087-1103 - PubMed
  216. Nature. 2017 Jan 18;541(7637):321-330 - PubMed
  217. PLoS One. 2012;7(3):e34003 - PubMed
  218. J Natl Cancer Inst. 1988 Mar 2;80(1):56-60 - PubMed
  219. Technol Cancer Res Treat. 2018 Jan 1;17:1533033818791795 - PubMed
  220. Eur J Surg Oncol. 2017 Mar;43(3):604-611 - PubMed
  221. Biomed Res Int. 2017;2017:5407012 - PubMed
  222. N Engl J Med. 2015 Jun 25;372(26):2521-32 - PubMed
  223. Breast Cancer Res Treat. 2015 Aug;153(1):123-33 - PubMed
  224. Cancer Res. 2010 Nov 15;70(22):9319-28 - PubMed
  225. N Engl J Med. 2004 Jul 22;351(4):337-45 - PubMed
  226. CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81 - PubMed
  227. N Engl J Med. 2010 Jul 29;363(5):411-22 - PubMed
  228. Int J Oncol. 2002 Sep;21(3):531-40 - PubMed
  229. Nat Genet. 1997 Feb;15(2):146-56 - PubMed
  230. Clin Cancer Res. 2006 Apr 15;12(8):2568-74 - PubMed
  231. Biochem Pharmacol. 1990 Oct 15;40(8):1859-64 - PubMed
  232. Theranostics. 2016 Oct 23;6(13):2458-2487 - PubMed
  233. Bioconjug Chem. 2020 Jan 15;31(1):28-36 - PubMed
  234. Front Oncol. 2020 May 12;10:597 - PubMed
  235. Anticancer Drugs. 2013 Sep;24(8):835-45 - PubMed
  236. Oncoimmunology. 2017 Nov 27;7(3):e1395996 - PubMed
  237. J Photochem Photobiol B. 2017 Jan;166:18-27 - PubMed
  238. Cancer Res. 2009 Mar 15;69(6):2358-64 - PubMed
  239. Dermatol Surg. 2014 Sep;40(9):948-63 - PubMed
  240. Acta Biochim Pol. 2005;52(2):339-52 - PubMed
  241. Expert Opin Drug Saf. 2017 Dec;16(12):1347-1357 - PubMed
  242. Cancer Treat Rev. 2011 Oct;37(6):465-75 - PubMed
  243. Protein Eng Des Sel. 2006 Jul;19(7):299-307 - PubMed
  244. Clin Exp Vaccine Res. 2014 Jul;3(2):113-6 - PubMed
  245. Annu Rev Med. 2013;64:15-29 - PubMed
  246. Cancer Res. 1985 Feb;45(2):879-85 - PubMed
  247. Oncotarget. 2016 Apr 26;7(17):23361-9 - PubMed
  248. Photodiagnosis Photodyn Ther. 2011 Dec;8(4):297-306 - PubMed
  249. Adv Clin Exp Med. 2012 Mar-Apr;21(2):179-85 - PubMed
  250. J Photochem Photobiol B. 2008 May 29;91(2-3):67-76 - PubMed
  251. Ann Oncol. 2009 Aug;20 Suppl 6:vi1-7 - PubMed
  252. Pharm Res. 2017 Apr;34(4):696-703 - PubMed
  253. N Engl J Med. 2006 Feb 9;354(6):567-78 - PubMed
  254. Drug Resist Updat. 2015 Jan;18:36-46 - PubMed
  255. J Invest Dermatol. 2013 Feb;133(2):289-92 - PubMed
  256. Photodiagnosis Photodyn Ther. 2013 Dec;10(4):591-9 - PubMed
  257. Ther Adv Med Oncol. 2016 Jan;8(1):48-56 - PubMed
  258. Front Immunol. 2019 Mar 19;10:453 - PubMed

Publication Types

Grant support