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Savina IN, Cnudde V, D'Hollander S, et al. Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds. Soft Matter. 2007;3(9):1176-1184doi: 10.1039/b706654f.
Savina, I. N., Cnudde, V., D'Hollander, S., Van Hoorebeke, L., Mattiasson, B., Galaev, I. Y., & Du Prez, F. (2007). Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds. Soft matter, 3(9), 1176-1184. https://doi.org/10.1039/b706654f
Savina, Irina N, et al. "Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds." Soft matter vol. 3,9 (2007): 1176-1184. doi: https://doi.org/10.1039/b706654f
Savina IN, Cnudde V, D'Hollander S, Van Hoorebeke L, Mattiasson B, Galaev IY, Du Prez F. Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds. Soft Matter. 2007 Aug 14;3(9):1176-1184. doi: 10.1039/b706654f. PMID: 32900039.
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Soft Matter. 2007 Aug 14;3(9):1176-1184. doi: 10.1039/b706654f.

Cryogels from poly(2-hydroxyethyl methacrylate): macroporous, interconnected materials with potential as cell scaffolds.

Soft matter

Irina N Savina, Veerle Cnudde, Stijn D'Hollander, Luc Van Hoorebeke, Bo Mattiasson, Igor Yu Galaev, Filip Du Prez

Affiliations

  1. Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, Lund, SE 22 100, Sweden and Protista Biotechnology AB, Ideon, Lund, SE 223 70, Sweden.
  2. Department of Geology and Soil Science, Ghent University, Krijgslaan 281 S8, B-9000 Ghent, Belgium.
  3. Department of Organic Chemistry, Polymer Chemistry Research Group, Ghent University, Krijgslaan 281 S4-bis, B-9000 Ghent, Belgium. [email protected].
  4. Institute for Nuclear Sciences (INW), Proeftuinstraat 86, B-9000 Ghent, Belgium.
  5. Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, Lund, SE 22 100, Sweden.

PMID: 32900039 DOI: 10.1039/b706654f

Abstract

Macroporous hydrogels (MHs) have been prepared by cross-linking polymerization of hydroxyethyl methacrylate (HEMA) or cross-linking co-polymerization of HEMA with dimethylacrylamide (DMAA) in semi-frozen state. The MHs are elastic and have a unique structure of large interconnected pores with pore sizes up to 100 µm and total porosity of 94-97%, as demonstrated by micro-computed tomography. The stiffness of such MHs increased with total monomer concentration and with the ratio of DMAA in the composition. Pore-surface modification of the HEMA MHs was achieved by grafting a stimuli-responsive polymer, poly(-isopropylacrylamide) (PNIPAM), with high density using atom transfer radical polymerization (ATRP). The effect of catalytic system, initiator content and the addition of sacrificial initiator on the ATRP process have been studied. The elasticity, possibility of drying and fast re-swelling, tunable mechanical properties and the macroporous, interconnected structure of HEMA MHs are of interest for biomedical applications such as cell culturing.

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