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Arici C, Benatti B, Cafaro R, et al. A 6-month follow-up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation in patients with major depression. CNS Spectr. 2020;1-6doi: 10.1017/S1092852920001807.
Arici, C., Benatti, B., Cafaro, R., Cremaschi, L., Degoni, L., Pozzoli, S., Oldani, L., Molteni, L., Giorgetti, F., Priori, A., Viganò, C., & Dell'Osso, B. (2020). A 6-month follow-up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation in patients with major depression. CNS spectrums, 1-6. https://doi.org/10.1017/S1092852920001807
Arici, Chiara, et al. "A 6-month follow-up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation in patients with major depression." CNS spectrums vol. (2020): 1-6. doi: https://doi.org/10.1017/S1092852920001807
Arici C, Benatti B, Cafaro R, Cremaschi L, Degoni L, Pozzoli S, Oldani L, Molteni L, Giorgetti F, Priori A, Viganò C, Dell'Osso B. A 6-month follow-up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation in patients with major depression. CNS Spectr. 2020 Sep 04;1-6. doi: 10.1017/S1092852920001807. Epub 2020 Sep 04. PMID: 32883389.
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CNS Spectr. 2020 Sep 04;1-6. doi: 10.1017/S1092852920001807. Epub 2020 Sep 04.

A 6-month follow-up study on response and relapse rates following an acute trial of repetitive transcranial magnetic stimulation in patients with major depression.

CNS spectrums

Chiara Arici, Beatrice Benatti, Rita Cafaro, Laura Cremaschi, Luca Degoni, Sara Pozzoli, Lucio Oldani, Laura Molteni, Federica Giorgetti, Alberto Priori, Caterina Viganò, Bernardo Dell'Osso

Affiliations

  1. Department of Mental Health and Addiction, ASST Vimercate, Vimercate, Italy.
  2. Department of Biomedical and Clinical Sciences 'Luigi Sacco', Department of Mental Health, ASST Fatebenefratelli-Sacco, University of Milan, Milan, Italy.
  3. Department of Health Sciences, 'Aldo Ravelli' Research Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan Medical School, Milan, Italy.
  4. Department of Mental Health and Addiction, ASST Papa Giovanni XXIII, Bergamo, Italy.
  5. Department of Psychiatry, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, Milano, Italy.
  6. Department of Health Sciences, San Paolo Hospital, University of Milan, Milan, Italy.
  7. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.

PMID: 32883389 DOI: 10.1017/S1092852920001807

Abstract

BACKGROUND: Little is known about the post-acute effects of repetitive transcranial magnetic stimulation (rTMS) in patients with major depression. The present study focused on the 6-month follow-up of a sample of patients with major depression, after the completion of an acute 4 weeks rTMS trial, with the aim of evaluating response (in terms of sustained and late response) and relapse rates.

METHODS: Following the completion of an acute trial of rTMS (T0-T4), 31 drug-resistant depressed patients (bipolar or unipolar) entered a naturalistic follow-up period of 6 months, with three timepoints (T5, T6, and T7) during which they were assessed with the Hamilton Depression Rating Scale and the Young Mania Rating Scale.

RESULTS: Results showed that in the 6 months following an acute transcranial magnetic stimulation (TMS) trial, a higher rate of late responders was observed among previously acute TMS nonresponders (63.64%, 7 out of 11) compared to the rate of relapse among those who had acutely responded to TMS (10%, 2 out of 20). In addition, an overall high rate of maintained response (90%) was observed.

CONCLUSION: Present findings seem to support the possibility of obtaining a clinical response also after the end of an acute TMS trial in patients with major depression. The concomitant low rate of relapse observed at the end of follow-up along with a high rate of maintained response provides further support to the post-acute efficacy of TMS. Nonetheless, further controlled studies, with larger samples and longer follow-up observation, are needed to confirm the reported results.

Keywords: Major depression; follow-up; late response; relapse; repetitive TMS (rTMS)

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