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Dees C, Chakraborty D, Distler JHW. Cellular and molecular mechanisms in fibrosis. Exp Dermatol. 2020;30(1):121-131doi: 10.1111/exd.14193.
Dees, C., Chakraborty, D., & Distler, J. H. W. (2021). Cellular and molecular mechanisms in fibrosis. Experimental dermatology, 30(1), 121-131. https://doi.org/10.1111/exd.14193
Dees, Clara, et al. "Cellular and molecular mechanisms in fibrosis." Experimental dermatology vol. 30,1 (2021): 121-131. doi: https://doi.org/10.1111/exd.14193
Dees C, Chakraborty D, Distler JHW. Cellular and molecular mechanisms in fibrosis. Exp Dermatol. 2021 Jan;30(1):121-131. doi: 10.1111/exd.14193. Epub 2020 Oct 09. PMID: 32931037.
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Exp Dermatol. 2021 Jan;30(1):121-131. doi: 10.1111/exd.14193. Epub 2020 Oct 09.

Cellular and molecular mechanisms in fibrosis.

Experimental dermatology

Clara Dees, Debomita Chakraborty, Jörg H W Distler

Affiliations

  1. Friedrich-Alexander-University (FAU) Erlangen-Nürnberg, Department of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany.

PMID: 32931037 DOI: 10.1111/exd.14193

Abstract

The activation of fibroblasts is required for physiological tissue remodelling such as wound healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain persistently activated, the progressive deposition of extracellular matrix proteins leads to tissue fibrosis, which results in dysfunction or even loss of function of the affected organ. Although fibrosis has been recognized as a major cause of morbidity and mortality in modern societies, there are only few treatment options available that directly disrupt the release of extracellular matrix from fibroblasts. Intensive research in recent years, however, identified several pathways as core fibrotic mechanisms that are shared across different fibrotic diseases and organs. We discuss herein selection of those core pathways, especially downstream of the profibrotic TGF-β pathway, which are druggable and which may be transferable from bench to bedside.

© 2020 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.

Keywords: extracellular matrix; fibroblasts; fibrosis; systemic sclerosis

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