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Taher AT, Iolascon A, Matar CF, et al. Recommendations for Pregnancy in Rare Inherited Anemias. Hemasphere. 2020;4(4):e446doi: 10.1097/HS9.0000000000000446.
Taher, A. T., Iolascon, A., Matar, C. F., Bou-Fakhredin, R., de Franceschi, L., Cappellini, M. D., Barcellini, W., Russo, R., Andolfo, I., Tyan, P., Gulbis, B., Aydinok, Y., Anagnou, N. P., Bencaiova, G. A., Tamary, H., Martinez, P. A., Forni, G., & Vindigni, R. (2020). Recommendations for Pregnancy in Rare Inherited Anemias. HemaSphere, 4(4), e446. https://doi.org/10.1097/HS9.0000000000000446
Taher, Ali T, et al. "Recommendations for Pregnancy in Rare Inherited Anemias." HemaSphere vol. 4,4 (2020): e446. doi: https://doi.org/10.1097/HS9.0000000000000446
Taher AT, Iolascon A, Matar CF, Bou-Fakhredin R, de Franceschi L, Cappellini MD, Barcellini W, Russo R, Andolfo I, Tyan P, Gulbis B, Aydinok Y, Anagnou NP, Bencaiova GA, Tamary H, Martinez PA, Forni G, Vindigni R. Recommendations for Pregnancy in Rare Inherited Anemias. Hemasphere. 2020 Aug 12;4(4):e446. doi: 10.1097/HS9.0000000000000446. eCollection 2020 Aug. PMID: 32885142; PMCID: PMC7437563.
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Hemasphere. 2020 Aug 12;4(4):e446. doi: 10.1097/HS9.0000000000000446. eCollection 2020 Aug.

Recommendations for Pregnancy in Rare Inherited Anemias.

HemaSphere

Ali T Taher, Achille Iolascon, Charbel F Matar, Rayan Bou-Fakhredin, Lucia de Franceschi, Maria Domenica Cappellini, Wilma Barcellini, Roberta Russo, Immacolata Andolfo, Paul Tyan, Beatrice Gulbis, Yesim Aydinok, Nicholas P Anagnou, Gabriela Amstad Bencaiova, Hannah Tamary, Patricia Aguilar Martinez, Gianluca Forni, Raffaele Vindigni

Affiliations

  1. Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  2. Department of Molecular Medicine and Medical Biotechnologies, University Federico II of Naples, Italy.
  3. CEINGE Advanced Biotechnologies, Naples, Italy.
  4. Department of Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, AOUI, Verona, Italy.
  5. Department of Clinical Sciences and Community, University of Milan, IRCCS Ca' Granda Foundation Maggiore Policlinico Hospital, Milan, Italy.
  6. Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  7. Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
  8. Departments of Clinical Chemistry and Molecular Genetics, Academic Hospital Erasme, Free University of Brussels, Brussels, Belgium.
  9. Department of Pediatric Hematology and Oncology, Ege University Hospital, Izmir, Turkey.
  10. Cell and Gene Therapy Laboratory, Centre of Basic Research II, Biomedical Research Foundation of The Academy of Athens (BRFAA), Athens, Greece.
  11. Department of Obstetrics and Antenatal Care, University Hospital Basel, Basel, Switzerland.
  12. Department of Pediatric Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
  13. Department of biological hematology, CHU de Montpellier, and Montpellier University, Montpellier, France.
  14. Centro della Microcitemia e delle Anemie Congenite, Ospedale Galliera, Genova, Italy.
  15. United Onlus - Federazione Italiana delle Thalassemie, Emoglobinopatie Rare e Drepanocitosi, Ferrara, Italy.

PMID: 32885142 PMCID: PMC7437563 DOI: 10.1097/HS9.0000000000000446

Abstract

Rare inherited anemias are a subset of anemias caused by a genetic defect along one of the several stages of erythropoiesis or in different cellular components that affect red blood cell integrity, and thus its lifespan. Due to their low prevalence, several complications on growth and development, and multi-organ system damage are not yet well defined. Moreover, during the last decade there has been a lack of proper understanding of the impact of rare anemias on maternal and fetal outcomes. In addition, there are no clear-cut guidelines outlining the pathophysiological trends and management options unique to this special population. Here, we present on behalf of the European Hematology Association, evidence- and consensus-based guidelines, established by an international group of experts in different fields, including hematologists, gynecologists, general practitioners, medical geneticists, and experts in rare inherited anemias from various European countries for standardized and appropriate choice of therapeutic interventions for the management of pregnancy in rare inherited anemias, including Diamond-Blackfan Anemia, Congenital Dyserythropoietic Anemias, Thalassemia, Sickle Cell Disease, Enzyme deficiency and Red cell membrane disorders.

Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

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