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Hennessen F, Miethke M, Zaburannyi N, et al. Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin. Antibiotics (Basel). 2020;9(9)doi: 10.3390/antibiotics9090619.
Hennessen, F., Miethke, M., Zaburannyi, N., Loose, M., Lukežič, T., Bernecker, S., Hüttel, S., Jansen, R., Schmiedel, J., Fritzenwanker, M., Imirzalioglu, C., Vogel, J., Westermann, A. J., Hesterkamp, T., Stadler, M., Wagenlehner, F., Petković, H., Herrmann, J., & Müller, R. (2020). Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin. Antibiotics (Basel, Switzerland), 9(9), . https://doi.org/10.3390/antibiotics9090619
Hennessen, Fabienne, et al. "Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin." Antibiotics (Basel, Switzerland) vol. 9,9 (2020). doi: https://doi.org/10.3390/antibiotics9090619
Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežič T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, Imirzalioglu C, Vogel J, Westermann AJ, Hesterkamp T, Stadler M, Wagenlehner F, Petković H, Herrmann J, Müller R. Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin. Antibiotics (Basel). 2020 Sep 18;9(9). doi: 10.3390/antibiotics9090619. PMID: 32962088; PMCID: PMC7559539.
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Antibiotics (Basel). 2020 Sep 18;9(9). doi: 10.3390/antibiotics9090619.

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.

Antibiotics (Basel, Switzerland)

Fabienne Hennessen, Marcus Miethke, Nestor Zaburannyi, Maria Loose, Tadeja Lukežič, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Judith Schmiedel, Moritz Fritzenwanker, Can Imirzalioglu, Jörg Vogel, Alexander J Westermann, Thomas Hesterkamp, Marc Stadler, Florian Wagenlehner, Hrvoje Petković, Jennifer Herrmann, Rolf Müller

Affiliations

  1. Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, 66123 Saarbrücken, Germany.
  2. German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany.
  3. Clinic for Urology, Paediatric Urology & Andrology, Justus-Liebig University Gießen, and German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35392 Gießen, Germany.
  4. National Institute of Biology, Ve?na pot 111, 1000 Ljubljana, Slovenia.
  5. Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
  6. Institute of Medical Microbiology, Justus-Liebig University Gießen, and German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, 35390 Gießen, Germany.
  7. Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI) and Institute of Molecular Infection Biology (IMIB), University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
  8. Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.

PMID: 32962088 PMCID: PMC7559539 DOI: 10.3390/antibiotics9090619

Abstract

The reassessment of known but neglected natural compounds is a vital strategy for providing novel lead structures urgently needed to overcome antimicrobial resistance. Scaffolds with resistance-breaking properties represent the most promising candidates for a successful translation into future therapeutics. Our study focuses on chelocardin, a member of the atypical tetracyclines, and its bioengineered derivative amidochelocardin, both showing broad-spectrum antibacterial activity within the ESKAPE (

Keywords: AcrAB-TolC efflux pump; atypical tetracyclines; broad-spectrum antibiotics; chelocardins; clinical isolates; mechanism of resistance; resistance-breaking properties; urinary tract infection (UTI); uropathogens

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