Display options
Cite
Xie J, Guo J, Kanwal Z, et al. Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. Int J Endocrinol. 2020;2020:3236828doi: 10.1155/2020/3236828.
Xie, J., Guo, J., Kanwal, Z., Wu, M., Lv, X., Ibrahim, N. A., Li, P., Buabeid, M. A., Arafa, E. A., & Sun, Q. (2020). Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. International journal of endocrinology, 20203236828. https://doi.org/10.1155/2020/3236828
Xie, Jingbo, et al. "Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations." International journal of endocrinology vol. 2020 (2020): 3236828. doi: https://doi.org/10.1155/2020/3236828
Xie J, Guo J, Kanwal Z, Wu M, Lv X, Ibrahim NA, Li P, Buabeid MA, Arafa EA, Sun Q. Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. Int J Endocrinol. 2020 Sep 10;2020:3236828. doi: 10.1155/2020/3236828. eCollection 2020. PMID: 32963524; PMCID: PMC7501564.
Copy Download .nbib Format: NLM
Share it on

Int J Endocrinol. 2020 Sep 10;2020:3236828. doi: 10.1155/2020/3236828. eCollection 2020.

Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations.

International journal of endocrinology

Jingbo Xie, Jian Guo, Zaeema Kanwal, Mingzheng Wu, Xiangyang Lv, Nihal Abdalla Ibrahim, Ping Li, Manal Ali Buabeid, El-Shaimaa A Arafa, Qingshan Sun

Affiliations

  1. Department of Orthopedics, Fengcheng People's Hospital, Fengcheng, Jiangxi 331100, China.
  2. Department of the Second Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Traditional Chinese Medicine, Nanchang Hongdu Traditional Chinese Medicine Hospital, Nanchang, Jiangxi 330008, China.
  3. Ameer Ud Din Medical College, Lahore, Pakistan.
  4. Department of Orthopaedics, Pu'ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
  5. Department of Orthopaedics, Xi'an International Medical Center Hospital, Xi'an, Shaanxi 710100, China.
  6. Department of Clinical Sciences, Ajman University, Ajman 346, UAE.
  7. Department of Orthopaedics, Ya'an People's Hospital, Ya'an, Sichuan 625000, China.
  8. Department of Orthopedics, The Third Hospital of Shandong Province, Jinan, Shandong 250031, China.

PMID: 32963524 PMCID: PMC7501564 DOI: 10.1155/2020/3236828

Abstract

Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release from the bone. Thus, calcitonin was said as a primary regulator of the bone resorption process. This is the reason why calcitonin has been used widely in clinics for the treatment of bone disorders such as osteoporosis, hypercalcemia, and Paget's disease. However, presently calcitonin usage is declined due to the development of efficacious formulations of new drugs. Calcitonin gene-related peptides and several other peptides such as intermedin, amylin, and adrenomedullin (ADM) are categorized in calcitonin family. These peptides are known for the structural similarity with calcitonin. Aside from having a similar structure, these peptides have few overlapping biological activities and signal transduction action through related receptors. However, several other activities are also present that are peptide specific.

Copyright © 2020 Jingbo Xie et al.

Conflict of interest statement

The authors declare that there are no conflicts of interest in our manuscript.

References

  1. Crit Rev Biochem Mol Biol. 2016;51(1):65-71 - PubMed
  2. Peptides. 2002 Dec;23(12):2163-8 - PubMed
  3. J Clin Invest. 2002 Dec;110(12):1849-57 - PubMed
  4. Biochem Biophys Res Commun. 2004 May 21;318(1):240-6 - PubMed
  5. Peptides. 1997;18(4):537-40 - PubMed
  6. J Bone Miner Res. 2008 Aug;23(8):1182-93 - PubMed
  7. Bone. 2002 Sep;31(3):359-65 - PubMed
  8. Clin Endocrinol (Oxf). 2008 Jun;68(6):890-7 - PubMed
  9. Mol Cell. 2015 Jun 18;58(6):1040-52 - PubMed
  10. Endocrinology. 1966 Sep;79(3):655-8 - PubMed
  11. Biochem Biophys Res Commun. 1993 Apr 30;192(2):553-60 - PubMed
  12. Biochem Biophys Res Commun. 1989 Jul 31;162(2):876-81 - PubMed
  13. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19279-84 - PubMed
  14. J Clin Invest. 1981 Sep;68(3):815-8 - PubMed
  15. J Bone Miner Res. 2015 Feb;30(2):212-5 - PubMed
  16. Nature. 1981 Mar 5;290(5801):63-5 - PubMed
  17. J Cell Biol. 2004 Feb 16;164(4):509-14 - PubMed
  18. J Endocrinol. 2007 Dec;195(3):415-27 - PubMed
  19. Lancet. 1989 Oct 28;2(8670):1026-7 - PubMed
  20. J Biol Chem. 2007 Jun 22;282(25):18094-9 - PubMed
  21. Am J Physiol. 1999 Nov;277(5):E779-83 - PubMed
  22. Growth Factors. 2004 Dec;22(4):217-24 - PubMed
  23. Mol Endocrinol. 1993 Jun;7(6):815-21 - PubMed
  24. Mol Endocrinol. 2011 Jul;25(7):1244-53 - PubMed
  25. Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E627-33 - PubMed
  26. Am J Physiol. 1997 Dec;273(6):E1113-20 - PubMed
  27. Life Sci. 1984 Jun 11;34(24):2393-8 - PubMed
  28. Endocrinology. 1965 Jan;76:103-7 - PubMed
  29. Osteoporos Int. 2008 Apr;19(4):479-91 - PubMed
  30. Connect Tissue Res. 2013;54(2):139-46 - PubMed
  31. Exp Clin Endocrinol Diabetes. 1995;103(6):345-51 - PubMed
  32. J Endocrinol. 1993 Jan;136(1):7-15 - PubMed
  33. N Engl J Med. 2016 Oct 20;375(16):1532-1543 - PubMed
  34. Am J Med. 2000 Sep;109(4):267-76 - PubMed
  35. Bone. 1993 Mar-Apr;14(2):167-72 - PubMed
  36. Endocrinology. 2001 May;142(5):1849-57 - PubMed
  37. Bone. 2002 May;30(5):655-63 - PubMed
  38. Rheumatol Int. 2009 Aug;29(10):1161-8 - PubMed
  39. Endocrinology. 1996 Mar;137(3):1042-8 - PubMed
  40. Am J Physiol Cell Physiol. 2004 Aug;287(2):C457-67 - PubMed
  41. Ann Pharmacother. 2013 Dec;47(12):1675-84 - PubMed
  42. Arch Biochem Biophys. 2008 May 15;473(2):210-7 - PubMed
  43. Eur J Clin Microbiol Infect Dis. 2013 Jun;32(6):807-14 - PubMed
  44. J Pharmacol Toxicol Methods. 1999 Dec;42(4):217-24 - PubMed
  45. J Bone Miner Res. 1986 Feb;1(1):51-6 - PubMed
  46. J Clin Pharmacol. 2011 Apr;51(4):460-71 - PubMed
  47. Nature. 1998 May 28;393(6683):333-9 - PubMed
  48. Cytokine. 1999 Mar;11(3):200-7 - PubMed
  49. Am J Physiol. 1998 Oct;275(4):E694-9 - PubMed
  50. J Clin Invest. 1999 Nov;104(10):1363-74 - PubMed
  51. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5064-7 - PubMed
  52. J Bone Miner Res. 1999 Aug;14(8):1302-9 - PubMed
  53. Br J Pharmacol. 2012 May;166(1):110-20 - PubMed
  54. J Clin Pathol. 2015 Sep;68(9):675-9 - PubMed
  55. Br Med Bull. 2013;105:185-99 - PubMed
  56. PLoS One. 2014 Mar 18;9(3):e92042 - PubMed
  57. Br Med J (Clin Res Ed). 1984 Mar 17;288(6420):812-3 - PubMed
  58. Am J Med. 1983 Mar;74(3):421-32 - PubMed
  59. Biochem J. 1988 Oct 15;255(2):377-90 - PubMed
  60. Mol Med Rep. 2016 Jun;13(6):4689-96 - PubMed
  61. Diabetologia. 1991 Feb;34(2):129-32 - PubMed
  62. Oncotarget. 2017 Mar 8;8(39):66504-66515 - PubMed
  63. J Biol Chem. 2003 Apr 4;278(14):12046-54 - PubMed
  64. Osteoarthritis Cartilage. 2008 Apr;16(4):450-7 - PubMed
  65. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3881-5 - PubMed
  66. J Bone Miner Res. 1992 Sep;7(9):1113-6 - PubMed
  67. Clin Exp Rheumatol. 1985 Apr-Jun;3(2):155-7 - PubMed
  68. Osteoporos Int. 1997;7(3):165-74 - PubMed
  69. J Bone Miner Res. 1989 Apr;4(2):269-72 - PubMed
  70. J Bone Miner Metab. 2017 Sep;35(5):544-553 - PubMed
  71. Microsc Res Tech. 2002 Apr 1;57(1):1-2 - PubMed
  72. Arthritis Rheum. 2007 Aug;56(8):2674-8 - PubMed
  73. J Bone Miner Res. 1991 Oct;6(10):1137-42 - PubMed
  74. Endocrinology. 2001 Dec;142(12):5050-5 - PubMed
  75. Mol Cell Endocrinol. 2013 Jan 30;365(2):309-15 - PubMed
  76. Bone. 2010 May;46(5):1369-79 - PubMed
  77. Diabetes. 1990 Jun;39(6):752-6 - PubMed
  78. J Cell Physiol. 2010 Nov;225(3):701-8 - PubMed
  79. Bone. 2008 Nov;43(5):813-8 - PubMed
  80. Endocrinology. 1966 Dec;79(6):1033-9 - PubMed
  81. Osteoarthritis Cartilage. 2006 Aug;14(8):759-68 - PubMed
  82. PLoS One. 2014 Jul 10;9(7):e102356 - PubMed
  83. Bone. 2010 Jun;46(6):1486-97 - PubMed
  84. N Engl J Med. 1987 Aug 27;317(9):537-41 - PubMed
  85. Peptides. 2004 Nov;25(11):2027-38 - PubMed
  86. Nature. 1978 Feb 9;271(5645):501 - PubMed
  87. Proc Natl Acad Sci U S A. 1969 Oct;64(2):771-8 - PubMed
  88. J Bone Miner Res. 1999 Jul;14(7):1067-74 - PubMed
  89. Neuron. 1993 Dec;11(6):1187-95 - PubMed
  90. Experientia. 1976 Sep 15;32(9):1104-6 - PubMed
  91. Neuropeptides. 1984 Sep;4(5):425-34 - PubMed
  92. FEBS J. 2006 Aug;273(15):3614-24 - PubMed
  93. Eur J Pharmacol. 2000 Dec 15;409(3):273-8 - PubMed
  94. J Clin Invest. 1995 Jan;95(1):167-71 - PubMed
  95. Science. 1964 Oct 16;146(3642):412-3 - PubMed
  96. Exp Physiol. 1990 Jul;75(4):529-36 - PubMed
  97. Curr Pharm Des. 2002;8(23):2009-21 - PubMed
  98. Endocrinology. 2008 Nov;149(11):5423-31 - PubMed
  99. Nature. 1962 Jan 27;193:381-2 - PubMed
  100. J Endocrinol. 2014 Apr 22;221(2):181-91 - PubMed
  101. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):615-9 - PubMed
  102. J Endocrinol. 2001 Jul;170(1):251-7 - PubMed
  103. Pharmacol Rev. 2002 Jun;54(2):233-46 - PubMed
  104. Diabetes. 1992 Apr;41(4):508-14 - PubMed
  105. J Endocrinol. 1992 Jul;134(1):141-7 - PubMed
  106. Trans Assoc Am Physicians. 1991;104:265-72 - PubMed
  107. J Endocrinol. 2000 Jun;165(3):663-8 - PubMed
  108. Calcif Tissue Int. 1986 Jun;38(6):339-41 - PubMed
  109. Kidney Int. 1991 Aug;40(2):219-25 - PubMed
  110. Nature. 1968 Dec 7;220(5171):984-6 - PubMed
  111. Endocrinology. 1986 Jan;118(1):46-51 - PubMed
  112. Am J Med. 2000 Sep;109(4):330-1 - PubMed
  113. Arthritis Rheum. 2012 Apr;64(4):1069-81 - PubMed
  114. J Bone Miner Res. 2005 Sep;20(9):1548-61 - PubMed
  115. Endocrinology. 1972 Mar;90(3):752-9 - PubMed
  116. Rheumatology (Oxford). 2004 Aug;43(8):955-9 - PubMed
  117. J Biol Chem. 2005 Mar 11;280(10):9297-307 - PubMed
  118. BMC Musculoskelet Disord. 2011 Aug 15;12:186 - PubMed
  119. Bone. 2015 Mar;72:34-42 - PubMed
  120. J Bone Miner Res. 2001 May;16(5):958-65 - PubMed
  121. Bone. 2007 May;40(5):1329-42 - PubMed
  122. Peptides. 2000 Apr;21(4):559-64 - PubMed
  123. Calcif Tissue Int. 2006 Jun;78(6):398-403 - PubMed
  124. J Bone Miner Res. 1992 Sep;7(9):1011-9 - PubMed
  125. J Clin Invest. 1995 Jun;95(6):2680-91 - PubMed
  126. Nature. 1983 Jul 14-20;304(5922):129-35 - PubMed
  127. J Orthop Surg Res. 2010 Nov 04;5:83 - PubMed
  128. Bone. 1997 Sep;21(3):269-74 - PubMed
  129. Annu Rev Pharmacol Toxicol. 2016;56:469-87 - PubMed
  130. J Cell Physiol. 2008 Apr;215(1):122-8 - PubMed
  131. PLoS One. 2014 Dec 23;9(12):e113959 - PubMed
  132. Genes Dev. 1996 Jan 15;10(2):208-19 - PubMed
  133. J Intensive Care. 2017 Aug 3;5:51 - PubMed
  134. Br J Pharmacol. 2012 May;166(1):51-65 - PubMed
  135. Expert Opin Drug Metab Toxicol. 2016 Jun;12(6):681-9 - PubMed
  136. Crit Rev Neurobiol. 1997;11(2-3):167-239 - PubMed
  137. Endocrine. 2003 Aug;21(3):201-8 - PubMed
  138. J Bone Miner Res. 1996 Apr;11(4):456-65 - PubMed
  139. J Bone Miner Res. 1997 Dec;12(12):2014-23 - PubMed
  140. Bone. 1996 Jun;18(6):629-32 - PubMed
  141. Bone. 1995 Apr;16(4 Suppl):379S-384S - PubMed
  142. BMJ. 1992 Nov 7;305(6862):1124-8 - PubMed
  143. J Cell Biochem. 2008 Jun 1;104(3):920-33 - PubMed
  144. Biochem Biophys Res Commun. 1991 Aug 30;179(1):134-9 - PubMed
  145. Calcif Tissue Int. 2010 Mar;86(3):249-60 - PubMed
  146. Exp Ther Med. 2017 Nov;14(5):4001-4008 - PubMed
  147. BMC Clin Pharmacol. 2008 Sep 09;8:5 - PubMed
  148. Endocrinology. 2015 Sep;156(9):3203-14 - PubMed
  149. Clin Sci (Lond). 1993 Oct;85(4):385-8 - PubMed
  150. J Bone Miner Res. 2013 May;28(5):973-9 - PubMed
  151. Pharmacol Ther. 2006 Jan;109(1-2):173-97 - PubMed
  152. J Biol Chem. 2004 Feb 20;279(8):7264-74 - PubMed
  153. Endocrine. 2016 Jun;52(3):414-26 - PubMed
  154. Regul Pept. 1993 Nov 19;49(1):65-72 - PubMed
  155. J Biol Chem. 1959 Dec;234:3179-81 - PubMed
  156. Science. 1965 Dec 10;150(3702):1465-7 - PubMed
  157. J Cell Biochem. 2011 Nov;112(11):3300-12 - PubMed
  158. Biochem Biophys Res Commun. 1995 Feb 6;207(1):133-9 - PubMed
  159. Acta Pharmacol Sin. 2013 Nov;34(11):1467-74 - PubMed
  160. Microsc Res Tech. 2002 Apr 1;57(1):55-9 - PubMed
  161. Exp Physiol. 1993 Mar;78(2):183-96 - PubMed
  162. J Endocrinol. 2005 Dec;187(3):311-25 - PubMed
  163. Am J Physiol. 1998 May;274(5):E827-33 - PubMed
  164. Endocrinology. 2006 Sep;147(9):4010-21 - PubMed
  165. Clin Orthop. 1957;9:46-60 - PubMed
  166. Clin Sci (Lond). 1991 Dec;81(6):803-8 - PubMed
  167. J Bone Miner Res. 2006 Dec;21(12):1924-34 - PubMed
  168. Hum Genet. 1985;70(3):259-63 - PubMed
  169. Nat Commun. 2014 Oct 21;5:5215 - PubMed
  170. Mol Pharmacol. 1994 Aug;46(2):246-55 - PubMed
  171. J Pathol. 1982 Jan;136(1):27-39 - PubMed
  172. Bone. 2001 Aug;29(2):162-8 - PubMed
  173. J Cell Biochem. 2011 Dec;112(12):3807-15 - PubMed
  174. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16702-7 - PubMed
  175. Endocrinology. 1995 Dec;136(12):5377-84 - PubMed
  176. Bone. 1999 Jul;25(1):1-8 - PubMed
  177. Cell. 2016 Oct 20;167(3):739-749.e11 - PubMed
  178. Mol Pharmacol. 1999 Jul;56(1):235-42 - PubMed
  179. Calcif Tissue Int. 1986 Jul;39(1):44-8 - PubMed
  180. J Bone Miner Res. 2012 May;27(5):1018-29 - PubMed
  181. Bull Tokyo Dent Coll. 2012;53(4):203-6 - PubMed
  182. J Endocrinol. 1990 Sep;126(3):473-81 - PubMed
  183. Peptides. 2009 Sep;30(9):1753-62 - PubMed
  184. Diabetes. 1990 May;39(5):639-42 - PubMed
  185. Peptides. 1997;18(9):1461-3 - PubMed
  186. Osteoarthritis Cartilage. 2012 Feb;20(2):136-43 - PubMed
  187. Am J Physiol Endocrinol Metab. 2000 Oct;279(4):E730-5 - PubMed
  188. Biochem Biophys Res Commun. 1995 Jan 5;206(1):341-7 - PubMed
  189. Adv Pharmacol. 2005;52:19-45 - PubMed
  190. J Endocrinol. 2000 Jul;166(1):213-26 - PubMed
  191. Bioorg Med Chem. 2012 Oct 15;20(20):6011-8 - PubMed
  192. Mol Med Rep. 2015 Nov;12(5):6711-7 - PubMed
  193. Diabetologia. 1991 Jan;34(1):52-4 - PubMed
  194. Bone. 2011 Feb;48(2):354-61 - PubMed
  195. FEBS Lett. 2004 Jan 2;556(1-3):53-8 - PubMed
  196. Endocrinology. 1999 Jun;140(6):2924-7 - PubMed
  197. Mol Cell Biochem. 2015 Apr;402(1-2):101-10 - PubMed
  198. J Endocrinol. 1984 Sep;102(3):281-6 - PubMed
  199. Lancet. 1966 Apr 23;1(7443):900-2 - PubMed
  200. Endocrinology. 1962 May;70:638-49 - PubMed
  201. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8628-32 - PubMed
  202. Calcif Tissue Int. 1995 Jan;56(1):54-61 - PubMed
  203. Science. 1985 Sep 13;229(4718):1094-7 - PubMed
  204. J Clin Invest. 2008 Jan;118(1):40-50 - PubMed
  205. Bioorg Med Chem. 2012 Apr 15;20(8):2661-8 - PubMed
  206. FASEB J. 2014 Mar;28(3):1237-47 - PubMed
  207. Bone. 1995 Nov;17(5):447-53 - PubMed
  208. Biochem Biophys Res Commun. 2004 Sep 3;321(4):802-8 - PubMed
  209. Diabetes. 1991 Dec;40(12):1701-6 - PubMed
  210. J Biol Chem. 2016 Oct 14;291(42):21925-21944 - PubMed
  211. Endocrinology. 2006 Sep;147(9):4007-9 - PubMed
  212. J Cell Physiol. 1992 Oct;153(1):6-14 - PubMed
  213. Br J Pharmacol. 2016 Jun;173(12):1883-98 - PubMed
  214. J Bone Miner Res. 2004 Dec;19(12):2049-56 - PubMed
  215. Physiol Rev. 2011 Jul;91(3):795-826 - PubMed
  216. Cell Biochem Biophys. 2015 Dec;73(3):609-17 - PubMed
  217. Am J Pathol. 2007 Mar;170(3):1018-27 - PubMed
  218. Bone. 2016 Oct;91:122-9 - PubMed
  219. Front Physiol. 2016 Jun 30;7:280 - PubMed
  220. Lancet. 1988 Apr 23;1(8591):900-2 - PubMed
  221. Bone. 2017 Mar;96:29-37 - PubMed
  222. Adv Exp Med Biol. 2012;744:49-60 - PubMed
  223. N Engl J Med. 2017 Oct 12;377(15):1417-1427 - PubMed
  224. Endocrinology. 1988 Jul;123(1):159-67 - PubMed
  225. Curr Protein Pept Sci. 2013 Aug;14(5):347-57 - PubMed

Publication Types