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Parra F, Kormanovski A, Guevara-Balcazar G, et al. Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium. J Ophthalmol. 2020;2020:9638763doi: 10.1155/2020/9638763.
Parra, F., Kormanovski, A., Guevara-Balcazar, G., Castillo-Hernández, M. D. C., Franco-Vadillo, A., Toledo-Blas, M., Jarillo-Luna, R. A., & Lara-Padilla, E. (2020). Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium. Journal of ophthalmology, 20209638763. https://doi.org/10.1155/2020/9638763
Parra, Fidelina, et al. "Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium." Journal of ophthalmology vol. 2020 (2020): 9638763. doi: https://doi.org/10.1155/2020/9638763
Parra F, Kormanovski A, Guevara-Balcazar G, Castillo-Hernández MDC, Franco-Vadillo A, Toledo-Blas M, Jarillo-Luna RA, Lara-Padilla E. Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium. J Ophthalmol. 2020 Aug 29;2020:9638763. doi: 10.1155/2020/9638763. eCollection 2020. PMID: 32908689; PMCID: PMC7477589.
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J Ophthalmol. 2020 Aug 29;2020:9638763. doi: 10.1155/2020/9638763. eCollection 2020.

Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium.

Journal of ophthalmology

Fidelina Parra, Alexander Kormanovski, Gustavo Guevara-Balcazar, María Del Carmen Castillo-Hernández, Antonio Franco-Vadillo, Mireille Toledo-Blas, Rosa Adriana Jarillo-Luna, Eleazar Lara-Padilla

Affiliations

  1. Departamento de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.

PMID: 32908689 PMCID: PMC7477589 DOI: 10.1155/2020/9638763

Abstract

OBJECTIVE: In the pathogenesis of pterygium, the protective role of glutathione and nitric oxide production is unclear. These are important factors for homeostasis in the redox state of cells. The aim of this study was to determine the levels of these and related parameters in pterygium tissue.

RESULTS: Compared with the control, decreased levels of eNOS, NO, and 3-nitrotyrosine as well as the degree of oxidation of GSH (GSSG%) were observed in primary and recurrent pterygium. 3-Nitrotyrosine and GSSG% were reduced in the other pterygium groups. GSH and CAT were enhanced in recurrent pterygium and systemic-treated primary pterygium but were unchanged for topical-treated primary pterygium. There was a strong positive correlation of eNOS with NO and 3NT, GSSG% with NO and 3NT, and GSH with GSSG and CAT. Women showed a higher level of GSH and catalase in primary pterygium, whereas a lower level of GSH and a higher level of NO in recurrent pterygium.

CONCLUSION: The results are congruent with the following proposed sequence of events leading to a protective response of the organism during the pathogenesis of primary pterygium: a decreased level of eNOS provokes a decline in the level of NO in pterygium tissue, which then leads to reduced S-nitrosylation of GSH or other thiols and possibly to the modulation of the intracellular level of GSH through synthesis and/or mobilization from other tissues.

Copyright © 2020 Fidelina Parra et al.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

  1. Cardiovasc Diabetol. 2011 May 21;10:43 - PubMed
  2. Mutat Res. 2013 Apr-Jun;752(2):153-71 - PubMed
  3. Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3130-4 - PubMed
  4. J Biol Chem. 1994 Aug 5;269(31):19731-7 - PubMed
  5. Ocul Surf. 2008 Jan;6(1):24-43 - PubMed
  6. Oncol Lett. 2012 Dec;4(6):1247-1253 - PubMed
  7. Free Radic Biol Med. 2006 Dec 15;41(12):1817-28 - PubMed
  8. Am J Physiol. 1998 Jul;275(1):C323-6 - PubMed
  9. Am J Ophthalmol. 1960 Oct;50:635-44 - PubMed
  10. Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1202-10 - PubMed
  11. Nitric Oxide. 2014 Nov 15;42:9-18 - PubMed
  12. J Am Coll Nutr. 1986;5(2):137-51 - PubMed
  13. Am J Physiol. 1999 Jul;277(1):L113-8 - PubMed
  14. Colloids Surf B Biointerfaces. 2015 Jun 1;130:182-91 - PubMed
  15. Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1154-61 - PubMed
  16. J Ocul Pharmacol Ther. 2010 Aug;26(4):329-33 - PubMed
  17. BMC Ophthalmol. 2014 Nov 27;14:149 - PubMed
  18. Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:49-56 - PubMed
  19. FASEB J. 1999 Oct;13(13):1845-54 - PubMed
  20. Int J Chron Obstruct Pulmon Dis. 2006;1(4):425-34 - PubMed
  21. Curr Opin Ophthalmol. 1999 Aug;10(4):282-8 - PubMed
  22. Exp Eye Res. 2000 Feb;70(2):215-20 - PubMed
  23. Can J Physiol Pharmacol. 2006 Nov;84(11):1223-7 - PubMed
  24. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):47-54 - PubMed
  25. Can J Ophthalmol. 2005 Dec;40(6):743-6 - PubMed
  26. Vestn Oftalmol. 2017;133(5):76-83 - PubMed
  27. Ocul Surf. 2007 Oct;5(4):269-79 - PubMed

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