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Glob Health Action. 2019 Dec 13;12:1815272. doi: 10.1080/16549716.2020.1815272.

Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal .

Global health action

Nana Adoma Nkansa-Gyamfi, Joseph Kazibwe, Daouda A K Traore, Emmanuel Nji

Affiliations

  1. BioStruct-Africa , VĂ„rby, Sweden.
  2. Department of Infectious Disease Epidemiology, Imperial College London , London, UK.
  3. Faculte ? Des Sciences Et Techniques, Universite ? Des Sciences, Des Techniques Et Des Technologies De Bamako (USTTB) , Bamako, Mali.
  4. Life Sciences Group, Institut Laue- Langevin , Grenoble, France.
  5. School of Life Sciences, Faculty of Natural Sciences, Keele University , Staffordshire, UK.

PMID: 32909519 PMCID: PMC7782630 DOI: 10.1080/16549716.2020.1815272

Abstract

BACKGROUND: The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings. Relatively few studies have been conducted in community settings, but these have consistently shown a high prevalence of multidrug-resistant bacteria in low- and middle-income countries (LMICs).

OBJECTIVES: To provide an appraisal of the evidence on the high prevalence of multidrug-, extensive drug-, and pandrug-resistance in commensal

METHODS: Using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, PubMed, EMBASE, MEDLINE, Web of Science, CINAHL, and Cochrane Library databases were systematically searched with the search string: 'Enterobacteriaceae', OR '

RESULTS: The prevalence of multidrug-, extensive drug- and pandrug-resistance were extracted from articles that met our inclusion criteria and pooled together after a systematic screening of 9,369 items. The prevalence of multidrug-resistance was 28% of 14,336 total cases of isolates tested, 95% CI: 23-32. Extensive drug-resistance was 24% of 8,686 total cases of isolates tested, 95% CI: 14-36. Lastly, pandrug-resistance was 5% of 5,670 total cases of isolates tested, 95% CI: 3-8.

CONCLUSION: This paper provides an appraisal of the evidence on the high prevalence of multidrug-, extensive drug- and pandrug-resistance by commensal

Keywords: Antibiotic resistance; Antimicrobial Resistance; commensal Escherichia coli; community settings; health policy; multidrug resistance

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