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Vrigkou E, Tsantes AE, Kopterides P, et al. Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction. Diagnostics (Basel). 2020;10(10)doi: 10.3390/diagnostics10100758.
Vrigkou, E., Tsantes, A. E., Kopterides, P., Orfanos, S. E., Armaganidis, A., Maratou, E., Rapti, E., Pappas, A., Tsantes, A. G., & Tsangaris, I. (2020). Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction. Diagnostics (Basel, Switzerland), 10(10), . https://doi.org/10.3390/diagnostics10100758
Vrigkou, Eleni, et al. "Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction." Diagnostics (Basel, Switzerland) vol. 10,10 (2020). doi: https://doi.org/10.3390/diagnostics10100758
Vrigkou E, Tsantes AE, Kopterides P, Orfanos SE, Armaganidis A, Maratou E, Rapti E, Pappas A, Tsantes AG, Tsangaris I. Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction. Diagnostics (Basel). 2020 Sep 27;10(10). doi: 10.3390/diagnostics10100758. PMID: 32992591; PMCID: PMC7601126.
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Diagnostics (Basel). 2020 Sep 27;10(10). doi: 10.3390/diagnostics10100758.

Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction.

Diagnostics (Basel, Switzerland)

Eleni Vrigkou, Argyrios E Tsantes, Petros Kopterides, Stylianos E Orfanos, Apostolos Armaganidis, Eirini Maratou, Evdoxia Rapti, Athanasios Pappas, Andreas G Tsantes, Iraklis Tsangaris

Affiliations

  1. Second Department of Critical Care Medicine, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, 12462 Athens, Greece.
  2. Laboratory of Hematology and Blood Bank Unit, "Attikon" University Hospital, Medical School, National and Kapodistrian University of Athens, Rimini 1, 12462 Athens, Greece.
  3. Laboratory of Clinical Biochemistry, "Attikon" University Hospital, Medical School, University of Athens, Rimini 1, 12462 Athens, Greece.

PMID: 32992591 PMCID: PMC7601126 DOI: 10.3390/diagnostics10100758

Abstract

Many pathophysiologic processes of pulmonary arterial hypertension (PAH), namely, excess vasoconstriction, vascular remodeling and in situ thrombosis, involve the coagulation cascade, and more specifically, platelets. The aim of this study was to globally assess coagulation processes in PAH, by using non-conventional hemostatic tests, along with markers of platelet activation and endothelial dysfunction. We studied 44 new PAH patients (22 with idiopathic PAH and 22 with connective tissue disease) and 25 healthy controls. The following tests were performed: platelet function analyzer-100 (PFA-100), light transmission aggregometry (LTA), rotational thromboelastometry (ROTEM), endogenous thrombin potential (ETP), serotonin, thromboxane A2 and p-selectin plasma levels, and von Willebrand antigen (VWF:Ag) and activity (VWF:Ac). Our results showed that PAH patients had diminished platelet aggregation, presence of disaggregation, defective initiation of the clotting process and clot propagation, and diminished thrombin formation capacity. Serotonin, thromboxane A2 and p-selectin levels were increased, and VWF:Ag and VWF:Ac decreased in the same population. The results of this study suggest that the platelets of PAH patients are activated and present functional abnormalities. The procoagulant activity, in general, appears to be impaired probably due to a sustained and prolonged activation of the procoagulant processes. Larger observational studies are warranted to confirm these laboratory findings.

Keywords: bloodcoagulation disorders; p-selectin; platelet aggregation; pulmonary arterial hypertension; serotonin; thrombin; thromboxane A2; von Willebrand

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