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Selvaraj J, Sardar H, Vishnupriya V, et al. Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant. Bioinformation. 2020;16(7):561-566doi: 10.6026/97320630016561.
Selvaraj, J., Sardar, H., Vishnupriya, V., Balakrishna, J. P., Mohan, S. K., Nivedha, R. P., Vijayalakshmi, P., & Ponnulakshmi, R. (2020). Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant. Bioinformation, 16(7), 561-566. https://doi.org/10.6026/97320630016561
Selvaraj, Jayaraman, et al. "Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant." Bioinformation vol. 16,7 (2020): 561-566. doi: https://doi.org/10.6026/97320630016561
Selvaraj J, Sardar H, Vishnupriya V, Balakrishna JP, Mohan SK, Nivedha RP, Vijayalakshmi P, Ponnulakshmi R. Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant. Bioinformation. 2020 Jul 31;16(7):561-566. doi: 10.6026/97320630016561. eCollection 2020. PMID: 32994682; PMCID: PMC7505243.
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Bioinformation. 2020 Jul 31;16(7):561-566. doi: 10.6026/97320630016561. eCollection 2020.

Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant.

Bioinformation

Jayaraman Selvaraj, Hussain Sardar, Veeraraghavan Vishnupriya, Janardhana Papayya Balakrishna, Surapaneni Krishna Mohan, Rajamanickam Pon Nivedha, Periyasamy Vijayalakshmi, Rajagopal Ponnulakshmi

Affiliations

  1. Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
  2. Department of Biotechnology, Government Science College, Chitradurga-577501, Karnataka, India.
  3. Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, India.
  4. Department of Biochemistry and Department of Clinical Skills and Simulation, Panimalar Medical College Hospital and Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India.
  5. Exonn Biosciences, Ticel Bio Park, Chennai-600 0113, India.
  6. PG and Research Department of Biotechnology and Bioinformatics, Holy Cross College (Autonomous), Trichy- 620002, Tamil Nadu, India.
  7. Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.

PMID: 32994682 PMCID: PMC7505243 DOI: 10.6026/97320630016561

Abstract

Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.

© 2020 Biomedical Informatics.

Keywords: Alzheimer's disease; Gymnema sylvestre; Molecular docking; Protein Network analysis

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