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Szczepek AJ, Dudnik T, Karayay B, et al. Mast Cells in the Auditory Periphery of Rodents. Brain Sci. 2020;10(10)doi: 10.3390/brainsci10100697.
Szczepek, A. J., Dudnik, T., Karayay, B., Sergeeva, V., Olze, H., & Smorodchenko, A. (2020). Mast Cells in the Auditory Periphery of Rodents. Brain sciences, 10(10), . https://doi.org/10.3390/brainsci10100697
Szczepek, Agnieszka J, et al. "Mast Cells in the Auditory Periphery of Rodents." Brain sciences vol. 10,10 (2020). doi: https://doi.org/10.3390/brainsci10100697
Szczepek AJ, Dudnik T, Karayay B, Sergeeva V, Olze H, Smorodchenko A. Mast Cells in the Auditory Periphery of Rodents. Brain Sci. 2020 Oct 01;10(10). doi: 10.3390/brainsci10100697. PMID: 33019672; PMCID: PMC7601519.
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Brain Sci. 2020 Oct 01;10(10). doi: 10.3390/brainsci10100697.

Mast Cells in the Auditory Periphery of Rodents.

Brain sciences

Agnieszka J Szczepek, Tatyana Dudnik, Betül Karayay, Valentina Sergeeva, Heidi Olze, Alina Smorodchenko

Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
  2. Department of Medical Biology with Course of Microbiology and Virology, Chuvash State University, 428034 Cheboksary, Russia.
  3. Department of Human Medicine, MSH Medical School Hamburg, University of Applied Sciences and Medical University, 20457 Hamburg, Germany.

PMID: 33019672 PMCID: PMC7601519 DOI: 10.3390/brainsci10100697

Abstract

Mast cells (MCs) are densely granulated cells of myeloid origin and are a part of immune and neuroimmune systems. MCs have been detected in the endolymphatic sac of the inner ear and are suggested to regulate allergic hydrops. However, their existence in the cochlea has never been documented. In this work, we show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis. The identity of MCs was confirmed in cochlear cryosections and flat preparations using avidin and antibodies against c-Kit/CD117, chymase, tryptase, and FcεRIα. The number of MCs decreased significantly during postnatal development, resulting in only a few MCs present in the flat preparation of the cochlea of a rat. In addition, exposure to 40 µM cisplatin for 24 h led to a significant reduction in cochlear MCs. The presence of MCs in the cochlea may shed new light on postnatal maturation of the auditory periphery and possible involvement in the ototoxicity of cisplatin. Presented data extend the current knowledge about the physiology and pathology of the auditory periphery. Future functional studies should expand and translate this new basic knowledge to clinics.

Keywords: auditory periphery; cochlea; mast cell

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