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Katsuda SI, Fujikura Y, Horikoshi Y, et al. Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits. J Atheroscler Thromb. 2020;28(6):611-621doi: 10.5551/jat.57364.
Katsuda, S. I., Fujikura, Y., Horikoshi, Y., Hazama, A., Shimizu, T., & Shirai, K. (2021). Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits. Journal of atherosclerosis and thrombosis, 28(6), 611-621. https://doi.org/10.5551/jat.57364
Katsuda, Shin-Ichiro, et al. "Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits." Journal of atherosclerosis and thrombosis vol. 28,6 (2021): 611-621. doi: https://doi.org/10.5551/jat.57364
Katsuda SI, Fujikura Y, Horikoshi Y, Hazama A, Shimizu T, Shirai K. Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits. J Atheroscler Thromb. 2021 Jun 01;28(6):611-621. doi: 10.5551/jat.57364. Epub 2020 Sep 11. PMID: 32921698; PMCID: PMC8219534.
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J Atheroscler Thromb. 2021 Jun 01;28(6):611-621. doi: 10.5551/jat.57364. Epub 2020 Sep 11.

Different Responses of Arterial Stiffness between the Aorta and the Iliofemoral Artery during the Administration of Phentolamine and Atenolol in Rabbits.

Journal of atherosclerosis and thrombosis

Shin-Ichiro Katsuda, Yuko Fujikura, Yuko Horikoshi, Akihiro Hazama, Tsuyoshi Shimizu, Kohji Shirai

Affiliations

  1. Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine.
  2. Yuri Kumiai General Hospital.
  3. Department of Clinical Laboratory Sciences,School of Health Sciences, Fukushima Medical University.
  4. Shimizu Institute of Space Physiology, Suwa Maternity Clinic.
  5. Seijinkai Mihama Hospital.

PMID: 32921698 PMCID: PMC8219534 DOI: 10.5551/jat.57364

Abstract

AIM: The mechanism underlying the stiffness of the aorta and iliofemoral artery that is required to maintain blood pressure (BP) is unclear. A new stiffness index of the aorta (aBeta) and iliac-femoral arteries (ifBeta) was defined by applying the cardio-ankle vascular index (CAVI). We compared changes in stiffness of the two arteries in response to reduced BP, due to the non-selective α adrenergic blocker phentolamine and the β

METHODS: Pressure waves at the origin (oA) and distal ends of the aorta (dA) and the distal end of the left femoral artery (fA) were recorded simultaneously using three pressure sensors in 25 anesthetized rabbits. Phentolamine (50 µg/kg/min) and atenolol (10 mg/kg/min) were infused for 2 min. The pulse wave velocity (PWV) in each artery was determined; aBeta, ifBeta, and whole Beta (aifBeta) were calculated by the following formula; Beta=2ρ/PP×ln(SBP/DBP)×PWV

RESULTS: SBP and DBP at oA, dA, and fA decreased by the administration of phentolamine and atenolol, with and without decreased total peripheral vascular resistance. After phentramine infusion, cardiac output (CO), aBeta, and aifBeta increased, while ifBeta decreased. After infusion of atenolol, CO decreased, while aBeta, ifBeta, and aifBeta remained unchanged.

CONCLUSION: The contradictory reactions of aBeta and ifBeta to phentolamine suggest that the stiffness of the aorta and ilio-femoral artery is regulated separately during decreased BP induced by phentolamine, but not by atenolol.

Keywords: Arterial stiffness; Atenolol; Beta; Blood pressure; Phentolamine

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