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Fan L, Namani R, Choy JS, et al. Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation. Front Physiol. 2020;11:915doi: 10.3389/fphys.2020.00915.
Fan, L., Namani, R., Choy, J. S., Kassab, G. S., & Lee, L. C. (2020). Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation. Frontiers in physiology, 11915. https://doi.org/10.3389/fphys.2020.00915
Fan, Lei, et al. "Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation." Frontiers in physiology vol. 11 (2020): 915. doi: https://doi.org/10.3389/fphys.2020.00915
Fan L, Namani R, Choy JS, Kassab GS, Lee LC. Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation. Front Physiol. 2020 Aug 14;11:915. doi: 10.3389/fphys.2020.00915. eCollection 2020. PMID: 32922304; PMCID: PMC7457036.
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Front Physiol. 2020 Aug 14;11:915. doi: 10.3389/fphys.2020.00915. eCollection 2020.

Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation.

Frontiers in physiology

Lei Fan, Ravi Namani, Jenny S Choy, Ghassan S Kassab, Lik Chuan Lee

Affiliations

  1. Department of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
  2. California Medical Innovation Institute, San Diego, CA, United States.

PMID: 32922304 PMCID: PMC7457036 DOI: 10.3389/fphys.2020.00915

Abstract

Mechanical dyssynchrony affects left ventricular (LV) mechanics and coronary perfusion. Due to the confounding effects of their bi-directional interactions, the mechanisms behind these changes are difficult to isolate from experimental and clinical studies alone. Here, we develop and calibrate a closed-loop computational model that couples the systemic circulation, LV mechanics, and coronary perfusion. The model is applied to simulate the impact of mechanical dyssynchrony on coronary flow in the left anterior descending artery (LAD) and left circumflex artery (LCX) territories caused by regional alterations in perfusion pressure and intramyocardial pressure (

Copyright © 2020 Fan, Namani, Choy, Kassab and Lee.

Keywords: bi-directional interactions; coronary perfusion; ischemia; mechanical dyssynchrony; systemic circulation

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