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Cheng L, Vella LJ, Barnham KJ, et al. Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles. J Extracell Vesicles. 2020;9(1):1766822doi: 10.1080/20013078.2020.1766822.
Cheng, L., Vella, L. J., Barnham, K. J., McLean, C., Masters, C. L., & Hill, A. F. (2020). Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles. Journal of extracellular vesicles, 9(1), 1766822. https://doi.org/10.1080/20013078.2020.1766822
Cheng, Lesley, et al. "Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles." Journal of extracellular vesicles vol. 9,1 (2020): 1766822. doi: https://doi.org/10.1080/20013078.2020.1766822
Cheng L, Vella LJ, Barnham KJ, McLean C, Masters CL, Hill AF. Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles. J Extracell Vesicles. 2020 Jun 04;9(1):1766822. doi: 10.1080/20013078.2020.1766822. PMID: 32922692; PMCID: PMC7448944.
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J Extracell Vesicles. 2020 Jun 04;9(1):1766822. doi: 10.1080/20013078.2020.1766822.

Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles.

Journal of extracellular vesicles

Lesley Cheng, Laura J Vella, Kevin J Barnham, Catriona McLean, Colin L Masters, Andrew F Hill

Affiliations

  1. The Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia.
  2. Florey Institute of Neuroscience, The University of Melbourne, Victoria, Australia.
  3. Victorian Brain Bank, Florey Institute of Neurosciences, Victoria, Australia.

PMID: 32922692 PMCID: PMC7448944 DOI: 10.1080/20013078.2020.1766822

Abstract

Alzheimer's disease is a progressive neurodegenerative disorder, with the strongest disease-associated changes observed at clinical or end-stage disease. Transcriptomic deregulation of miRNA expression can spread via "horizontal" RNA transfer through extracellular vesicles (EVs) to act in conjunction with proteins, leading to changes in mRNA, which can provide early signals to indicate forthcoming neuropathological changes in the brain. Here, we analysed the small RNA content, in particular, miRNA, contained in brain-derived EVs isolated from the frontal cortex of Alzheimer's subjects (

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

Keywords: Alzheimer’s disease; brain derived exosomes and extracellular vesicles; exosomes; miRNA

Conflict of interest statement

No potential conflict of interest was reported by the authors.

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