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Circulation. 2021 Feb 16;143(7):650-660. doi: 10.1161/CIRCULATIONAHA.120.047065. Epub 2020 Sep 21.

Trends in Recurrent Coronary Heart Disease After Myocardial Infarction Among US Women and Men Between 2008 and 2017.

Circulation

Sanne A E Peters, Lisandro D Colantonio, Yuling Dai, Hong Zhao, Vera Bittner, Michael E Farkouh, Paul Dluzniewski, Bharat Poudel, Paul Muntner, Mark Woodward

Affiliations

  1. The George Institute for Global Health, Imperial College London, UK (S.A.E.P., M.W.).
  2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, The Netherlands (S.A.E.P.).
  3. The George Institute for Global Health, University of New South Wales, Sydney, Australia (S.A.E.P., M.W.).
  4. Department of Epidemiology (L.D.C., Y.D., H.Z., B.P., P.M.), University of Alabama at Birmingham.
  5. Division of Cardiovascular Disease (V.B.), University of Alabama at Birmingham.
  6. Peter Munk Cardiac Centre and Heart and Stroke Richard Lewar Centre, University of Toronto, ON, Canada (M.E.F.).
  7. Center for Observational Research, Amgen Inc, Thousand Oaks, CA (P.D.).
  8. Department of Epidemiology, Johns Hopkins University, Baltimore, MD (M.W.).

PMID: 32951451 DOI: 10.1161/CIRCULATIONAHA.120.047065

Abstract

BACKGROUND: Rates for recurrent coronary heart disease (CHD) events have declined in the United States. However, few studies have assessed whether this decline has been similar among women and men.

METHODS: Data were used from 770 408 US women and 700 477 US men <65 years of age with commercial health insurance through MarketScan and ≥66 years of age with government health insurance through Medicare who had a myocardial infarction (MI) hospitalization between 2008 and 2017. Women and men were followed up for recurrent MI, recurrent CHD events (ie, recurrent MI or coronary revascularization), heart failure hospitalization, and all-cause mortality (Medicare only) in the 365 days after MI.

RESULTS: From 2008 to 2017, age-standardized recurrent MI rates per 1000 person-years decreased from 89.2 to 72.3 in women and from 94.2 to 81.3 in men (multivariable-adjusted

CONCLUSIONS: Rates of recurrent MI, recurrent CHD events, heart failure hospitalization, and mortality in the first year after an MI declined considerably between 2008 and 2017 in both men and women, with proportionally greater reductions for women than men. However, rates remain very high, and rates of recurrent MI, recurrent CHD events, and death continue to be higher among men than women.

Keywords: myocardial infarction; secondary prevention; sex characteristics; trends

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