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Pearson JT, Shirai M, Sukumaran V, et al. Ghrelin and vascular protection. Vasc Biol. 2019;1(1):H97-H102doi: 10.1530/VB-19-0024.
Pearson, J. T., Shirai, M., Sukumaran, V., Du, C. K., Tsuchimochi, H., Sonobe, T., Waddingham, M. T., Katare, R., & Schwenke, D. O. (2019). Ghrelin and vascular protection. Vascular biology (Bristol, England), 1(1), H97-H102. https://doi.org/10.1530/VB-19-0024
Pearson, James T, et al. "Ghrelin and vascular protection." Vascular biology (Bristol, England) vol. 1,1 (2019): H97-H102. doi: https://doi.org/10.1530/VB-19-0024
Pearson JT, Shirai M, Sukumaran V, Du CK, Tsuchimochi H, Sonobe T, Waddingham MT, Katare R, Schwenke DO. Ghrelin and vascular protection. Vasc Biol. 2019 Sep 05;1(1):H97-H102. doi: 10.1530/VB-19-0024. eCollection 2019. PMID: 32923960; PMCID: PMC7439925.
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Vasc Biol. 2019 Sep 05;1(1):H97-H102. doi: 10.1530/VB-19-0024. eCollection 2019.

Ghrelin and vascular protection.

Vascular biology (Bristol, England)

James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare, Daryl O Schwenke

Affiliations

  1. Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
  2. Department of Physiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  3. Department of Physiology, HeartOtago, School of Biomedical Sciences University of Otago, Dunedin, New Zealand.

PMID: 32923960 PMCID: PMC7439925 DOI: 10.1530/VB-19-0024

Abstract

Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.

© 2019 The authors.

Keywords: GHS-R1a; angiogenesis; ghrelin; inflammation; vasodilation

Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review.

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