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Khan IS, Dar KB, Ganie SA, et al. Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats. Drug Chem Toxicol. 2020;1-10doi: 10.1080/01480545.2020.1825472.
Khan, I. S., Dar, K. B., Ganie, S. A., & Ali, M. N. (2020). Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats. Drug and chemical toxicology, 1-10. https://doi.org/10.1080/01480545.2020.1825472
Khan, Ishfaq Shafi, et al. "Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats." Drug and chemical toxicology vol. (2020): 1-10. doi: https://doi.org/10.1080/01480545.2020.1825472
Khan IS, Dar KB, Ganie SA, Ali MN. Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats. Drug Chem Toxicol. 2020 Oct 01;1-10. doi: 10.1080/01480545.2020.1825472. Epub 2020 Oct 01. PMID: 33003957.
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Drug Chem Toxicol. 2020 Oct 01;1-10. doi: 10.1080/01480545.2020.1825472. Epub 2020 Oct 01.

Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats.

Drug and chemical toxicology

Ishfaq Shafi Khan, Khalid Bashir Dar, Showkat Ahmad Ganie, Md Niamat Ali

Affiliations

  1. Cytogenetics and Molecular Biology Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, India.
  2. Department of Clinical Biochemistry, University of Kashmir, Srinagar, India.

PMID: 33003957 DOI: 10.1080/01480545.2020.1825472

Abstract

Sodium benzoate is a widely used food and pharmaceutical preservative due to its antibacterial and antifungal activity. In the present study effect of different concentrations of sodium benzoate on hepatic antioxidants, inflammatory cytokines (TNF-α, IFN-γ, IL-1β and IL-6), biochemical markers and histopathology of liver was evaluated. Twenty five adult rats (aged 1-2 months) with 5 rats per group were randomly distributed into 5 groups. Group 1 rats were used as control and all groups (1-5) were provided with water and fed

Keywords: Inflammation; inflammatory cytokines; oxidative stress; sodium benzoate

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