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Bonacchi R, Rocca MA, Ramirez GA, et al. Resting state network functional connectivity abnormalities in systemic lupus erythematosus: correlations with neuropsychiatric impairment. Mol Psychiatry. 2020;26(7):3634-3645doi: 10.1038/s41380-020-00907-z.
Bonacchi, R., Rocca, M. A., Ramirez, G. A., Bozzolo, E. P., Canti, V., Preziosa, P., Valsasina, P., Riccitelli, G. C., Meani, A., Moiola, L., Rovere-Querini, P., Manfredi, A. A., & Filippi, M. (2021). Resting state network functional connectivity abnormalities in systemic lupus erythematosus: correlations with neuropsychiatric impairment. Molecular psychiatry, 26(7), 3634-3645. https://doi.org/10.1038/s41380-020-00907-z
Bonacchi, Raffaello, et al. "Resting state network functional connectivity abnormalities in systemic lupus erythematosus: correlations with neuropsychiatric impairment." Molecular psychiatry vol. 26,7 (2021): 3634-3645. doi: https://doi.org/10.1038/s41380-020-00907-z
Bonacchi R, Rocca MA, Ramirez GA, Bozzolo EP, Canti V, Preziosa P, Valsasina P, Riccitelli GC, Meani A, Moiola L, Rovere-Querini P, Manfredi AA, Filippi M. Resting state network functional connectivity abnormalities in systemic lupus erythematosus: correlations with neuropsychiatric impairment. Mol Psychiatry. 2021 Jul;26(7):3634-3645. doi: 10.1038/s41380-020-00907-z. Epub 2020 Oct 13. PMID: 33051605.
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Mol Psychiatry. 2021 Jul;26(7):3634-3645. doi: 10.1038/s41380-020-00907-z. Epub 2020 Oct 13.

Resting state network functional connectivity abnormalities in systemic lupus erythematosus: correlations with neuropsychiatric impairment.

Molecular psychiatry

Raffaello Bonacchi, Maria A Rocca, Giuseppe A Ramirez, Enrica P Bozzolo, Valentina Canti, Paolo Preziosa, Paola Valsasina, Gianna C Riccitelli, Alessandro Meani, Lucia Moiola, Patrizia Rovere-Querini, Angelo A Manfredi, Massimo Filippi

Affiliations

  1. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  2. Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  3. Vita-Salute San Raffaele University, Milan, Italy.
  4. Unit of Immunology, Rheumatology, Allergy and Rare Diseases & Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  5. Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  6. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. [email protected].
  7. Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. [email protected].
  8. Vita-Salute San Raffaele University, Milan, Italy. [email protected].
  9. Neurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. [email protected].

PMID: 33051605 DOI: 10.1038/s41380-020-00907-z

Abstract

Neuropsychiatric manifestations are highly prevalent in systemic lupus erythematosus (SLE)-patients. We aimed to unravel the substrates of these manifestations by investigating abnormalities of resting state (RS) functional connectivity (FC) and their correlations with neuropsychiatric variables in SLE-patients. Thirty-two SLE-patients and 32 age- and sex-matched healthy controls (HC) underwent brain 3T RS fMRI. Neuropsychological assessment was performed for all SLE-patients. The main large-scale cognitive and psychiatric functional networks were derived and between-group comparisons and correlations with neuropsychological measures were performed. Compared to HC, SLE-patients exhibited increased RS FC in the right middle cingulate cortex and decreased RS FC in the left precuneus within default-mode network (DMN). They also showed increased RS FC in the left cerebellar crus I and left posterior cingulate cortex, and decreased RS FC in the left angular gyrus within working-memory networks (WMN). Compared to HC, SLE-patients exhibited increased RS FC in the left insular cortex and decreased RS FC in the right anterior cingulate cortex within salience network (SN), as well as decreased RS FC in the right middle frontal gyrus within executive-control network (ECN). Correlation analysis indicated a maladaptive role for left angular gyrus and cerebellar RS FC abnormalities in WMN, affecting memory and executive functions; and for precuneus and insular abnormalities in DMN and SN for psychiatric symptoms. Cingulate cortex modifications within DMN and SN correlated with better memory and global cognitive performance. Significant RS FC alterations in relevant cognitive and psychiatric networks occur in SLE-patients and participate in the pathophysiology of neuropsychiatric symptoms.

© 2020. The Author(s), under exclusive licence to Springer Nature Limited.

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