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Hidalgo-Santos AD, Gastón-Téllez R, Ferrer-Lorente B, et al. Alteraciones inmunológicas asociadas a parotiditis crónica recurrente juvenil. [Immune disorders associated with juvenile recurrent chronic parotitis]. An Pediatr (Engl Ed). 2020;doi: 10.1016/j.anpedi.2020.08.007.
Hidalgo-Santos, A. D., Gastón-Téllez, R., Ferrer-Lorente, B., Pina-Pérez, R., & Oltra-Benavent, M. (2020). Alteraciones inmunológicas asociadas a parotiditis crónica recurrente juvenil. [Immune disorders associated with juvenile recurrent chronic parotitis]. Anales de pediatria, . https://doi.org/10.1016/j.anpedi.2020.08.007
Hidalgo-Santos, Antonio David, et al. "Alteraciones inmunológicas asociadas a parotiditis crónica recurrente juvenil." [Immune disorders associated with juvenile recurrent chronic parotitis]. Anales de pediatria vol. (2020). doi: https://doi.org/10.1016/j.anpedi.2020.08.007
Hidalgo-Santos AD, Gastón-Téllez R, Ferrer-Lorente B, Pina-Pérez R, Oltra-Benavent M. Alteraciones inmunológicas asociadas a parotiditis crónica recurrente juvenil. [Immune disorders associated with juvenile recurrent chronic parotitis]. An Pediatr (Engl Ed). 2020 Sep 29; doi: 10.1016/j.anpedi.2020.08.007. Epub 2020 Sep 29. Spanish. PMID: 33008791.
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An Pediatr (Engl Ed). 2020 Sep 29; doi: 10.1016/j.anpedi.2020.08.007. Epub 2020 Sep 29.

[Immune disorders associated with juvenile recurrent chronic parotitis].

Anales de pediatria

[Article in Spanish]
Antonio David Hidalgo-Santos, Rubén Gastón-Téllez, Begoña Ferrer-Lorente, Raquel Pina-Pérez, Manuel Oltra-Benavent

Affiliations

  1. Servicio de Pediatría, Hospital Universitari i Politècnic La Fe, Valencia, España.
  2. Servicio de Pediatría, Hospital Universitari i Politècnic La Fe, Valencia, España. Electronic address: [email protected].

PMID: 33008791 DOI: 10.1016/j.anpedi.2020.08.007

Abstract

INTRODUCTION: Juvenile recurrent chronic parotitis is a rare disease of unknown cause. There is a growing interest in its autoimmune aetiology and its relationship with dysfunctions of cellular and humoral immunity, although there is no agreed protocol for complementary investigations for its study. A consecutive series of cases is presented where the immune alterations and associated autoimmune disorders are investigated, proposing a study algorithm.

PATIENTS AND METHODS: A retrospective study was carried out on patients who had juvenile recurrent chronic parotitis during the period from 2013 to 2016 and a follow-up of at least 2 years. After its clinical and ultrasound diagnosis, complementary examinations were systematically carried out to investigate infectious, immune, and autoimmune diseases.

RESULTS: Of a total of 36 patients with inclusion criteria, 16 (44%) were found with some analytical alteration of a non-specific immunological nature (positive ANA, high IgG, low complement factor 4), or associated with a specific diagnosis, as occurred in 11 patients: Selective IgA deficiency (2), Sjögren's syndrome associated or not with systemic lupus erythematosus (3), coeliac disease associated or not with diabetes mellitus (4), Hashimoto's thyroiditis (1), and acquired immunodeficiency syndrome (1).

CONCLUSION: Juvenile recurrent chronic parotitis can be considered a sentinel sign of other diseases of immunological/autoimmune aetiology for which the diagnosis, monitoring and early treatment can improve its prognosis. Viral infectious aetiology, with the exception of HIV, is not a priority in the study of recurrences.

Copyright © 2020. Publicado por Elsevier España, S.L.U.

Keywords: Celiac disease; Celiaquía; Déficit de IgA; Enfermedad inmunológica; IgA deficiency; Immunological diseases; Parotiditis recurrente juvenil; Parotitis Juvenile recurrent; Sjögren's syndrome; Síndrome de Sjögren.

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