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Lima TFN, Frech FS, Blachman-Braun R, et al. Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone. Int J Impot Res. 2020;doi: 10.1038/s41443-020-00358-8.
Lima, T. F. N., Frech, F. S., Blachman-Braun, R., Rakitina, E., Patel, P., & Ramasamy, R. (2020). Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone. International journal of impotence research, . https://doi.org/10.1038/s41443-020-00358-8
Lima, Thiago Fernandes Negris, et al. "Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone." International journal of impotence research vol. (2020). doi: https://doi.org/10.1038/s41443-020-00358-8
Lima TFN, Frech FS, Blachman-Braun R, Rakitina E, Patel P, Ramasamy R. Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone. Int J Impot Res. 2020 Oct 02; doi: 10.1038/s41443-020-00358-8. Epub 2020 Oct 02. PMID: 33009497.
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Int J Impot Res. 2020 Oct 02; doi: 10.1038/s41443-020-00358-8. Epub 2020 Oct 02.

Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone.

International journal of impotence research

Thiago Fernandes Negris Lima, Fabio Stefano Frech, Ruben Blachman-Braun, Evgeniya Rakitina, Premal Patel, Ranjith Ramasamy

Affiliations

  1. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States. [email protected].
  2. Department of Urology, University of Miami Miller School of Medicine, Miami, FL, United States.
  3. Department of Urology, University of Manitoba, Winnipeg, MB, Canada.

PMID: 33009497 DOI: 10.1038/s41443-020-00358-8

Abstract

Obesity's negative association with serum testosterone can be explained by either decreasing luteinizing hormone (LH) production from the pituitary gland and/or directly impacting intratesticular testosterone production. We hypothesize that obesity will negatively impact intratesticular testosterone levels when compared to those of non-obese men. We performed a cross-sectional analysis of men with symptoms of testosterone deficiency and male infertility between July 2018 and April 2020 to evaluate the association between body mass index (BMI) and age with intratesticular testosterone (using serum 17-hydroxyprogesterone (17-OHP) as a biomarker), and between BMI with LH. Univariable and multiple linear regression analysis were performed using confounding variables to predict 17-OHP and testosterone. A total of 340 men were selected. Median age was 38 [33-44] years, BMI 27.8 [25.4-31.1] kg/m

© 2020. The Author(s), under exclusive licence to Springer Nature Limited.

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